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Decoding efficacy and resistance space at a drug binding site.

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Title: Decoding efficacy and resistance space at a drug binding site.
Authors: Altmann S; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK., Mendoza-Martinez C; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK., Ridgway M; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK., Tinti M; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK., Saini JS; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK., Ibrahim PEGF; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK., Thomas M; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK., De Rycker M; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK., Bodkin MJ; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK., Horn D; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK. d.horn@dundee.ac.uk.
Source: Nature communications [Nat Commun] 2026 Feb 04; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Altmann+S%22">Altmann S</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Mendoza-Martinez+C%22">Mendoza-Martinez C</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Ridgway+M%22">Ridgway M</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Tinti+M%22">Tinti M</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Saini+JS%22">Saini JS</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Ibrahim+PEGF%22">Ibrahim PEGF</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Thomas+M%22">Thomas M</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22De+Rycker+M%22">De Rycker M</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Bodkin+MJ%22">Bodkin MJ</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK.; Drug Discovery Unit, Faculty of Life Sciences, University of Dundee, Dundee, UK.<br /><searchLink fieldCode="AU" term="%22Horn+D%22">Horn D</searchLink>; Wellcome Centre for Anti-Infectives Research, Faculty of Life Sciences, University of Dundee, Dundee, UK. d.horn@dundee.ac.uk.
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              Text: 2026 Feb 04
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