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Pilot phase clinical trial of a wearable, electrochemical aptamer-based patch for continuous drug concentration measurement.

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Title: Pilot phase clinical trial of a wearable, electrochemical aptamer-based patch for continuous drug concentration measurement.
Authors: Booth MA; Nutromics Pty Ltd., Brunswick, Victoria, Australia.; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia., Erdal MK; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Larson M; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Birthisel E; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Friedel M; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Gonçales VR; Nutromics Pty Ltd., Brunswick, Victoria, Australia.; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia., Alinezhad A; Nutromics Pty Ltd., Brunswick, Victoria, Australia.; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia., Morawski F; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Li J; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Hogan N; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Teo S; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Wordsworth J; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Khanna S; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Van Eps J; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Boyd S; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Dewhirst L; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Gerson J; Nutromics Pty Ltd., Brunswick, Victoria, Australia., D'Souza D; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Yin W; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Padmanabhan PT; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Batchelor RH; Nutromics Pty Ltd., Brunswick, Victoria, Australia.; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia., Farnkopf A; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Hodges A; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Chambers G; Nutromics Pty Ltd., Brunswick, Victoria, Australia., Braude M; Department of Gastroenterology and Hepatology, Monash Health, Melbourne, Victoria, Australia.; School of Clinical Sciences, Monash University, Clayton, Victoria, Australia., Kippin TE; Department of Psychology and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA., Kirkpatrick CMJ; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia., Justin Gooding J; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia., Pianko S; Department of Gastroenterology and Hepatology, Monash Health, Melbourne, Victoria, Australia.; School of Clinical Sciences, Monash University, Clayton, Victoria, Australia., Stocker SL; Sydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. sophie.stocker@sydney.edu.au.; Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital, Sydney, New South Wales, Australia. sophie.stocker@sydney.edu.au.; St. Vincent's Clinical Campus, UNSW Medicine, Sydney, New South Wales, Australia. sophie.stocker@sydney.edu.au.; Sydney Institute for Infectious Diseases, University of Sydney, Sydney, New South Wales, Australia. sophie.stocker@sydney.edu.au., Plaxco KW; Departments of BioEngineering and of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA. kwp@ucsb.edu.
Source: Nature biotechnology [Nat Biotechnol] 2026 Feb 04. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Booth+MA%22">Booth MA</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Erdal+MK%22">Erdal MK</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Larson+M%22">Larson M</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Birthisel+E%22">Birthisel E</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Friedel+M%22">Friedel M</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gonçales+VR%22">Gonçales VR</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Alinezhad+A%22">Alinezhad A</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Morawski+F%22">Morawski F</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hogan+N%22">Hogan N</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Teo+S%22">Teo S</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Wordsworth+J%22">Wordsworth J</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Khanna+S%22">Khanna S</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Van+Eps+J%22">Van Eps J</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Boyd+S%22">Boyd S</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Dewhirst+L%22">Dewhirst L</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Gerson+J%22">Gerson J</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22D'Souza+D%22">D'Souza D</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Yin+W%22">Yin W</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Padmanabhan+PT%22">Padmanabhan PT</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Batchelor+RH%22">Batchelor RH</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Farnkopf+A%22">Farnkopf A</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Hodges+A%22">Hodges A</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Chambers+G%22">Chambers G</searchLink>; Nutromics Pty Ltd., Brunswick, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Braude+M%22">Braude M</searchLink>; Department of Gastroenterology and Hepatology, Monash Health, Melbourne, Victoria, Australia.; School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Kippin+TE%22">Kippin TE</searchLink>; Department of Psychology and Brain Sciences, University of California, Santa Barbara, Santa Barbara, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kirkpatrick+CMJ%22">Kirkpatrick CMJ</searchLink>; Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Justin+Gooding+J%22">Justin Gooding J</searchLink>; School of Chemistry, University of New South Wales, Sydney, New South Wales, Australia.<br /><searchLink fieldCode="AU" term="%22Pianko+S%22">Pianko S</searchLink>; Department of Gastroenterology and Hepatology, Monash Health, Melbourne, Victoria, Australia.; School of Clinical Sciences, Monash University, Clayton, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Stocker+SL%22">Stocker SL</searchLink>; Sydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. sophie.stocker@sydney.edu.au.; Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital, Sydney, New South Wales, Australia. sophie.stocker@sydney.edu.au.; St. Vincent's Clinical Campus, UNSW Medicine, Sydney, New South Wales, Australia. sophie.stocker@sydney.edu.au.; Sydney Institute for Infectious Diseases, University of Sydney, Sydney, New South Wales, Australia. sophie.stocker@sydney.edu.au.<br /><searchLink fieldCode="AU" term="%22Plaxco+KW%22">Plaxco KW</searchLink>; Departments of BioEngineering and of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA, USA. kwp@ucsb.edu.
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