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Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes.

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Title: Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes.
Authors: Zou XZ; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. zoe.zou@astrazeneca.com., Hu F; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Lou H; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Shanghai, China., Burren OS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Li X; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Megy K; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wheeler E; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wu Q; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.; Department of Mathematics, University of Tennessee, Knoxville, TN, USA., Atanur SS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Karpinski M; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Loesch D; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Fairhurst-Hunter Z; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Deevi SVV; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Oerton E; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wen S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Jiang X; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Salvoro C; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Mitchell J; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Nag A; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hollis B; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., O'Neill A; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Harrow J; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., MacArthur S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wasilewski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., O'Dell S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Tian L; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Shanghai, China., Smith KR; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Del Angel G; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA., Fabre M; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Dhindsa RS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA., Wang Q; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. slav.petrovski@astrazeneca.com.; Department of Medicine, University of Melbourne, Austin Health, Melbourne, Victoria, Australia. slav.petrovski@astrazeneca.com., Carss K; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
Corporate Authors: AstraZeneca Genomics Initiative
Source: Nature [Nature] 2026 Apr; Vol. 652 (8110), pp. 675-685. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article; Research Support, N.I.H., Extramural
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phenome-wide analysis of copy number variants in 470,727 UK Biobank genomes.
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  Data: <searchLink fieldCode="AU" term="%22Zou+XZ%22">Zou XZ</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. zoe.zou@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Hu+F%22">Hu F</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Lou+H%22">Lou H</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Burren+OS%22">Burren OS</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA.<br /><searchLink fieldCode="AU" term="%22Megy+K%22">Megy K</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wheeler+E%22">Wheeler E</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Wu+Q%22">Wu Q</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.; Department of Mathematics, University of Tennessee, Knoxville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Atanur+SS%22">Atanur SS</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Karpinski+M%22">Karpinski M</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Loesch+D%22">Loesch D</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fairhurst-Hunter+Z%22">Fairhurst-Hunter Z</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Deevi+SVV%22">Deevi SVV</searchLink>; 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Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tian+L%22">Tian L</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Smith+KR%22">Smith KR</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Del+Angel+G%22">Del Angel G</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Fabre+M%22">Fabre M</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK.; Department of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dhindsa+RS%22">Dhindsa RS</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.<br /><searchLink fieldCode="AU" term="%22Wang+Q%22">Wang Q</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.<br /><searchLink fieldCode="AU" term="%22Petrovski+S%22">Petrovski S</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. slav.petrovski@astrazeneca.com.; Department of Medicine, University of Melbourne, Austin Health, Melbourne, Victoria, Australia. slav.petrovski@astrazeneca.com.<br /><searchLink fieldCode="AU" term="%22Carss+K%22">Carss K</searchLink>; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2026 Apr; Vol. 652 (8110), pp. 675-685. <i>Date of Electronic Publication: </i>2026 Feb 04.
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