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Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.

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Title: Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
Authors: Sun Y; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China., Wei T; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China., Xu H; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China., Li H; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China., Zhou C; School of Medicine, Tongji University, Shanghai 200092, China., Liu X; School of Nursing and Health Sciences, Hong Kong Metropolitan University, Hong Kong SAR, China., Li Y; Department of Cardiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215000, China., Huang S; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China., Zhang Q; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China., Duan X; Nursing Department, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Source: Acta biochimica et biophysica Sinica [Acta Biochim Biophys Sin (Shanghai)] 2026 Feb 05; Vol. 58 (2), pp. 421-436.
Publication Type: Journal Article
Journal Info: Publisher: China Science Publishing & Media Ltd Country of Publication: China NLM ID: 101206716 Publication Model: Print Cited Medium: Internet ISSN: 1745-7270 (Electronic) Linking ISSN: 16729145 NLM ISO Abbreviation: Acta Biochim Biophys Sin (Shanghai) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
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  Data: <searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.<br /><searchLink fieldCode="AU" term="%22Wei+T%22">Wei T</searchLink>; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.<br /><searchLink fieldCode="AU" term="%22Li+H%22">Li H</searchLink>; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.<br /><searchLink fieldCode="AU" term="%22Zhou+C%22">Zhou C</searchLink>; School of Medicine, Tongji University, Shanghai 200092, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; School of Nursing and Health Sciences, Hong Kong Metropolitan University, Hong Kong SAR, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Cardiology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215000, China.<br /><searchLink fieldCode="AU" term="%22Huang+S%22">Huang S</searchLink>; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China.<br /><searchLink fieldCode="AU" term="%22Duan+X%22">Duan X</searchLink>; Nursing Department, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22China+Science+Publishing+%26+Media+Ltd%22">China Science Publishing & Media Ltd </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101206716 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1745-7270 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216729145%22">16729145 </searchLink><i>NLM ISO Abbreviation: </i>Acta Biochim Biophys Sin (Shanghai) <i>Subsets: </i>MEDLINE
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        Value: 10.3724/abbs.2026018
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              Text: 2026 Feb 05
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