Intensity-modulated proton therapy for patients with unresectable giant (≥ 10 cm) hepatocellular carcinoma: a retrospective analysis from two high-volume centers.

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Title: Intensity-modulated proton therapy for patients with unresectable giant (≥ 10 cm) hepatocellular carcinoma: a retrospective analysis from two high-volume centers.
Authors: Cheng JY; Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, No. 5, Fuxing St., Guishan Dist., Taoyuan City, 33305, Taiwan, ROC.; Center for General Education, Cheng Shiu University, Kaohsiung, Taiwan, ROC., Wang YM; Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, No. 5, Fuxing St., Guishan Dist., Taoyuan City, 33305, Taiwan, ROC.; School of Traditional Chinese, Chang Gung University, Taoyuan, Taiwan, ROC.; Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC., Chen YH; Division of Hematology-Oncology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC.; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC., Liu CM; Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, No. 5, Fuxing St., Guishan Dist., Taoyuan City, 33305, Taiwan, ROC., Huang EY; Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, No. 5, Fuxing St., Guishan Dist., Taoyuan City, 33305, Taiwan, ROC.; School of Traditional Chinese, Chang Gung University, Taoyuan, Taiwan, ROC.; Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, School of Medicine, College of Medicine, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC., Ou HY; Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC., Hu TH; Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC., Lu SN; Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC., Wang CC; Division of General Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC., Tseng JH; Department of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital and University, Taoyuan City, Taiwan, ROC., Lin SM; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital and University, Taoyuan City, Taiwan, ROC., Lin CC; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.; Department of Gastroenterology and Hepatology, New Taipei Municipal Tucheng Hospital (Built and Operated By Chang Gung Memorial Hospital), New Taipei, Taiwan, ROC., Chan KM; Department of General Surgery, Linkou Chang Gung Memorial Hospital and University, Taoyuan City, Taiwan, ROC., Chen WY; Department of Radiation Oncology, National Taiwan University Cancer Center, Taipei, Taiwan, ROC.; Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.; Devision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan., Huang BS; Department of Radiation Oncology & Proton and Radiation Therapy Center, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, No. 5, Fuxing St., Guishan Dist., Taoyuan City, 33305, Taiwan, ROC. beanson@cgmh.org.tw.; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC. beanson@cgmh.org.tw.; Department of Radiation Oncology, Linkou Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan, ROC. beanson@cgmh.org.tw.
Source: Japanese journal of radiology [Jpn J Radiol] 2026 Jun; Vol. 44 (6), pp. 1085-1094. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Springer Country of Publication: Japan NLM ID: 101490689 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1867-108X (Electronic) Linking ISSN: 18671071 NLM ISO Abbreviation: Jpn J Radiol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1867-108X
DOI:10.1007/s11604-026-01947-1