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APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease.

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Title: APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease.
Authors: Li F; Institute For Informatics (I2), Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA., Chen Y; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA., Western D; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA., Ali M; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA., Liu M; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA., Gong K; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA., Xu Y; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA., Lowery J; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA., Holtzman DM; Department of Neurology, Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, ., St. Louis, Missouri, USA., Robins C; Human Genetics & Genomics, Research Technologies, GSK, Cambridge, MA, USA., Eicher JD; Human Genetics & Genomics, Research Technologies, GSK, Cambridge, MA, USA., Huang YN; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Liu S; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Park T; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Saykin AJ; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Nho K; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA., Moqri M; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA., Mohs RC; Global Alzheimer's Platform Foundation, Washington, DC, USA., Farinas A; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Moran-Losada P; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA., Oh HS; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Icahn School of Medicine at Mount Sinai, New York, New York, USA., Wyss-Coray T; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA., Cruchaga C; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Source: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2026 Apr; Vol. 13 (21), pp. e13872. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: WILEY-VCH Country of Publication: Germany NLM ID: 101664569 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2198-3844 (Electronic) Linking ISSN: 21983844 NLM ISO Abbreviation: Adv Sci (Weinh) Subsets: MEDLINE
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  Data: APOE-stratified Proteomic and Metabolomic Analysis Reveals Mitochondrial Dysfunction Inflammation and Lipid Dysregulation in Alzheimer's Disease.
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  Data: <searchLink fieldCode="AU" term="%22Li+F%22">Li F</searchLink>; Institute For Informatics (I2), Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Western+D%22">Western D</searchLink>; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Ali+M%22">Ali M</searchLink>; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; 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Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Holtzman+DM%22">Holtzman DM</searchLink>; Department of Neurology, Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, ., St. Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Robins+C%22">Robins C</searchLink>; Human Genetics & Genomics, Research Technologies, GSK, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Eicher+JD%22">Eicher JD</searchLink>; Human Genetics & Genomics, Research Technologies, GSK, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Huang+YN%22">Huang YN</searchLink>; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Park+T%22">Park T</searchLink>; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Saykin+AJ%22">Saykin AJ</searchLink>; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Nho+K%22">Nho K</searchLink>; Center For Neuroimaging, Indiana Alzheimer's Disease Research Center, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.<br /><searchLink fieldCode="AU" term="%22Moqri+M%22">Moqri M</searchLink>; Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Mohs+RC%22">Mohs RC</searchLink>; Global Alzheimer's Platform Foundation, Washington, DC, USA.<br /><searchLink fieldCode="AU" term="%22Farinas+A%22">Farinas A</searchLink>; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Moran-Losada+P%22">Moran-Losada P</searchLink>; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Oh+HS%22">Oh HS</searchLink>; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Icahn School of Medicine at Mount Sinai, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Wyss-Coray+T%22">Wyss-Coray T</searchLink>; The Phil and Penny Knight Initiative for Brain Resilience, Stanford University, Stanford, California, USA.; Wu Tsai Neurosciences Institute, Stanford University, Stanford, California, USA.; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Cruchaga+C%22">Cruchaga C</searchLink>; Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
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