Multi-omics study identifies diagnostic metabolic signatures of early Parkinson's disease associated with dysregulated glutathione and TCA cycle metabolism.
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| Title: | Multi-omics study identifies diagnostic metabolic signatures of early Parkinson's disease associated with dysregulated glutathione and TCA cycle metabolism. |
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| Authors: | Wang N; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China., Li X; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China; Department of Neurology, The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan, Shandong, 250014, China., Li B; Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies Company Limited, Changzhou, Jiangsu Province, 213022, China., Li XY; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China., Lai H; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China., Zhu J; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China., Yao T; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China., Zhu Q; Department of Nephrology, The Third People's Hospital of Jingdezhen, Jiangxi Province, 333000, China., Shui G; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China; Guangzhou National Laboratory, Guangzhou, Guangdong, 510005, China. Electronic address: ghshui@genetics.ac.cn., Lam SM; Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies Company Limited, Changzhou, Jiangsu Province, 213022, China; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address: smlam@lipidall.com., Wang C; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China. Electronic address: cdongwang01@126.com. |
| Source: | Parkinsonism & related disorders [Parkinsonism Relat Disord] 2026 Mar; Vol. 144, pp. 108230. Date of Electronic Publication: 2026 Jan 31. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41643583 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Multi-omics study identifies diagnostic metabolic signatures of early Parkinson's disease associated with dysregulated glutathione and TCA cycle metabolism. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Wang+N%22">Wang N</searchLink>; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China; Department of Neurology, The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan, Shandong, 250014, China.<br /><searchLink fieldCode="AU" term="%22Li+B%22">Li B</searchLink>; Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies Company Limited, Changzhou, Jiangsu Province, 213022, China.<br /><searchLink fieldCode="AU" term="%22Li+XY%22">Li XY</searchLink>; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Lai+H%22">Lai H</searchLink>; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Yao+T%22">Yao T</searchLink>; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China.<br /><searchLink fieldCode="AU" term="%22Zhu+Q%22">Zhu Q</searchLink>; Department of Nephrology, The Third People's Hospital of Jingdezhen, Jiangxi Province, 333000, China.<br /><searchLink fieldCode="AU" term="%22Shui+G%22">Shui G</searchLink>; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China; Guangzhou National Laboratory, Guangzhou, Guangdong, 510005, China. Electronic address: ghshui@genetics.ac.cn.<br /><searchLink fieldCode="AU" term="%22Lam+SM%22">Lam SM</searchLink>; Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies Company Limited, Changzhou, Jiangsu Province, 213022, China; State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address: smlam@lipidall.com.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No.8 Gongti South Road, Chaoyang District, Beijing, 100020, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Disorders, Beijing, 100053, China. Electronic address: cdongwang01@126.com. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229513583%22">Parkinsonism & related disorders</searchLink> [Parkinsonism Relat Disord] 2026 Mar; Vol. 144, pp. 108230. <i>Date of Electronic Publication: </i>2026 Jan 31. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science%22">Elsevier Science </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9513583 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1873-5126 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213538020%22">13538020 </searchLink><i>NLM ISO Abbreviation: </i>Parkinsonism Relat Disord <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41643583 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.parkreldis.2026.108230 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 108230 Titles: – TitleFull: Multi-omics study identifies diagnostic metabolic signatures of early Parkinson's disease associated with dysregulated glutathione and TCA cycle metabolism. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Wang N – PersonEntity: Name: NameFull: Li X – PersonEntity: Name: NameFull: Li B – PersonEntity: Name: NameFull: Li XY – PersonEntity: Name: NameFull: Lai H – PersonEntity: Name: NameFull: Zhu J – PersonEntity: Name: NameFull: Yao T – PersonEntity: Name: NameFull: Zhu Q – PersonEntity: Name: NameFull: Shui G – PersonEntity: Name: NameFull: Lam SM – PersonEntity: Name: NameFull: Wang C IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2026 Mar Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1873-5126 Numbering: – Type: volume Value: 144 Titles: – TitleFull: Parkinsonism & related disorders Type: main |
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