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Reactive oxygen species-responsive Pluronic F127 hyaluronic hydrogel for targeted doxorubicin delivery in glioblastoma and enhanced survival with radiotherapy.

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Title: Reactive oxygen species-responsive Pluronic F127 hyaluronic hydrogel for targeted doxorubicin delivery in glioblastoma and enhanced survival with radiotherapy.
Authors: Wu TY; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan., Bui YP; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu, 300, Taiwan., Chen CH; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan., Huang CC; Taiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu, 302, Taiwan., Chen PY; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan., Liu YW; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 110, Taiwan., Darge HF; Center for Ocular Research & Education (CORE), School of Optometry and Vision Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada., Jeng US; National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu, 300, Taiwan; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan; College of Semiconductor Research, National Tsing Hua University, Hsinchu, 300, Taiwan., Lu LS; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, 110, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 110, Taiwan; TMU Precision Health Research Center, Taipei Medical University, Taipei, 110, Taiwan., Wang JS; Taiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu, 302, Taiwan., Harn HJ; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan; Department of Pathology, Hualien Tzu Chi Hospital, Tzu Chi University, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan., Lin SZ; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan., Lai JY; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; Advanced Membrane Materials Center, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; R&D Center for Membrane Technology, Chung Yuan Christian University, Taoyuan, 320, Taiwan; Department of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan, 320, Taiwan., Chen YS; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan; Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan; Center for General Education, Tzu Chi University, Hualien, 970, Taiwan. Electronic address: yschen0130@tzuchi.com.tw., Tsai HC; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; Advanced Membrane Materials Center, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; R&D Center for Membrane Technology, Chung Yuan Christian University, Taoyuan, 320, Taiwan. Electronic address: h.c.tsai@mail.ntust.edu.tw.
Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Feb; Vol. 347, pp. 150701. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Reactive oxygen species-responsive Pluronic F127 hyaluronic hydrogel for targeted doxorubicin delivery in glioblastoma and enhanced survival with radiotherapy.
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  Data: <searchLink fieldCode="AU" term="%22Wu+TY%22">Wu TY</searchLink>; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan.<br /><searchLink fieldCode="AU" term="%22Bui+YP%22">Bui YP</searchLink>; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu, 300, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan.<br /><searchLink fieldCode="AU" term="%22Huang+CC%22">Huang CC</searchLink>; Taiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu, 302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+PY%22">Chen PY</searchLink>; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+YW%22">Liu YW</searchLink>; Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Darge+HF%22">Darge HF</searchLink>; Center for Ocular Research & Education (CORE), School of Optometry and Vision Science, University of Waterloo, 200 University Avenue West, Waterloo, ON, N2L 3G1, Canada.<br /><searchLink fieldCode="AU" term="%22Jeng+US%22">Jeng US</searchLink>; National Synchrotron Radiation Research Center, Hsinchu Science Park, Hsinchu, 300, Taiwan; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 300, Taiwan; College of Semiconductor Research, National Tsing Hua University, Hsinchu, 300, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lu+LS%22">Lu LS</searchLink>; Department of Radiation Oncology, Taipei Medical University Hospital, Taipei, 110, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei, 110, Taiwan; TMU Precision Health Research Center, Taipei Medical University, Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+JS%22">Wang JS</searchLink>; Taiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu, 302, Taiwan.<br /><searchLink fieldCode="AU" term="%22Harn+HJ%22">Harn HJ</searchLink>; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan; Department of Pathology, Hualien Tzu Chi Hospital, Tzu Chi University, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+SZ%22">Lin SZ</searchLink>; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan; Department of Neurosurgery, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+JY%22">Lai JY</searchLink>; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; Advanced Membrane Materials Center, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; R&D Center for Membrane Technology, Chung Yuan Christian University, Taoyuan, 320, Taiwan; Department of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan, 320, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YS%22">Chen YS</searchLink>; Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan; Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan; Center for General Education, Tzu Chi University, Hualien, 970, Taiwan. Electronic address: yschen0130@tzuchi.com.tw.<br /><searchLink fieldCode="AU" term="%22Tsai+HC%22">Tsai HC</searchLink>; Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; Advanced Membrane Materials Center, National Taiwan University of Science and Technology, Taipei, 106, Taiwan; R&D Center for Membrane Technology, Chung Yuan Christian University, Taoyuan, 320, Taiwan. Electronic address: h.c.tsai@mail.ntust.edu.tw.
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      – Type: doi
        Value: 10.1016/j.ijbiomac.2026.150701
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      – Code: eng
        Text: English
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        StartPage: 150701
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      – TitleFull: Reactive oxygen species-responsive Pluronic F127 hyaluronic hydrogel for targeted doxorubicin delivery in glioblastoma and enhanced survival with radiotherapy.
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              Text: 2026 Feb
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