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Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.

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Title: Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.
Authors: Foster KA; Research Department of Haematology, University College London Cancer Institute, London, UK., Rees E; Research Department of Haematology, University College London Cancer Institute, London, UK., Ainley L; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK., Laidler A; Research Department of Haematology, University College London Cancer Institute, London, UK., Boyle EM; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK., Lee L; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK., Ward G; Research Department of Haematology, University College London Cancer Institute, London, UK., Galas-Filipowicz D; Research Department of Haematology, University College London Cancer Institute, London, UK., Fitzsimons E; Research Department of Haematology, University College London Cancer Institute, London, UK., Mikolajczak A; Research Department of Haematology, University College London Cancer Institute, London, UK., Lyon EJ; Research Department of Haematology, University College London Cancer Institute, London, UK., Jankovic D; Research Department of Haematology, University College London Cancer Institute, London, UK., Rahman J; Research Department of Haematology, University College London Cancer Institute, London, UK., Turakhia M; Research Department of Haematology, University College London Cancer Institute, London, UK., Mehta D; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK., Garrod-Ketchley C; Research Department of Haematology, University College London Cancer Institute, London, UK., Uddin I; CRUK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK.; Genomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK., Beattie G; CRUK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK.; Genomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK., Hoade Y; Research Department of Haematology, University College London Cancer Institute, London, UK., Zhu C; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK., Reading JL; Pre-Cancer Immunology Laboratory, UCL Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London, UK., Walker I; MRC Toxicology Unit, Cambridge, UK.; Cambridge University Hospitals NHS Trust, Cambridge, UK., Chapman M; MRC Toxicology Unit, Cambridge, UK.; Cambridge University Hospitals NHS Trust, Cambridge, UK., Ramasamy K; Oxford University Hospitals, NHS Foundation Trust, Oxford, UK., Herrero J; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK., Chain B; Division of Infection and Immunity, University College London, London, UK. b.chain@ucl.ac.uk.; Department of Computer Sciences, University College London, London, UK. b.chain@ucl.ac.uk., Quezada SA; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London, UK. s.quezada@ucl.ac.uk.; Immune Regulation and Tumour Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK. s.quezada@ucl.ac.uk., Yong KL; Research Department of Haematology, University College London Cancer Institute, London, UK. kwee.yong@ucl.ac.uk.; University College London Hospitals NHS Foundation Trust, London, UK. kwee.yong@ucl.ac.uk.
Source: Nature communications [Nat Commun] 2026 Feb 05; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Tumour-intrinsic features shape T cell differentiation through precursor to symptomatic multiple myeloma.
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  Data: <searchLink fieldCode="AU" term="%22Foster+KA%22">Foster KA</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Rees+E%22">Rees E</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Ainley+L%22">Ainley L</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Laidler+A%22">Laidler A</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Boyle+EM%22">Boyle EM</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Lee+L%22">Lee L</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Ward+G%22">Ward G</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Galas-Filipowicz+D%22">Galas-Filipowicz D</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Fitzsimons+E%22">Fitzsimons E</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Mikolajczak+A%22">Mikolajczak A</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Lyon+EJ%22">Lyon EJ</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Jankovic+D%22">Jankovic D</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Rahman+J%22">Rahman J</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Turakhia+M%22">Turakhia M</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Mehta+D%22">Mehta D</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Garrod-Ketchley+C%22">Garrod-Ketchley C</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Uddin+I%22">Uddin I</searchLink>; CRUK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK.; Genomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Beattie+G%22">Beattie G</searchLink>; CRUK City of London Centre Single Cell Genomics Facility, UCL Cancer Institute, University College London, London, UK.; Genomics Translational Technology Platform, UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Hoade+Y%22">Hoade Y</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Zhu+C%22">Zhu C</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK.; University College London Hospitals NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Reading+JL%22">Reading JL</searchLink>; Pre-Cancer Immunology Laboratory, UCL Cancer Institute, London, UK.; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Walker+I%22">Walker I</searchLink>; MRC Toxicology Unit, Cambridge, UK.; Cambridge University Hospitals NHS Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Chapman+M%22">Chapman M</searchLink>; MRC Toxicology Unit, Cambridge, UK.; Cambridge University Hospitals NHS Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Ramasamy+K%22">Ramasamy K</searchLink>; Oxford University Hospitals, NHS Foundation Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Herrero+J%22">Herrero J</searchLink>; Bill Lyons Informatics Centre, University College London Cancer Institute, London, UK.<br /><searchLink fieldCode="AU" term="%22Chain+B%22">Chain B</searchLink>; Division of Infection and Immunity, University College London, London, UK. b.chain@ucl.ac.uk.; Department of Computer Sciences, University College London, London, UK. b.chain@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Quezada+SA%22">Quezada SA</searchLink>; Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, London, UK. s.quezada@ucl.ac.uk.; Immune Regulation and Tumour Immunotherapy Group, Cancer Immunology Unit, Research Department of Haematology, University College London Cancer Institute, London, UK. s.quezada@ucl.ac.uk.<br /><searchLink fieldCode="AU" term="%22Yong+KL%22">Yong KL</searchLink>; Research Department of Haematology, University College London Cancer Institute, London, UK. kwee.yong@ucl.ac.uk.; University College London Hospitals NHS Foundation Trust, London, UK. kwee.yong@ucl.ac.uk.
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