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Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.

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Title: Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.
Authors: Thériault S; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.)., Holdcraft JA; Department of Biostatistics, School of Public Health, Boston University, MA (J.A.H., G.M.P.)., Sharipova D; Department of Animal Physiology, Institute of Biochemistry and Biology, University of Potsdam, Germany (D.S., S.A.-S.)., Faucherre A; Institut de Génomique Fonctionnelle, University of Montpellier, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, France (A. Faucherre, C.J.)., Debiec RM; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.)., Peloso GM; Department of Biostatistics, School of Public Health, Boston University, MA (J.A.H., G.M.P.)., Al-Kassou B; Department of Medicine II, Heart Center Bonn (B.A.-K., G.N.), University of Bonn and University Hospital Bonn, Germany., Aranki S; Brigham and Women's Hospital, Boston, MA (S.A., M.D.F., S.G.)., Ashikhmina Swan E; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN (E.A.S.)., Ballotta A; Centro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico Via Parea, Milan University, Italy (A.B.)., Bellino M; University Study of Salerno, Italy (M. Bellino)., Björck HM; Division of Cardiology, Center for Molecular Medicine, Department of Medicine (H.M.B., P.E.), Karolinska Institutet, Stockholm, Sweden.; Karolinska University Hospital, Solna, Sweden (H.M.B., P.E., A.F.-C.)., Boureau AS; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.)., Braund PS; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.)., Corriveau F; Université Laval, Quebec City, Canada (F.C.)., Dagenais F; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.)., Folkersen L; Nucleus Genomics, New York, NY (L.F.)., Forte A; University of Campania L. Vanvitelli, Naples, Italy (A. Forte, A.D.C.)., Francke MD; Brigham and Women's Hospital, Boston, MA (S.A., M.D.F., S.G.)., Frigiola A; Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Italy (A. Frigiola, C.d.V., F.P.)., Gorbatov S; Brigham and Women's Hospital, Boston, MA (S.A., M.D.F., S.G.)., Guo D; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.G., D.M., D.R.M., S.K.P.)., Habchi KM; New York-Presbyterian Weill Cornell Medical Center, New York, NY (K.M.H.)., Heydarpour M; Department of Medicine, Boston, MA (M.H.)., Isselbacher EM; Massachusetts General Hospital, Boston (E.M.I., T.S.)., Jopling C; Institut de Génomique Fonctionnelle, University of Montpellier, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, France (A. Faucherre, C.J.)., Laporte F; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.)., Le Scouarnec S; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.)., Li Z; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.)., Lichtner P; Helmholtz Munich, Neuherberg, Germany (P.L., S.W.)., Maj C; Institute of Human Genetics, Philipps University of Marburg, Germany (C.M., J.S.)., Manikpurage HD; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.)., Nelson CP; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.)., Nguyen TB; University of Colorado, Aurora (T.B.N.)., Norris RA; Medical University of South Carolina, Charleston (R.A.N.)., Ong CS; Yale University School of Medicine, New Haven, CT (C.S.O.)., Pibarot P; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.)., Roychowdhury T; Department of Internal Medicine, Division of Cardiology (T.R., I.S., C.J.W., B.Y.).; Department of Biology and Koita Centre for Digital Health, Trivedi School of Biosciences, Ashoka University, Sonepat, India (T.R.)., Sarubbi B; Department of Biology and Koita Centre for Digital Health, Trivedi School of Biosciences, Ashoka University, Sonepat, India (T.R.).; Adult Congenital Heart Disease and Congenital and Familial Arrhythmias Unit, Monaldi Hospital, Naples, Italy (B.S.)., Simonet F; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.)., Sundt T; Massachusetts General Hospital, Boston (E.M.I., T.S.)., Surakka I; Department of Internal Medicine, Division of Cardiology (T.R., I.S., C.J.W., B.Y.)., Tessler I; Sheba Medical center, Ramat Gan, Israel (I.T.)., Willer CJ; Department of Internal Medicine, Division of Cardiology (T.R., I.S., C.J.W., B.Y.)., Wittmann S; Helmholtz Munich, Neuherberg, Germany (P.L., S.W.)., Yang B; Department of Internal Medicine, Division of Cardiology (T.R., I.S., C.J.W., B.Y.)., Berezovets I; Department of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, University Medical Center Schleswig-Holstein, Germany (I.B., T.P., S.E.)., Doppler SA; Department of Cardiovascular Surgery, Institute Insure (S.A.D., M.D., M.K.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich., Dreßen M; Department of Cardiovascular Surgery, Institute Insure (S.A.D., M.D., M.K.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich., Knoll K; Department of Cardiovascular Diseases (K.K., H.S., T.T.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.; German Center for Cardiovascular Disease, Partner Site Munich Heart Alliance (K.K., H.S., M.K., T.T.)., Puehler T; Department of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, University Medical Center Schleswig-Holstein, Germany (I.B., T.P., S.E.)., Schunkert H; Department of Cardiovascular Diseases (K.K., H.S., T.T.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.; German Center for Cardiovascular Disease, Partner Site Munich Heart Alliance (K.K., H.S., M.K., T.T.)., Avierinos JF; Service de Cardiologie, Assistance Publique - Hôpitaux de Marseille, Hôpital de la Timone, Marseille, France (J.-F.A.)., Bissell MM; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (M.M.B.)., Bolger AP; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.)., Bossé Y; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.)., Bossone E; Department of Public Health, Faculty of Medicine, University of Naples 'Federico II,' Italy (E.B.)., Brion M; Xenética Cardiovascular, Instituto de Investigación Sanitaria de Santiago, Complexo Hositalario Universitario de Santiago, Santiago de Compostela, Spain (M.B.)., Citro R; Department of Medicine and Health Science, University of Molise, Campobasso, Italy (R.C.).; Department of Vascular Pathophysiology, Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli, Italy (R.C.)., de Vincentiis C; Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Italy (A. Frigiola, C.d.V., F.P.)., Deeb GM; Department of Cardiac Surgery (G.M.D.)., Della Corte A; University of Campania L. Vanvitelli, Naples, Italy (A. Forte, A.D.C.)., Dina C; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.)., Durst R; Cardiology Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel (R.D., D.G.)., Ensminger S; Department of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, University Medical Center Schleswig-Holstein, Germany (I.B., T.P., S.E.)., Eriksson P; Division of Cardiology, Center for Molecular Medicine, Department of Medicine (H.M.B., P.E.), Karolinska Institutet, Stockholm, Sweden.; Karolinska University Hospital, Solna, Sweden (H.M.B., P.E., A.F.-C.)., Evangelista A; Hospital Universitari Vall d'Hebron, Barcelona, Spain (A.E.)., Franco-Cereceda A; Department of Molecular Medicine and Surgery (A.F.-C.), Karolinska Institutet, Stockholm, Sweden.; Karolinska University Hospital, Solna, Sweden (H.M.B., P.E., A.F.-C.)., Gilon D; Cardiology Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel (R.D., D.G.)., Giusti B; Department of Experimental and Clinical Medicine, University of Florence, Italy (B.G., S.N.)., Hetherington SL; Kettering General Hospital National Health Service Foundation Trust, Kettering, United Kingdom (S.L.H.)., Huggins GS; Tufts Medical Center, Boston, MA (G.S.H.)., Krane M; Department of Cardiovascular Surgery, Institute Insure (S.A.D., M.D., M.K.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.; German Center for Cardiovascular Disease, Partner Site Munich Heart Alliance (K.K., H.S., M.K., T.T.)., Le Tourneau T; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.)., Limongelli G; Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy (G.L.)., Mathieu P; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.)., Messika-Zeitoun D; Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy (G.L.)., Michelena HI; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (H.I.M.)., Milewicz D; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.G., D.M., D.R.M., S.K.P.)., Muehlschlegel JD; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (J.D.M.)., Murdock DR; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.G., D.M., D.R.M., S.K.P.)., Nickenig G; Department of Medicine II, Heart Center Bonn (B.A.-K., G.N.), University of Bonn and University Hospital Bonn, Germany., Nistri S; Department of Experimental and Clinical Medicine, University of Florence, Italy (B.G., S.N.).; Centro Medico Strumentale Riabilitativo Veneto Medica, Altavilla Vicentina, Italy (S.N.)., Nöthen MM; Institute of Human Genetics (M.M.N., J.S.), University of Bonn and University Hospital Bonn, Germany., Pluchinotta F; Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Italy (A. Frigiola, C.d.V., F.P.)., Prakash SK; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.G., D.M., D.R.M., S.K.P.)., Samani NJ; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.)., Schott JJ; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.)., Webb TR; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.)., Zaffran S; Aix Marseille Université, Institut national de la santé et de la recherche médicale, Marseille Medical Genetics, U1251, France (S.Z.)., Abdelilah-Seyfried S; Department of Animal Physiology, Institute of Biochemistry and Biology, University of Potsdam, Germany (D.S., S.A.-S.)., Eagle K; Michigan Medicine, University of Michigan, Ann Arbor (K.E.)., Schumacher J; Institute of Human Genetics (M.M.N., J.S.), University of Bonn and University Hospital Bonn, Germany.; Institute of Human Genetics, Philipps University of Marburg, Germany (C.M., J.S.)., Trenkwalder T; Department of Cardiovascular Diseases (K.K., H.S., T.T.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.; German Center for Cardiovascular Disease, Partner Site Munich Heart Alliance (K.K., H.S., M.K., T.T.)., Body SC; Department of Anesthesiology, Boston University, MA (S.C.B.).
Source: Circulation [Circulation] 2026 Apr 07; Vol. 153 (14), pp. 1060-1076. Date of Electronic Publication: 2026 Feb 06.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
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AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Thériault+S%22">Thériault S</searchLink>; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.).<br /><searchLink fieldCode="AU" term="%22Holdcraft+JA%22">Holdcraft JA</searchLink>; Department of Biostatistics, School of Public Health, Boston University, MA (J.A.H., G.M.P.).<br /><searchLink fieldCode="AU" term="%22Sharipova+D%22">Sharipova D</searchLink>; Department of Animal Physiology, Institute of Biochemistry and Biology, University of Potsdam, Germany (D.S., S.A.-S.).<br /><searchLink fieldCode="AU" term="%22Faucherre+A%22">Faucherre A</searchLink>; Institut de Génomique Fonctionnelle, University of Montpellier, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, France (A. Faucherre, C.J.).<br /><searchLink fieldCode="AU" term="%22Debiec+RM%22">Debiec RM</searchLink>; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.).<br /><searchLink fieldCode="AU" term="%22Peloso+GM%22">Peloso GM</searchLink>; Department of Biostatistics, School of Public Health, Boston University, MA (J.A.H., G.M.P.).<br /><searchLink fieldCode="AU" term="%22Al-Kassou+B%22">Al-Kassou B</searchLink>; Department of Medicine II, Heart Center Bonn (B.A.-K., G.N.), University of Bonn and University Hospital Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Aranki+S%22">Aranki S</searchLink>; Brigham and Women's Hospital, Boston, MA (S.A., M.D.F., S.G.).<br /><searchLink fieldCode="AU" term="%22Ashikhmina+Swan+E%22">Ashikhmina Swan E</searchLink>; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN (E.A.S.).<br /><searchLink fieldCode="AU" term="%22Ballotta+A%22">Ballotta A</searchLink>; Centro Cardiologico Monzino Istituto di Ricovero e Cura a Carattere Scientifico Via Parea, Milan University, Italy (A.B.).<br /><searchLink fieldCode="AU" term="%22Bellino+M%22">Bellino M</searchLink>; University Study of Salerno, Italy (M. Bellino).<br /><searchLink fieldCode="AU" term="%22Björck+HM%22">Björck HM</searchLink>; Division of Cardiology, Center for Molecular Medicine, Department of Medicine (H.M.B., P.E.), Karolinska Institutet, Stockholm, Sweden.; Karolinska University Hospital, Solna, Sweden (H.M.B., P.E., A.F.-C.).<br /><searchLink fieldCode="AU" term="%22Boureau+AS%22">Boureau AS</searchLink>; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.).<br /><searchLink fieldCode="AU" term="%22Braund+PS%22">Braund PS</searchLink>; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.).<br /><searchLink fieldCode="AU" term="%22Corriveau+F%22">Corriveau F</searchLink>; Université Laval, Quebec City, Canada (F.C.).<br /><searchLink fieldCode="AU" term="%22Dagenais+F%22">Dagenais F</searchLink>; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.).<br /><searchLink fieldCode="AU" term="%22Folkersen+L%22">Folkersen L</searchLink>; Nucleus Genomics, New York, NY (L.F.).<br /><searchLink fieldCode="AU" term="%22Forte+A%22">Forte A</searchLink>; University of Campania L. Vanvitelli, Naples, Italy (A. Forte, A.D.C.).<br /><searchLink fieldCode="AU" term="%22Francke+MD%22">Francke MD</searchLink>; Brigham and Women's Hospital, Boston, MA (S.A., M.D.F., S.G.).<br /><searchLink fieldCode="AU" term="%22Frigiola+A%22">Frigiola A</searchLink>; Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Italy (A. Frigiola, C.d.V., F.P.).<br /><searchLink fieldCode="AU" term="%22Gorbatov+S%22">Gorbatov S</searchLink>; Brigham and Women's Hospital, Boston, MA (S.A., M.D.F., S.G.).<br /><searchLink fieldCode="AU" term="%22Guo+D%22">Guo D</searchLink>; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.G., D.M., D.R.M., S.K.P.).<br /><searchLink fieldCode="AU" term="%22Habchi+KM%22">Habchi KM</searchLink>; New York-Presbyterian Weill Cornell Medical Center, New York, NY (K.M.H.).<br /><searchLink fieldCode="AU" term="%22Heydarpour+M%22">Heydarpour M</searchLink>; Department of Medicine, Boston, MA (M.H.).<br /><searchLink fieldCode="AU" term="%22Isselbacher+EM%22">Isselbacher EM</searchLink>; Massachusetts General Hospital, Boston (E.M.I., T.S.).<br /><searchLink fieldCode="AU" term="%22Jopling+C%22">Jopling C</searchLink>; Institut de Génomique Fonctionnelle, University of Montpellier, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, France (A. Faucherre, C.J.).<br /><searchLink fieldCode="AU" term="%22Laporte+F%22">Laporte F</searchLink>; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.).<br /><searchLink fieldCode="AU" term="%22Le+Scouarnec+S%22">Le Scouarnec S</searchLink>; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.).<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.).<br /><searchLink fieldCode="AU" term="%22Lichtner+P%22">Lichtner P</searchLink>; Helmholtz Munich, Neuherberg, Germany (P.L., S.W.).<br /><searchLink fieldCode="AU" term="%22Maj+C%22">Maj C</searchLink>; Institute of Human Genetics, Philipps University of Marburg, Germany (C.M., J.S.).<br /><searchLink fieldCode="AU" term="%22Manikpurage+HD%22">Manikpurage HD</searchLink>; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.).<br /><searchLink fieldCode="AU" term="%22Nelson+CP%22">Nelson CP</searchLink>; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.).<br /><searchLink fieldCode="AU" term="%22Nguyen+TB%22">Nguyen TB</searchLink>; University of Colorado, Aurora (T.B.N.).<br /><searchLink fieldCode="AU" term="%22Norris+RA%22">Norris RA</searchLink>; Medical University of South Carolina, Charleston (R.A.N.).<br /><searchLink fieldCode="AU" term="%22Ong+CS%22">Ong CS</searchLink>; Yale University School of Medicine, New Haven, CT (C.S.O.).<br /><searchLink fieldCode="AU" term="%22Pibarot+P%22">Pibarot P</searchLink>; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.).<br /><searchLink fieldCode="AU" term="%22Roychowdhury+T%22">Roychowdhury T</searchLink>; Department of Internal Medicine, Division of Cardiology (T.R., I.S., C.J.W., B.Y.).; Department of Biology and Koita Centre for Digital Health, Trivedi School of Biosciences, Ashoka University, Sonepat, India (T.R.).<br /><searchLink fieldCode="AU" term="%22Sarubbi+B%22">Sarubbi B</searchLink>; Department of Biology and Koita Centre for Digital Health, Trivedi School of Biosciences, Ashoka University, Sonepat, India (T.R.).; Adult Congenital Heart Disease and Congenital and Familial Arrhythmias Unit, Monaldi Hospital, Naples, Italy (B.S.).<br /><searchLink fieldCode="AU" term="%22Simonet+F%22">Simonet F</searchLink>; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.).<br /><searchLink fieldCode="AU" term="%22Sundt+T%22">Sundt T</searchLink>; Massachusetts General Hospital, Boston (E.M.I., T.S.).<br /><searchLink fieldCode="AU" term="%22Surakka+I%22">Surakka I</searchLink>; Department of Internal Medicine, Division of Cardiology (T.R., I.S., C.J.W., B.Y.).<br /><searchLink fieldCode="AU" term="%22Tessler+I%22">Tessler I</searchLink>; Sheba Medical center, Ramat Gan, Israel (I.T.).<br /><searchLink fieldCode="AU" term="%22Willer+CJ%22">Willer CJ</searchLink>; Department of Internal Medicine, Division of Cardiology (T.R., I.S., C.J.W., B.Y.).<br /><searchLink fieldCode="AU" term="%22Wittmann+S%22">Wittmann S</searchLink>; Helmholtz Munich, Neuherberg, Germany (P.L., S.W.).<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Department of Internal Medicine, Division of Cardiology (T.R., I.S., C.J.W., B.Y.).<br /><searchLink fieldCode="AU" term="%22Berezovets+I%22">Berezovets I</searchLink>; Department of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, University Medical Center Schleswig-Holstein, Germany (I.B., T.P., S.E.).<br /><searchLink fieldCode="AU" term="%22Doppler+SA%22">Doppler SA</searchLink>; Department of Cardiovascular Surgery, Institute Insure (S.A.D., M.D., M.K.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.<br /><searchLink fieldCode="AU" term="%22Dreßen+M%22">Dreßen M</searchLink>; Department of Cardiovascular Surgery, Institute Insure (S.A.D., M.D., M.K.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.<br /><searchLink fieldCode="AU" term="%22Knoll+K%22">Knoll K</searchLink>; Department of Cardiovascular Diseases (K.K., H.S., T.T.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.; German Center for Cardiovascular Disease, Partner Site Munich Heart Alliance (K.K., H.S., M.K., T.T.).<br /><searchLink fieldCode="AU" term="%22Puehler+T%22">Puehler T</searchLink>; Department of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, University Medical Center Schleswig-Holstein, Germany (I.B., T.P., S.E.).<br /><searchLink fieldCode="AU" term="%22Schunkert+H%22">Schunkert H</searchLink>; Department of Cardiovascular Diseases (K.K., H.S., T.T.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.; German Center for Cardiovascular Disease, Partner Site Munich Heart Alliance (K.K., H.S., M.K., T.T.).<br /><searchLink fieldCode="AU" term="%22Avierinos+JF%22">Avierinos JF</searchLink>; Service de Cardiologie, Assistance Publique - Hôpitaux de Marseille, Hôpital de la Timone, Marseille, France (J.-F.A.).<br /><searchLink fieldCode="AU" term="%22Bissell+MM%22">Bissell MM</searchLink>; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, United Kingdom (M.M.B.).<br /><searchLink fieldCode="AU" term="%22Bolger+AP%22">Bolger AP</searchLink>; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.).<br /><searchLink fieldCode="AU" term="%22Bossé+Y%22">Bossé Y</searchLink>; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.).<br /><searchLink fieldCode="AU" term="%22Bossone+E%22">Bossone E</searchLink>; Department of Public Health, Faculty of Medicine, University of Naples 'Federico II,' Italy (E.B.).<br /><searchLink fieldCode="AU" term="%22Brion+M%22">Brion M</searchLink>; Xenética Cardiovascular, Instituto de Investigación Sanitaria de Santiago, Complexo Hositalario Universitario de Santiago, Santiago de Compostela, Spain (M.B.).<br /><searchLink fieldCode="AU" term="%22Citro+R%22">Citro R</searchLink>; Department of Medicine and Health Science, University of Molise, Campobasso, Italy (R.C.).; Department of Vascular Pathophysiology, Istituto di Ricovero e Cura a Carattere Scientifico Neuromed, Pozzilli, Italy (R.C.).<br /><searchLink fieldCode="AU" term="%22de+Vincentiis+C%22">de Vincentiis C</searchLink>; Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Italy (A. Frigiola, C.d.V., F.P.).<br /><searchLink fieldCode="AU" term="%22Deeb+GM%22">Deeb GM</searchLink>; Department of Cardiac Surgery (G.M.D.).<br /><searchLink fieldCode="AU" term="%22Della+Corte+A%22">Della Corte A</searchLink>; University of Campania L. Vanvitelli, Naples, Italy (A. Forte, A.D.C.).<br /><searchLink fieldCode="AU" term="%22Dina+C%22">Dina C</searchLink>; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.).<br /><searchLink fieldCode="AU" term="%22Durst+R%22">Durst R</searchLink>; Cardiology Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel (R.D., D.G.).<br /><searchLink fieldCode="AU" term="%22Ensminger+S%22">Ensminger S</searchLink>; Department of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, University Medical Center Schleswig-Holstein, Germany (I.B., T.P., S.E.).<br /><searchLink fieldCode="AU" term="%22Eriksson+P%22">Eriksson P</searchLink>; Division of Cardiology, Center for Molecular Medicine, Department of Medicine (H.M.B., P.E.), Karolinska Institutet, Stockholm, Sweden.; Karolinska University Hospital, Solna, Sweden (H.M.B., P.E., A.F.-C.).<br /><searchLink fieldCode="AU" term="%22Evangelista+A%22">Evangelista A</searchLink>; Hospital Universitari Vall d'Hebron, Barcelona, Spain (A.E.).<br /><searchLink fieldCode="AU" term="%22Franco-Cereceda+A%22">Franco-Cereceda A</searchLink>; Department of Molecular Medicine and Surgery (A.F.-C.), Karolinska Institutet, Stockholm, Sweden.; Karolinska University Hospital, Solna, Sweden (H.M.B., P.E., A.F.-C.).<br /><searchLink fieldCode="AU" term="%22Gilon+D%22">Gilon D</searchLink>; Cardiology Department, Hadassah Hebrew University Medical Center, Jerusalem, Israel (R.D., D.G.).<br /><searchLink fieldCode="AU" term="%22Giusti+B%22">Giusti B</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Italy (B.G., S.N.).<br /><searchLink fieldCode="AU" term="%22Hetherington+SL%22">Hetherington SL</searchLink>; Kettering General Hospital National Health Service Foundation Trust, Kettering, United Kingdom (S.L.H.).<br /><searchLink fieldCode="AU" term="%22Huggins+GS%22">Huggins GS</searchLink>; Tufts Medical Center, Boston, MA (G.S.H.).<br /><searchLink fieldCode="AU" term="%22Krane+M%22">Krane M</searchLink>; Department of Cardiovascular Surgery, Institute Insure (S.A.D., M.D., M.K.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.; German Center for Cardiovascular Disease, Partner Site Munich Heart Alliance (K.K., H.S., M.K., T.T.).<br /><searchLink fieldCode="AU" term="%22Le+Tourneau+T%22">Le Tourneau T</searchLink>; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.).<br /><searchLink fieldCode="AU" term="%22Limongelli+G%22">Limongelli G</searchLink>; Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy (G.L.).<br /><searchLink fieldCode="AU" term="%22Mathieu+P%22">Mathieu P</searchLink>; Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval (S.T., F.D., Z.L., H.D.M., P.P., Y.B., P.M.).<br /><searchLink fieldCode="AU" term="%22Messika-Zeitoun+D%22">Messika-Zeitoun D</searchLink>; Department of Translational Medical Sciences, University of Campania Luigi Vanvitelli, Naples, Italy (G.L.).<br /><searchLink fieldCode="AU" term="%22Michelena+HI%22">Michelena HI</searchLink>; Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN (H.I.M.).<br /><searchLink fieldCode="AU" term="%22Milewicz+D%22">Milewicz D</searchLink>; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.G., D.M., D.R.M., S.K.P.).<br /><searchLink fieldCode="AU" term="%22Muehlschlegel+JD%22">Muehlschlegel JD</searchLink>; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (J.D.M.).<br /><searchLink fieldCode="AU" term="%22Murdock+DR%22">Murdock DR</searchLink>; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.G., D.M., D.R.M., S.K.P.).<br /><searchLink fieldCode="AU" term="%22Nickenig+G%22">Nickenig G</searchLink>; Department of Medicine II, Heart Center Bonn (B.A.-K., G.N.), University of Bonn and University Hospital Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Nistri+S%22">Nistri S</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Italy (B.G., S.N.).; Centro Medico Strumentale Riabilitativo Veneto Medica, Altavilla Vicentina, Italy (S.N.).<br /><searchLink fieldCode="AU" term="%22Nöthen+MM%22">Nöthen MM</searchLink>; Institute of Human Genetics (M.M.N., J.S.), University of Bonn and University Hospital Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Pluchinotta+F%22">Pluchinotta F</searchLink>; Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Donato, San Donato Milanese, Italy (A. Frigiola, C.d.V., F.P.).<br /><searchLink fieldCode="AU" term="%22Prakash+SK%22">Prakash SK</searchLink>; Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston (D.G., D.M., D.R.M., S.K.P.).<br /><searchLink fieldCode="AU" term="%22Samani+NJ%22">Samani NJ</searchLink>; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.).<br /><searchLink fieldCode="AU" term="%22Schott+JJ%22">Schott JJ</searchLink>; Nantes Université, CHU Nantes, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, L'Institut du Thorax, France (A.S.B., F.L., S.L.S., F.S., C.D., T.L.T., J.-J.S.).<br /><searchLink fieldCode="AU" term="%22Webb+TR%22">Webb TR</searchLink>; Department of Cardiovascular Sciences, Leicester British Heart Foundation Centre of Research Excellence and National Institute for Health and Care Research Leicester Biomedical Research Centre, University of Leicester (R.M.D., P.S.B., C.P.N., A.P.B., N.J.S., T.R.W.).<br /><searchLink fieldCode="AU" term="%22Zaffran+S%22">Zaffran S</searchLink>; Aix Marseille Université, Institut national de la santé et de la recherche médicale, Marseille Medical Genetics, U1251, France (S.Z.).<br /><searchLink fieldCode="AU" term="%22Abdelilah-Seyfried+S%22">Abdelilah-Seyfried S</searchLink>; Department of Animal Physiology, Institute of Biochemistry and Biology, University of Potsdam, Germany (D.S., S.A.-S.).<br /><searchLink fieldCode="AU" term="%22Eagle+K%22">Eagle K</searchLink>; Michigan Medicine, University of Michigan, Ann Arbor (K.E.).<br /><searchLink fieldCode="AU" term="%22Schumacher+J%22">Schumacher J</searchLink>; Institute of Human Genetics (M.M.N., J.S.), University of Bonn and University Hospital Bonn, Germany.; Institute of Human Genetics, Philipps University of Marburg, Germany (C.M., J.S.).<br /><searchLink fieldCode="AU" term="%22Trenkwalder+T%22">Trenkwalder T</searchLink>; Department of Cardiovascular Diseases (K.K., H.S., T.T.), German Heart Center Munich, School of Medicine and Health, Technical University of Munich University Hospital, Technical University of Munich.; German Center for Cardiovascular Disease, Partner Site Munich Heart Alliance (K.K., H.S., M.K., T.T.).<br /><searchLink fieldCode="AU" term="%22Body+SC%22">Body SC</searchLink>; Department of Anesthesiology, Boston University, MA (S.C.B.).
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  Data: <searchLink fieldCode="JN" term="%220147763%22">Circulation</searchLink> [Circulation] 2026 Apr 07; Vol. 153 (14), pp. 1060-1076. <i>Date of Electronic Publication: </i>2026 Feb 06.
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  Data: Journal Article; Meta-Analysis
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lippincott+Williams+%26+Wilkins%22">Lippincott Williams & Wilkins </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0147763 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1524-4539 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200097322%22">00097322 </searchLink><i>NLM ISO Abbreviation: </i>Circulation <i>Subsets: </i>MEDLINE
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        Value: 10.1161/CIRCULATIONAHA.125.074752
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        Text: English
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      – TitleFull: Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve.
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      – PersonEntity:
          Name:
            NameFull: Giusti B
      – PersonEntity:
          Name:
            NameFull: Hetherington SL
      – PersonEntity:
          Name:
            NameFull: Huggins GS
      – PersonEntity:
          Name:
            NameFull: Krane M
      – PersonEntity:
          Name:
            NameFull: Le Tourneau T
      – PersonEntity:
          Name:
            NameFull: Limongelli G
      – PersonEntity:
          Name:
            NameFull: Mathieu P
      – PersonEntity:
          Name:
            NameFull: Messika-Zeitoun D
      – PersonEntity:
          Name:
            NameFull: Michelena HI
      – PersonEntity:
          Name:
            NameFull: Milewicz D
      – PersonEntity:
          Name:
            NameFull: Muehlschlegel JD
      – PersonEntity:
          Name:
            NameFull: Murdock DR
      – PersonEntity:
          Name:
            NameFull: Nickenig G
      – PersonEntity:
          Name:
            NameFull: Nistri S
      – PersonEntity:
          Name:
            NameFull: Nöthen MM
      – PersonEntity:
          Name:
            NameFull: Pluchinotta F
      – PersonEntity:
          Name:
            NameFull: Prakash SK
      – PersonEntity:
          Name:
            NameFull: Samani NJ
      – PersonEntity:
          Name:
            NameFull: Schott JJ
      – PersonEntity:
          Name:
            NameFull: Webb TR
      – PersonEntity:
          Name:
            NameFull: Zaffran S
      – PersonEntity:
          Name:
            NameFull: Abdelilah-Seyfried S
      – PersonEntity:
          Name:
            NameFull: Eagle K
      – PersonEntity:
          Name:
            NameFull: Schumacher J
      – PersonEntity:
          Name:
            NameFull: Trenkwalder T
      – PersonEntity:
          Name:
            NameFull: Body SC
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 07
              M: 04
              Text: 2026 Apr 07
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1524-4539
          Numbering:
            – Type: volume
              Value: 153
            – Type: issue
              Value: 14
          Titles:
            – TitleFull: Circulation
              Type: main
ResultId 1