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A resource of "bottom-line" variant associations for 1,281 complex traits by integrating data across published genome-wide association studies.

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Title: A resource of "bottom-line" variant associations for 1,281 complex traits by integrating data across published genome-wide association studies.
Authors: Nguyen T; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Cardiomyopathy and Arrhythmia, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.; Genetic Epidemiology, Department of Psychiatry, Amsterdam UMC, University of Amsterdam, The Netherlands., Büyükgöl F; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital Munich, Munich, Germany.; Institute of Translational Genomics, Computational Health Center, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Smadbeck P; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Massung J; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Costanzo MC; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ruiz M; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dornbos P; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Regeneron Genetics Center, Tarrytown, New York, USA., Yoshiji S; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Human Genetics, McGill University, Montréal, Québec, Canada., Koesterer R; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen TL; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jang D; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hoang Q; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ji Y; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., McMahon A; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Sengupta S; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Yin X; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, Lianyungang Medical-Education Innovation Center, Nanjing Medical University, Nanjing, China.; Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, Nanjing, China., Ryan B; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Welch RP; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Treur J; Genetic Epidemiology, Department of Psychiatry, Amsterdam UMC, University of Amsterdam, The Netherlands., Bezzina CR; Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Cardiomyopathy and Arrhythmia, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands., Abecasis G; Regeneron Genetics Center, Tarrytown, New York, USA.; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Boehnke M; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Burtt NP; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Flannick J; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Source: Research square [Res Sq] 2026 Jan 22. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A resource of "bottom-line" variant associations for 1,281 complex traits by integrating data across published genome-wide association studies.
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  Data: <searchLink fieldCode="AU" term="%22Nguyen+T%22">Nguyen T</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Cardiomyopathy and Arrhythmia, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.; Genetic Epidemiology, Department of Psychiatry, Amsterdam UMC, University of Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Büyükgöl+F%22">Büyükgöl F</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital Munich, Munich, Germany.; Institute of Translational Genomics, Computational Health Center, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Smadbeck+P%22">Smadbeck P</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Massung+J%22">Massung J</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Costanzo+MC%22">Costanzo MC</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ruiz+M%22">Ruiz M</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Dornbos+P%22">Dornbos P</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.; Regeneron Genetics Center, Tarrytown, New York, USA.<br /><searchLink fieldCode="AU" term="%22Yoshiji+S%22">Yoshiji S</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Human Genetics, McGill University, Montréal, Québec, Canada.<br /><searchLink fieldCode="AU" term="%22Koesterer+R%22">Koesterer R</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Nguyen+TL%22">Nguyen TL</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jang+D%22">Jang D</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hoang+Q%22">Hoang Q</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Ji+Y%22">Ji Y</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22McMahon+A%22">McMahon A</searchLink>; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.<br /><searchLink fieldCode="AU" term="%22Sengupta+S%22">Sengupta S</searchLink>; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Yin+X%22">Yin X</searchLink>; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, Lianyungang Medical-Education Innovation Center, Nanjing Medical University, Nanjing, China.; Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ryan+B%22">Ryan B</searchLink>; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Welch+RP%22">Welch RP</searchLink>; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Treur+J%22">Treur J</searchLink>; Genetic Epidemiology, Department of Psychiatry, Amsterdam UMC, University of Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Bezzina+CR%22">Bezzina CR</searchLink>; Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Cardiomyopathy and Arrhythmia, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Abecasis+G%22">Abecasis G</searchLink>; Regeneron Genetics Center, Tarrytown, New York, USA.; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Boehnke+M%22">Boehnke M</searchLink>; Department of Biostatistics and The Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.<br /><searchLink fieldCode="AU" term="%22Burtt+NP%22">Burtt NP</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Flannick+J%22">Flannick J</searchLink>; Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
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              Text: 2026 Jan 22
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