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A modular tissue-clearing framework integrated with light-field microscopy enables rapid volumetric phenotyping of cardiac tissue.

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Title: A modular tissue-clearing framework integrated with light-field microscopy enables rapid volumetric phenotyping of cardiac tissue.
Authors: Lin S; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Schichines D; Department of Plant and Microbial Biology, University of California, Berkeley, CA, USA.; Biological Imaging Facility, University of California, Berkeley CA, USA., Hsu HM; Division of Research Microscopy Solutions, Carl Zeiss Co., Ltd., Hsinchu, Taiwan., Hung YL; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan., Chowdhury K; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Lin IT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Wang CJ; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Graduate Institute of Life Sciences, National Defense Medical University, Taipei, Taiwan., Tsai MJ; Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan., Liu ZY; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA., Yang KC; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan., Lai SB; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen BC; Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan., Heald R; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Source: Research square [Res Sq] 2026 Jan 16. Date of Electronic Publication: 2026 Jan 16.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A modular tissue-clearing framework integrated with light-field microscopy enables rapid volumetric phenotyping of cardiac tissue.
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  Data: <searchLink fieldCode="AU" term="%22Lin+S%22">Lin S</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Schichines+D%22">Schichines D</searchLink>; Department of Plant and Microbial Biology, University of California, Berkeley, CA, USA.; Biological Imaging Facility, University of California, Berkeley CA, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+HM%22">Hsu HM</searchLink>; Division of Research Microscopy Solutions, Carl Zeiss Co., Ltd., Hsinchu, Taiwan.<br /><searchLink fieldCode="AU" term="%22Hung+YL%22">Hung YL</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chowdhury+K%22">Chowdhury K</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lin+IT%22">Lin IT</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Wang+CJ%22">Wang CJ</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Graduate Institute of Life Sciences, National Defense Medical University, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+MJ%22">Tsai MJ</searchLink>; Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Liu+ZY%22">Liu ZY</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.<br /><searchLink fieldCode="AU" term="%22Yang+KC%22">Yang KC</searchLink>; Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine, Taipei, Taiwan.; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Lai+SB%22">Lai SB</searchLink>; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+BC%22">Chen BC</searchLink>; Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.<br /><searchLink fieldCode="AU" term="%22Heald+R%22">Heald R</searchLink>; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
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  Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101768035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2693-5015 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2226935015%22">26935015 </searchLink><i>NLM ISO Abbreviation: </i>Res Sq <i>Subsets: </i>PubMed not MEDLINE
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        Value: 10.21203/rs.3.rs-8566379/v1
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        Text: English
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              M: 01
              Text: 2026 Jan 16
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