Multimodal single-cell and spatial profiling reveals altered T cell-mediated immunity and B-cell follicular architecture in non-metastatic lymph nodes of patients with aggressive non-small cell lung cancer.
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| Title: | Multimodal single-cell and spatial profiling reveals altered T cell-mediated immunity and B-cell follicular architecture in non-metastatic lymph nodes of patients with aggressive non-small cell lung cancer. |
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| Authors: | Xi ZH; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Koga Y; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., McDermott S; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Kane EE; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Pfefferkorn R; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Billatos E; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Medicine, Section of Pulmonary and Critical Care Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Hosking PR; Department of Pathology& Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA., Beane JE; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Burks EJ; Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA., Mazzilli SA; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Suzuki K; INOVA, Department of Surgery, Division of Thoracic Surgery, Falls Church, VA, USA., Campbell JD; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. |
| Source: | MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jan 18. Date of Electronic Publication: 2026 Jan 18. |
| Publication Type: | Journal Article; Preprint |
| Journal Info: | Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41646724 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Multimodal single-cell and spatial profiling reveals altered T cell-mediated immunity and B-cell follicular architecture in non-metastatic lymph nodes of patients with aggressive non-small cell lung cancer. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Xi+ZH%22">Xi ZH</searchLink>; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Koga+Y%22">Koga Y</searchLink>; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22McDermott+S%22">McDermott S</searchLink>; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Kane+EE%22">Kane EE</searchLink>; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Pfefferkorn+R%22">Pfefferkorn R</searchLink>; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Billatos+E%22">Billatos E</searchLink>; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Medicine, Section of Pulmonary and Critical Care Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hosking+PR%22">Hosking PR</searchLink>; Department of Pathology& Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.<br /><searchLink fieldCode="AU" term="%22Beane+JE%22">Beane JE</searchLink>; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Burks+EJ%22">Burks EJ</searchLink>; Department of Pathology & Laboratory Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Mazzilli+SA%22">Mazzilli SA</searchLink>; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Suzuki+K%22">Suzuki K</searchLink>; INOVA, Department of Surgery, Division of Thoracic Surgery, Falls Church, VA, USA.<br /><searchLink fieldCode="AU" term="%22Campbell+JD%22">Campbell JD</searchLink>; Department of Medicine, Section of Computational Biomedicine, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101767986%22">MedRxiv : the preprint server for health sciences</searchLink> [medRxiv] 2026 Jan 18. <i>Date of Electronic Publication: </i>2026 Jan 18. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Preprint – Name: TitleSource Label: Journal Info Group: Src Data: <i>Country of Publication: </i>United States <i>NLM ID: </i>101767986 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>NLM ISO Abbreviation: </i>medRxiv <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41646724 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.64898/2026.01.12.25343268 Languages: – Code: eng Text: English Titles: – TitleFull: Multimodal single-cell and spatial profiling reveals altered T cell-mediated immunity and B-cell follicular architecture in non-metastatic lymph nodes of patients with aggressive non-small cell lung cancer. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Xi ZH – PersonEntity: Name: NameFull: Koga Y – PersonEntity: Name: NameFull: McDermott S – PersonEntity: Name: NameFull: Kane EE – PersonEntity: Name: NameFull: Pfefferkorn R – PersonEntity: Name: NameFull: Billatos E – PersonEntity: Name: NameFull: Hosking PR – PersonEntity: Name: NameFull: Beane JE – PersonEntity: Name: NameFull: Burks EJ – PersonEntity: Name: NameFull: Mazzilli SA – PersonEntity: Name: NameFull: Suzuki K – PersonEntity: Name: NameFull: Campbell JD IsPartOfRelationships: – BibEntity: Dates: – D: 18 M: 01 Text: 2026 Jan 18 Type: published Y: 2026 Titles: – TitleFull: MedRxiv : the preprint server for health sciences Type: main |
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