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Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex.

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Title: Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex.
Authors: Rai A; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Iatrou A; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.; Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Arzeta IV; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Bartlett AL; Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Banahan J; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Desai V; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Pantano L; Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Castanho I; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Yeganeh PN; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Ploumakis A; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Spatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Wang S; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Spatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., de Amaral AA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Spatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA., Kalavros N; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Spatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Nagalakshmi SU; Spatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Tsvetkov P; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Berretta S; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA., Solomon IH; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA., Hide W; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02215, USA., Vlachos IS; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Spatial Technologies Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02215, USA.; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Slack FJ; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02215, USA., Ozdemir R; Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Sui SH; Harvard Chan Bioinformatics Core, Harvard T.H. Chan School of Public Health, Boston, MA 02215, USA., Daskalakis NP; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.; Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mavrikaki M; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02215, USA.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 12. Date of Electronic Publication: 2026 Jan 12.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Aging-related Transcriptomic Changes with Spatial Resolution in the Human Prefrontal Cortex.
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Chan School of Public Health, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Daskalakis+NP%22">Daskalakis NP</searchLink>; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA.; Department of Pharmacology, Physiology and Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Department of Medicine (Biomedical Genetics), Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Mavrikaki+M%22">Mavrikaki M</searchLink>; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02215, USA.
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