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Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis.

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Title: Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis.
Authors: Grant DW; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK., Tan S; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.; Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK., Ramage DE; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK., Li MZ; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur Boston, MA 02115, USA., Di Y; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK., Tchasovnikarova IA; The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK., Weekes MP; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK., Elledge SJ; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur Boston, MA 02115, USA., Warren AJ; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.; Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK., Timms RT; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 14. Date of Electronic Publication: 2026 Jan 14.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis.
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  Data: <searchLink fieldCode="AU" term="%22Grant+DW%22">Grant DW</searchLink>; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Tan+S%22">Tan S</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.; Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Ramage+DE%22">Ramage DE</searchLink>; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Li+MZ%22">Li MZ</searchLink>; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Di+Y%22">Di Y</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Tchasovnikarova+IA%22">Tchasovnikarova IA</searchLink>; The Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK.<br /><searchLink fieldCode="AU" term="%22Weekes+MP%22">Weekes MP</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.<br /><searchLink fieldCode="AU" term="%22Elledge+SJ%22">Elledge SJ</searchLink>; Department of Genetics, Harvard Medical School, Division of Genetics, Brigham and Women's Hospital, Howard Hughes Medical Institute, 77 Avenue Louis Pasteur Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Warren+AJ%22">Warren AJ</searchLink>; Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge, CB2 0XY, UK.; Department of Haematology, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.; Cambridge Stem Cell Institute, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.<br /><searchLink fieldCode="AU" term="%22Timms+RT%22">Timms RT</searchLink>; Cambridge Institute of Therapeutic Immunology and Infectious Disease, Department of Medicine, University of Cambridge, Puddicombe Way, Cambridge, CB2 0AW, UK.
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              Text: 2026 Jan 14
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