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NR4A1 limits CD8⁺ T Cell effector responses and protection in tuberculosis.

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Title: NR4A1 limits CD8⁺ T Cell effector responses and protection in tuberculosis.
Authors: Fatima S; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Chen Y; A*STAR Infectious Diseases Labs (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Smulan L; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Satish B; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Jameson M; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Saini S; A*STAR Infectious Diseases Labs (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore., Johnson C; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Tay A; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore., Foo S; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore., Rahmathulla H; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore., Balachander A; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore., Howland SW; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore., Kornfeld H; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; These authors jointly supervised this work: Hardy Kornfeld and Amit Singhal., Singhal A; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; A*STAR Infectious Diseases Labs (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore, 308232, Republic of Singapore.; These authors jointly supervised this work: Hardy Kornfeld and Amit Singhal.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 13. Date of Electronic Publication: 2026 Jan 13.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: NR4A1 limits CD8⁺ T Cell effector responses and protection in tuberculosis.
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  Data: <searchLink fieldCode="AU" term="%22Fatima+S%22">Fatima S</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; A*STAR Infectious Diseases Labs (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.<br /><searchLink fieldCode="AU" term="%22Smulan+L%22">Smulan L</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Satish+B%22">Satish B</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Jameson+M%22">Jameson M</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Saini+S%22">Saini S</searchLink>; A*STAR Infectious Diseases Labs (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.<br /><searchLink fieldCode="AU" term="%22Johnson+C%22">Johnson C</searchLink>; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.<br /><searchLink fieldCode="AU" term="%22Tay+A%22">Tay A</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Foo+S%22">Foo S</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Rahmathulla+H%22">Rahmathulla H</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Balachander+A%22">Balachander A</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Howland+SW%22">Howland SW</searchLink>; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.<br /><searchLink fieldCode="AU" term="%22Kornfeld+H%22">Kornfeld H</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; These authors jointly supervised this work: Hardy Kornfeld and Amit Singhal.<br /><searchLink fieldCode="AU" term="%22Singhal+A%22">Singhal A</searchLink>; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; A*STAR Infectious Diseases Labs (ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore, 138648, Singapore.; Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore, 138684, Republic of Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University (NTU), Singapore, 308232, Republic of Singapore.; These authors jointly supervised this work: Hardy Kornfeld and Amit Singhal.
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              Text: 2026 Jan 13
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