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A non-canonical EZH2/TRIM28 epigenetic axis drives heparan sulfate remodeling and melanoma metastasis.

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Title: A non-canonical EZH2/TRIM28 epigenetic axis drives heparan sulfate remodeling and melanoma metastasis.
Authors: Patel NG; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States., Drakaki A; Department of Medical Biochemistry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Valummel F; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States., Moore JC; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States., Basu A; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States., Hu B; Massey Cancer Center, Virginia Commonwealth University; Richmond, VA, United States., Dong X; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States., Zhao P; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States., Botman M; Department of Medical Biochemistry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Spector E; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States., Mochel MC; Department of Pathology, Virginia Commonwealth University; Richmond, VA, United States., Wells L; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States., Koblinski JE; Massey Cancer Center, Virginia Commonwealth University; Richmond, VA, United States.; Department of Pathology, Virginia Commonwealth University; Richmond, VA, United States., Hoeksema MA; Department of Medical Biochemistry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Weiss RJ; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 22. Date of Electronic Publication: 2026 Jan 22.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: A non-canonical EZH2/TRIM28 epigenetic axis drives heparan sulfate remodeling and melanoma metastasis.
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  Data: <searchLink fieldCode="AU" term="%22Patel+NG%22">Patel NG</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.<br /><searchLink fieldCode="AU" term="%22Drakaki+A%22">Drakaki A</searchLink>; Department of Medical Biochemistry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Valummel+F%22">Valummel F</searchLink>; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.<br /><searchLink fieldCode="AU" term="%22Moore+JC%22">Moore JC</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.<br /><searchLink fieldCode="AU" term="%22Basu+A%22">Basu A</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.<br /><searchLink fieldCode="AU" term="%22Hu+B%22">Hu B</searchLink>; Massey Cancer Center, Virginia Commonwealth University; Richmond, VA, United States.<br /><searchLink fieldCode="AU" term="%22Dong+X%22">Dong X</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.<br /><searchLink fieldCode="AU" term="%22Zhao+P%22">Zhao P</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.<br /><searchLink fieldCode="AU" term="%22Botman+M%22">Botman M</searchLink>; Department of Medical Biochemistry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Spector+E%22">Spector E</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.<br /><searchLink fieldCode="AU" term="%22Mochel+MC%22">Mochel MC</searchLink>; Department of Pathology, Virginia Commonwealth University; Richmond, VA, United States.<br /><searchLink fieldCode="AU" term="%22Wells+L%22">Wells L</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.<br /><searchLink fieldCode="AU" term="%22Koblinski+JE%22">Koblinski JE</searchLink>; Massey Cancer Center, Virginia Commonwealth University; Richmond, VA, United States.; Department of Pathology, Virginia Commonwealth University; Richmond, VA, United States.<br /><searchLink fieldCode="AU" term="%22Hoeksema+MA%22">Hoeksema MA</searchLink>; Department of Medical Biochemistry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Weiss+RJ%22">Weiss RJ</searchLink>; Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602, United States.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, United States.
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