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The Berlin-Hannover ICANS severity assessment-a novel bedside test to evaluate CAR T-cell-associated neurotoxicity.

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Title: The Berlin-Hannover ICANS severity assessment-a novel bedside test to evaluate CAR T-cell-associated neurotoxicity.
Authors: Völker L; Department of Neurology, Hannover Medical School, Hannover, Germany.; KlinStrucMed Program, Dean's Office for Academic Career Development, Hannover Medical School, Hannover, Germany., Müller-Jensen L; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Carl S; Department of Neurology, Hannover Medical School, Hannover, Germany., Nay S; Department of Neurology, Hannover Medical School, Hannover, Germany., Möllenkamp TM; Department of Neurology, Hannover Medical School, Hannover, Germany.; Department of Neurology, University Hospital Munster, Munster, Germany., Schultze-Florey C; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Grote-Levi L; Department of Neurology, Hannover Medical School, Hannover, Germany., Jendretzky KF; Department of Neurology, Hannover Medical School, Hannover, Germany., Konen FF; Department of Neurology, Hannover Medical School, Hannover, Germany., Könecke C; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Eder M; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Panagiota V; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Heidel FH; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany., Bullinger L; Department of Haematology, Oncology and Tumour Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Damm F; Department of Haematology, Oncology and Tumour Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Frick M; Department of Haematology, Oncology and Tumour Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Penack O; Department of Haematology, Oncology and Tumour Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Ludwig R; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Buß EA; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany., Boehmerle W; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Endres M; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; German Centre for Cardiovascular Diseases (DZHK), Berlin, Germany.; German Center for Mental Health (DZPG), Berlin, Germany., Gudi V; Department of Neurology, Hannover Medical School, Hannover, Germany., Huehnchen P; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany., Skripuletz T; Department of Neurology, Hannover Medical School, Hannover, Germany., Möhn N; Department of Neurology, Hannover Medical School, Hannover, Germany.; Department of Neurology, University Hospital Bonn, Bonn, Germany.
Source: Frontiers in neurology [Front Neurol] 2026 Jan 21; Vol. 17, pp. 1726779. Date of Electronic Publication: 2026 Jan 21 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101546899 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2295 (Print) Linking ISSN: 16642295 NLM ISO Abbreviation: Front Neurol Subsets: PubMed not MEDLINE
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  Data: The Berlin-Hannover ICANS severity assessment-a novel bedside test to evaluate CAR T-cell-associated neurotoxicity.
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  Data: <searchLink fieldCode="AU" term="%22Völker+L%22">Völker L</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.; KlinStrucMed Program, Dean's Office for Academic Career Development, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Müller-Jensen+L%22">Müller-Jensen L</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Carl+S%22">Carl S</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Nay+S%22">Nay S</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Möllenkamp+TM%22">Möllenkamp TM</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.; Department of Neurology, University Hospital Munster, Munster, Germany.<br /><searchLink fieldCode="AU" term="%22Schultze-Florey+C%22">Schultze-Florey C</searchLink>; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Grote-Levi+L%22">Grote-Levi L</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Jendretzky+KF%22">Jendretzky KF</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Konen+FF%22">Konen FF</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Könecke+C%22">Könecke C</searchLink>; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Eder+M%22">Eder M</searchLink>; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Panagiota+V%22">Panagiota V</searchLink>; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Heidel+FH%22">Heidel FH</searchLink>; Department of Haematology, Haemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Bullinger+L%22">Bullinger L</searchLink>; Department of Haematology, Oncology and Tumour Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Damm+F%22">Damm F</searchLink>; Department of Haematology, Oncology and Tumour Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Frick+M%22">Frick M</searchLink>; Department of Haematology, Oncology and Tumour Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Penack+O%22">Penack O</searchLink>; Department of Haematology, Oncology and Tumour Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Ludwig+R%22">Ludwig R</searchLink>; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Buß+EA%22">Buß EA</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Boehmerle+W%22">Boehmerle W</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Endres+M%22">Endres M</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.; Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.; German Centre for Cardiovascular Diseases (DZHK), Berlin, Germany.; German Center for Mental Health (DZPG), Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Gudi+V%22">Gudi V</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Huehnchen+P%22">Huehnchen P</searchLink>; Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Klinik für Neurologie mit Experimenteller Neurologie, Berlin, Germany.; Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Skripuletz+T%22">Skripuletz T</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Möhn+N%22">Möhn N</searchLink>; Department of Neurology, Hannover Medical School, Hannover, Germany.; Department of Neurology, University Hospital Bonn, Bonn, Germany.
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