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NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopathy mouse model.

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Title: NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopathy mouse model.
Authors: López-Sampere Y; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain., Mengod Soler P; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain., Roca-Pereira S; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain., Vinyals A; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain., Mato-Blanco X; Neurogenomics Group, Hospital del Mar Research Institute, Parc de Recerca Biomèdica de Barcelona (PRBB), Dr. Aiguader, 88, Barcelona, Catalonia, 08003, Spain., Vela-Martínez M; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain., Dakterzada F; Cognition and Behaviour Study Group - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain., Romero L; Cognition and Behaviour Study Group - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain., Santamaría E; Proteomics Unit, Clinical Neuroproteomics Laboratory, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA)., Pamplona, Navarra, 31008, Spain., Fernández-Irigoyen J; Proteomics Unit, Clinical Neuroproteomics Laboratory, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA)., Pamplona, Navarra, 31008, Spain., Ferrer I; Department of Pathology and Experimental Therapeutics - Bellvitge Faculty, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, 08907, Spain., Povedano M; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, 08907, Spain., Del Rio JA; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Science Park of Barcelona, Barcelona, 08028, Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain., Santpere G; Neurogenomics Group, Hospital del Mar Research Institute, Parc de Recerca Biomèdica de Barcelona (PRBB), Dr. Aiguader, 88, Barcelona, Catalonia, 08003, Spain., Portero-Otín M; Metabolic Pathophysiology Research Group, Department of Experimental Medicine, University of Lleida - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain., Piñol-Ripoll G; Cognition and Behaviour Study Group - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain. Electronic address: gerard_437302@hotmail.com., Andrés-Benito P; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Cognition and Behaviour Study Group - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain; Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Science Park of Barcelona, Barcelona, 08028, Spain. Electronic address: pol.andres.benito@gmail.com.
Source: Redox biology [Redox Biol] 2026 Apr; Vol. 91, pp. 104068. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: NRF2 deficit prevents pathologic Tau seeding and spreading in an induced tauopathy mouse model.
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  Data: <searchLink fieldCode="AU" term="%22López-Sampere+Y%22">López-Sampere Y</searchLink>; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain.<br /><searchLink fieldCode="AU" term="%22Mengod+Soler+P%22">Mengod Soler P</searchLink>; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain.<br /><searchLink fieldCode="AU" term="%22Roca-Pereira+S%22">Roca-Pereira S</searchLink>; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain.<br /><searchLink fieldCode="AU" term="%22Vinyals+A%22">Vinyals A</searchLink>; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain.<br /><searchLink fieldCode="AU" term="%22Mato-Blanco+X%22">Mato-Blanco X</searchLink>; Neurogenomics Group, Hospital del Mar Research Institute, Parc de Recerca Biomèdica de Barcelona (PRBB), Dr. Aiguader, 88, Barcelona, Catalonia, 08003, Spain.<br /><searchLink fieldCode="AU" term="%22Vela-Martínez+M%22">Vela-Martínez M</searchLink>; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain.<br /><searchLink fieldCode="AU" term="%22Dakterzada+F%22">Dakterzada F</searchLink>; Cognition and Behaviour Study Group - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain.<br /><searchLink fieldCode="AU" term="%22Romero+L%22">Romero L</searchLink>; Cognition and Behaviour Study Group - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain.<br /><searchLink fieldCode="AU" term="%22Santamaría+E%22">Santamaría E</searchLink>; Proteomics Unit, Clinical Neuroproteomics Laboratory, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA)., Pamplona, Navarra, 31008, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Irigoyen+J%22">Fernández-Irigoyen J</searchLink>; Proteomics Unit, Clinical Neuroproteomics Laboratory, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA)., Pamplona, Navarra, 31008, Spain.<br /><searchLink fieldCode="AU" term="%22Ferrer+I%22">Ferrer I</searchLink>; Department of Pathology and Experimental Therapeutics - Bellvitge Faculty, University of Barcelona, L'Hospitalet de Llobregat, Barcelona, 08907, Spain.<br /><searchLink fieldCode="AU" term="%22Povedano+M%22">Povedano M</searchLink>; Neurology and Neurogenetics Group - Neuroscience Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Functional Unit of Amyotrophic Lateral Sclerosis (UFELA), Service of Neurology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, 08907, Spain.<br /><searchLink fieldCode="AU" term="%22Del+Rio+JA%22">Del Rio JA</searchLink>; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Science Park of Barcelona, Barcelona, 08028, Spain; Institute of Neurosciences, University of Barcelona, Barcelona, Spain; Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain.<br /><searchLink fieldCode="AU" term="%22Santpere+G%22">Santpere G</searchLink>; Neurogenomics Group, Hospital del Mar Research Institute, Parc de Recerca Biomèdica de Barcelona (PRBB), Dr. Aiguader, 88, Barcelona, Catalonia, 08003, Spain.<br /><searchLink fieldCode="AU" term="%22Portero-Otín+M%22">Portero-Otín M</searchLink>; Metabolic Pathophysiology Research Group, Department of Experimental Medicine, University of Lleida - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain.<br /><searchLink fieldCode="AU" term="%22Piñol-Ripoll+G%22">Piñol-Ripoll G</searchLink>; Cognition and Behaviour Study Group - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain. Electronic address: gerard_437302@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Andrés-Benito+P%22">Andrés-Benito P</searchLink>; Network Centre of Biomedical Research of Neurodegenerative Diseases (CIBERNED), Institute of Health Carlos III, L'Hospitalet de Llobregat, Barcelona, 08907, Spain; Cognition and Behaviour Study Group - Institute for Research in Biomedicine of Lleida (IRBLleida), Lleida, 25196, Spain; Molecular and Cellular Neurobiotechnology, Institute for Bioengineering of Catalonia (IBEC), Barcelona Institute of Science and Technology (BIST), Science Park of Barcelona, Barcelona, 08028, Spain. Electronic address: pol.andres.benito@gmail.com.
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