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Structural basis for pan-coronavirus inhibition of 3CL protease.

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Title: Structural basis for pan-coronavirus inhibition of 3CL protease.
Authors: Reddem ER; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Forouhar F; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA., Liu C; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA., Stevens SK; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA., Jekle A; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA., Chang CW; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., Oswal N; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA., McGowan DC; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Vandyck K; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Smith DB; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA., Raboisson P; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium., Beigelman LN; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA., Katsamba PS; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Bahna F; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Mannepalli S; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Blatt L; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA., Perlin D; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA; Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ, USA., Symons JA; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA., Shapiro L; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: lss8@columbia.edu., Stoycheva AD; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA. Electronic address: astoycheva@aligos.com.
Source: Structure (London, England : 1993) [Structure] 2026 Apr 02; Vol. 34 (4), pp. 562-571.e8. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural basis for pan-coronavirus inhibition of 3CL protease.
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  Data: <searchLink fieldCode="AU" term="%22Reddem+ER%22">Reddem ER</searchLink>; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Forouhar+F%22">Forouhar F</searchLink>; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY 10032, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Stevens+SK%22">Stevens SK</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Jekle+A%22">Jekle A</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chang+CW%22">Chang CW</searchLink>; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Oswal+N%22">Oswal N</searchLink>; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22McGowan+DC%22">McGowan DC</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vandyck+K%22">Vandyck K</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Smith+DB%22">Smith DB</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Raboisson+P%22">Raboisson P</searchLink>; Aligos Belgium BV, Gaston Geenslaan 1, 3001 Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Beigelman+LN%22">Beigelman LN</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Katsamba+PS%22">Katsamba PS</searchLink>; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Bahna+F%22">Bahna F</searchLink>; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Mannepalli+S%22">Mannepalli S</searchLink>; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Blatt+L%22">Blatt L</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Perlin+D%22">Perlin D</searchLink>; Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA; Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ, USA.<br /><searchLink fieldCode="AU" term="%22Symons+JA%22">Symons JA</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Shapiro+L%22">Shapiro L</searchLink>; Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA; Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA. Electronic address: lss8@columbia.edu.<br /><searchLink fieldCode="AU" term="%22Stoycheva+AD%22">Stoycheva AD</searchLink>; Aligos Therapeutics, Inc., 1 Corporate Drive, 2nd Floor, South San Francisco, CA 94080, USA. Electronic address: astoycheva@aligos.com.
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  Data: <searchLink fieldCode="JN" term="%22101087697%22">Structure (London, England : 1993)</searchLink> [Structure] 2026 Apr 02; Vol. 34 (4), pp. 562-571.e8. <i>Date of Electronic Publication: </i>2026 Feb 05.
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