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ApoE-directed CpG nano-immunoadjuvant ameliorates Alzheimer's-like pathology in mice.

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Title: ApoE-directed CpG nano-immunoadjuvant ameliorates Alzheimer's-like pathology in mice.
Authors: Huang X; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China., Sun YY; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China., Qin YR; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou 215004, China., Chen H; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China., Pan TT; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China., Zhao SS; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China., Cai Q; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China., Zhang XS; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China., Nie XD; Department of Neurosurgery, the First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China., Feng L; Monash Suzhou Research Institute, Monash University, Suzhou, Jiangsu 215000, China., Hu H; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China., Tang Y; International Collaborative Centre on Big Science Plan for Purinergic Signaling, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China., Zhang PZ; Suzhou GenePharma Co., Ltd., Suzhou, Jiangsu 215123, China., Zhong ZY; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China., Li J; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China. Electronic address: lijie@suda.edu.cn., Lu L; Key Laboratory of Cellular Physiology, Ministry of Education and School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030001, China. Electronic address: luli@sxmu.edu.cn., Meng FH; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address: fhmeng@suda.edu.cn., Ma QH; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China. Electronic address: maquanhong@suda.edu.cn.
Source: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2026 Apr 10; Vol. 392, pp. 114687. Date of Electronic Publication: 2026 Feb 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 8607908 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4995 (Electronic) Linking ISSN: 01683659 NLM ISO Abbreviation: J Control Release Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ApoE-directed CpG nano-immunoadjuvant ameliorates Alzheimer's-like pathology in mice.
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  Data: <searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China.<br /><searchLink fieldCode="AU" term="%22Sun+YY%22">Sun YY</searchLink>; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China.<br /><searchLink fieldCode="AU" term="%22Qin+YR%22">Qin YR</searchLink>; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology, the First Affiliated Hospital of Soochow University, Suzhou 215004, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China.<br /><searchLink fieldCode="AU" term="%22Pan+TT%22">Pan TT</searchLink>; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China.<br /><searchLink fieldCode="AU" term="%22Zhao+SS%22">Zhao SS</searchLink>; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China.<br /><searchLink fieldCode="AU" term="%22Cai+Q%22">Cai Q</searchLink>; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China.<br /><searchLink fieldCode="AU" term="%22Zhang+XS%22">Zhang XS</searchLink>; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China.<br /><searchLink fieldCode="AU" term="%22Nie+XD%22">Nie XD</searchLink>; Department of Neurosurgery, the First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.<br /><searchLink fieldCode="AU" term="%22Feng+L%22">Feng L</searchLink>; Monash Suzhou Research Institute, Monash University, Suzhou, Jiangsu 215000, China.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.<br /><searchLink fieldCode="AU" term="%22Tang+Y%22">Tang Y</searchLink>; International Collaborative Centre on Big Science Plan for Purinergic Signaling, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.<br /><searchLink fieldCode="AU" term="%22Zhang+PZ%22">Zhang PZ</searchLink>; Suzhou GenePharma Co., Ltd., Suzhou, Jiangsu 215123, China.<br /><searchLink fieldCode="AU" term="%22Zhong+ZY%22">Zhong ZY</searchLink>; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China.<br /><searchLink fieldCode="AU" term="%22Li+J%22">Li J</searchLink>; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China. Electronic address: lijie@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Lu+L%22">Lu L</searchLink>; Key Laboratory of Cellular Physiology, Ministry of Education and School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030001, China. Electronic address: luli@sxmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Meng+FH%22">Meng FH</searchLink>; Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, State Key Laboratory of Radiation Medicine and Protection, and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China. Electronic address: fhmeng@suda.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ma+QH%22">Ma QH</searchLink>; Department of General Practice, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu 215123, China; Department of Neurology and Clinical Research Center of Neurological Disease, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China; MOE Key Laboratory of Geriatric Diseases and Immunology, Soochow University, Suzhou, Jiangsu 215004, China. Electronic address: maquanhong@suda.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%228607908%22">Journal of controlled release : official journal of the Controlled Release Society</searchLink> [J Control Release] 2026 Apr 10; Vol. 392, pp. 114687. <i>Date of Electronic Publication: </i>2026 Feb 04.
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