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Pulsed field ablation versus conventional thermal ablation for paroxysmal atrial fibrillation: 4-year outcomes in the ADVENT-LTO study.

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Title: Pulsed field ablation versus conventional thermal ablation for paroxysmal atrial fibrillation: 4-year outcomes in the ADVENT-LTO study.
Authors: Reddy VY; Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, New York, NY, USA. vivek.reddy@mountsinai.org., Gerstenfeld EP; University of California, San Francisco, San Francisco, CA, USA., Mountantonakis SE; Lenox Hill Hospital, Northwell Cardiovascular Institute, New York, NY, USA., Patel C; University of Pittsburgh Medical Center Pinnacle, Harrisburg, PA, USA., Ellenbogen KA; Virginia Commonwealth University, Richmond, VA, USA., Harding JD; Doylestown Hospital, Doylestown, PA, USA., Gibson DN; Scripps Clinic and Prebys Cardiovascular Institute, San Diego, CA, USA., Natale A; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, TX, USA.; Department of Biomedicine and Prevention, Division of Cardiology, University of Tor Vergata, Rome, Italy., Waks JW; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Calkins H; Johns Hopkins Hospital, Baltimore, MD, USA., Gupta SK; Saint Luke's Mid-America Heart Institute, Kansas City, MO, USA., Woods CE; Sutter California Pacific Medical Center, San Francisco, CA, USA., Whang W; Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, New York, NY, USA., Daccarett M; St. Luke's Medical Center, Boise, ID, USA., Cuoco FA; Charleston Heart Specialists, Trident Medical Center, Charleston, SC, USA., Delurgio DB; Emory University Hospital, Atlanta, GA, USA., Richards E; Boston Scientific Corporation, St. Paul, MN, USA., Martens MD; Boston Scientific Corporation, St. Paul, MN, USA., Sutton B; Boston Scientific Corporation, St. Paul, MN, USA., Mansour M; Heart and Vascular Institute, Mass General Brigham, Boston, MA, USA.
Corporate Authors: ADVENT-LTO Study Investigators
Source: Nature medicine [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1444-1453. Date of Electronic Publication: 2026 Feb 06.
Publication Type: Comparative Study; Journal Article; Multicenter Study; Observational Study; Randomized Controlled Trial
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Pulsed field ablation versus conventional thermal ablation for paroxysmal atrial fibrillation: 4-year outcomes in the ADVENT-LTO study.
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  Data: <searchLink fieldCode="AU" term="%22Reddy+VY%22">Reddy VY</searchLink>; Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, New York, NY, USA. vivek.reddy@mountsinai.org.<br /><searchLink fieldCode="AU" term="%22Gerstenfeld+EP%22">Gerstenfeld EP</searchLink>; University of California, San Francisco, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Mountantonakis+SE%22">Mountantonakis SE</searchLink>; Lenox Hill Hospital, Northwell Cardiovascular Institute, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Patel+C%22">Patel C</searchLink>; University of Pittsburgh Medical Center Pinnacle, Harrisburg, PA, USA.<br /><searchLink fieldCode="AU" term="%22Ellenbogen+KA%22">Ellenbogen KA</searchLink>; Virginia Commonwealth University, Richmond, VA, USA.<br /><searchLink fieldCode="AU" term="%22Harding+JD%22">Harding JD</searchLink>; Doylestown Hospital, Doylestown, PA, USA.<br /><searchLink fieldCode="AU" term="%22Gibson+DN%22">Gibson DN</searchLink>; Scripps Clinic and Prebys Cardiovascular Institute, San Diego, CA, USA.<br /><searchLink fieldCode="AU" term="%22Natale+A%22">Natale A</searchLink>; Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, TX, USA.; Department of Biomedicine and Prevention, Division of Cardiology, University of Tor Vergata, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Waks+JW%22">Waks JW</searchLink>; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Calkins+H%22">Calkins H</searchLink>; Johns Hopkins Hospital, Baltimore, MD, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+SK%22">Gupta SK</searchLink>; Saint Luke's Mid-America Heart Institute, Kansas City, MO, USA.<br /><searchLink fieldCode="AU" term="%22Woods+CE%22">Woods CE</searchLink>; Sutter California Pacific Medical Center, San Francisco, CA, USA.<br /><searchLink fieldCode="AU" term="%22Whang+W%22">Whang W</searchLink>; Helmsley Electrophysiology Center, Mount Sinai Fuster Heart Hospital, New York, NY, USA.<br /><searchLink fieldCode="AU" term="%22Daccarett+M%22">Daccarett M</searchLink>; St. Luke's Medical Center, Boise, ID, USA.<br /><searchLink fieldCode="AU" term="%22Cuoco+FA%22">Cuoco FA</searchLink>; Charleston Heart Specialists, Trident Medical Center, Charleston, SC, USA.<br /><searchLink fieldCode="AU" term="%22Delurgio+DB%22">Delurgio DB</searchLink>; Emory University Hospital, Atlanta, GA, USA.<br /><searchLink fieldCode="AU" term="%22Richards+E%22">Richards E</searchLink>; Boston Scientific Corporation, St. Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Martens+MD%22">Martens MD</searchLink>; Boston Scientific Corporation, St. Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Sutton+B%22">Sutton B</searchLink>; Boston Scientific Corporation, St. Paul, MN, USA.<br /><searchLink fieldCode="AU" term="%22Mansour+M%22">Mansour M</searchLink>; Heart and Vascular Institute, Mass General Brigham, Boston, MA, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 Apr; Vol. 32 (4), pp. 1444-1453. <i>Date of Electronic Publication: </i>2026 Feb 06.
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