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USP30 senses serine/glycine levels to regulate serine biosynthesis and colorectal tumorigenesis by deubiquitinating FTO.

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Title: USP30 senses serine/glycine levels to regulate serine biosynthesis and colorectal tumorigenesis by deubiquitinating FTO.
Authors: Qiao Y; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.; Department of Colorectal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China., Wang C; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China., Liu H; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China., Sun H; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China., Zhao H; School of Integrative Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, China., Zhang Q; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China., Dai X; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China., Sun M; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China., Wang T; Cardiothoracic Surgery Department, Characteristic Medical Center of the Chinese People's Armed Police Force, Tianjin, China., He T; Department of Pathology, Characteristic Medical Center of The Chinese People's Armed Police Force, Tianjin, China., Li Z; Guangzhou key laboratory for clinical rapid diagnosis and early warning of infectious diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China., Li Y; Department of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, China., Xue J; Tumor Research Institute, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China., Zhang C; Tumor Research Institute, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China. chunze.zhang@nankai.edu.cn.; Department of Colorectal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China. chunze.zhang@nankai.edu.cn., Shan C; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China. changliangshan@nankai.edu.cn., Zhang S; School of Integrative Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, China. shuaizhang@tjutcm.edu.cn.
Source: Cell death and differentiation [Cell Death Differ] 2026 Feb 06. Date of Electronic Publication: 2026 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: USP30 senses serine/glycine levels to regulate serine biosynthesis and colorectal tumorigenesis by deubiquitinating FTO.
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  Data: <searchLink fieldCode="AU" term="%22Qiao+Y%22">Qiao Y</searchLink>; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.; Department of Colorectal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Sun+H%22">Sun H</searchLink>; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; School of Integrative Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Dai+X%22">Dai X</searchLink>; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Sun+M%22">Sun M</searchLink>; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; Cardiothoracic Surgery Department, Characteristic Medical Center of the Chinese People's Armed Police Force, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22He+T%22">He T</searchLink>; Department of Pathology, Characteristic Medical Center of The Chinese People's Armed Police Force, Tianjin, China.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Guangzhou key laboratory for clinical rapid diagnosis and early warning of infectious diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Department of Pathology and Institute of Precision Medicine, Jining Medical University, Jining, China.<br /><searchLink fieldCode="AU" term="%22Xue+J%22">Xue J</searchLink>; Tumor Research Institute, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China.<br /><searchLink fieldCode="AU" term="%22Zhang+C%22">Zhang C</searchLink>; Tumor Research Institute, The First Affiliated Hospital of Hebei North University, Zhangjiakou, China. chunze.zhang@nankai.edu.cn.; Department of Colorectal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China. chunze.zhang@nankai.edu.cn.<br /><searchLink fieldCode="AU" term="%22Shan+C%22">Shan C</searchLink>; State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China. changliangshan@nankai.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; School of Integrative Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, China. shuaizhang@tjutcm.edu.cn.
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      – TitleFull: USP30 senses serine/glycine levels to regulate serine biosynthesis and colorectal tumorigenesis by deubiquitinating FTO.
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              Text: 2026 Feb 06
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