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Multimodal MRI of episodic cluster headache reveals frontal cortical alterations and network-level connectivity changes.

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Title: Multimodal MRI of episodic cluster headache reveals frontal cortical alterations and network-level connectivity changes.
Authors: Caramia F; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. francesca.caramia@uniroma1.it., Di Renzo A; Diagnostic Department - Neuroradiology - Hospital S. Maria, Terni, Italy. antoniomp777@hotmail.it., Giardina I; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, 00161, Rome, Italy., Chiffi D; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy., Giuliani G; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy., Sebastianelli G; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy., Casillo F; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy., Abagnale C; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy., Conti F; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, 00161, Rome, Italy., Lafavia F; Neuroradiology Unit, Policlinico Umberto I, Rome, Italy., Fiorelli M; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy., Song MM; Laboratory for Brain Science and Neuropsychiatric Diseases, Department of Neurology, Headache Center, Shanxi Provincial, The First Hospital of Shanxi Medical University, Shanxi Medical University, Shanxi, China., Altieri M; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy., Coppola G; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy. gianluca.coppola@uniroma1.it.
Source: The journal of headache and pain [J Headache Pain] 2026 Feb 06; Vol. 27 (1). Date of Electronic Publication: 2026 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 100940562 Publication Model: Electronic Cited Medium: Internet ISSN: 1129-2377 (Electronic) Linking ISSN: 11292369 NLM ISO Abbreviation: J Headache Pain Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Caramia+F%22">Caramia F</searchLink>; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. francesca.caramia@uniroma1.it.<br /><searchLink fieldCode="AU" term="%22Di+Renzo+A%22">Di Renzo A</searchLink>; Diagnostic Department - Neuroradiology - Hospital S. Maria, Terni, Italy. antoniomp777@hotmail.it.<br /><searchLink fieldCode="AU" term="%22Giardina+I%22">Giardina I</searchLink>; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Chiffi+D%22">Chiffi D</searchLink>; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Giuliani+G%22">Giuliani G</searchLink>; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Sebastianelli+G%22">Sebastianelli G</searchLink>; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.<br /><searchLink fieldCode="AU" term="%22Casillo+F%22">Casillo F</searchLink>; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.<br /><searchLink fieldCode="AU" term="%22Abagnale+C%22">Abagnale C</searchLink>; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy.<br /><searchLink fieldCode="AU" term="%22Conti+F%22">Conti F</searchLink>; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.; Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, 00161, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lafavia+F%22">Lafavia F</searchLink>; Neuroradiology Unit, Policlinico Umberto I, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Fiorelli+M%22">Fiorelli M</searchLink>; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Song+MM%22">Song MM</searchLink>; Laboratory for Brain Science and Neuropsychiatric Diseases, Department of Neurology, Headache Center, Shanxi Provincial, The First Hospital of Shanxi Medical University, Shanxi Medical University, Shanxi, China.<br /><searchLink fieldCode="AU" term="%22Altieri+M%22">Altieri M</searchLink>; Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Coppola+G%22">Coppola G</searchLink>; Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino ICOT, Latina, Italy. gianluca.coppola@uniroma1.it.
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