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Ochratoxin A drives hepatocellular carcinoma progression via GRPR-mediated activation of PLCβ/IP3R/Ca²⁺ and RPS15A/p53 pathways by regulating cancer cell fate.

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Title: Ochratoxin A drives hepatocellular carcinoma progression via GRPR-mediated activation of PLCβ/IP3R/Ca²⁺ and RPS15A/p53 pathways by regulating cancer cell fate.
Authors: Yang YQ; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Li WX; Department of Neurosurgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Zhao XL; School of Public Health, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712046, China., Yang Y; Department of General Surgery, 521 Hospital of Norinco Group, Xi'an, Shaanxi 710000, China., Liu ZG; Department of Thoracic Surgery, Tumor Hospital of Shaanxi Province, Affiliated to the Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Cheng SL; Basic Medical Experiment Teaching Center, School of Basic Medical Sciences, Xi'an, Shaanxi 710061, China., Zhou K; Department of SURGICAL Oncology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Diao DM; Department of SURGICAL Oncology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Ge P; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Lv MQ; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Sun Y; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Kang JY; School of Public Health, Capital Medical University, Beijing 100069, China., Sun RF; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: ruifang_sun@xjtu.edu.cn., Zhou DX; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: zdxtougao@163.com., Gao JH; Toxicology Research Center, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi 710065, China. Electronic address: gaoxing2285@126.com.
Source: Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2026 Jan 15; Vol. 310, pp. 119821. Date of Electronic Publication: 2026 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE
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  Data: Ochratoxin A drives hepatocellular carcinoma progression via GRPR-mediated activation of PLCβ/IP3R/Ca²⁺ and RPS15A/p53 pathways by regulating cancer cell fate.
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  Data: <searchLink fieldCode="AU" term="%22Yang+YQ%22">Yang YQ</searchLink>; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.<br /><searchLink fieldCode="AU" term="%22Li+WX%22">Li WX</searchLink>; Department of Neurosurgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.<br /><searchLink fieldCode="AU" term="%22Zhao+XL%22">Zhao XL</searchLink>; School of Public Health, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712046, China.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of General Surgery, 521 Hospital of Norinco Group, Xi'an, Shaanxi 710000, China.<br /><searchLink fieldCode="AU" term="%22Liu+ZG%22">Liu ZG</searchLink>; Department of Thoracic Surgery, Tumor Hospital of Shaanxi Province, Affiliated to the Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.<br /><searchLink fieldCode="AU" term="%22Cheng+SL%22">Cheng SL</searchLink>; Basic Medical Experiment Teaching Center, School of Basic Medical Sciences, Xi'an, Shaanxi 710061, China.<br /><searchLink fieldCode="AU" term="%22Zhou+K%22">Zhou K</searchLink>; Department of SURGICAL Oncology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.<br /><searchLink fieldCode="AU" term="%22Diao+DM%22">Diao DM</searchLink>; Department of SURGICAL Oncology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.<br /><searchLink fieldCode="AU" term="%22Ge+P%22">Ge P</searchLink>; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.<br /><searchLink fieldCode="AU" term="%22Lv+MQ%22">Lv MQ</searchLink>; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.<br /><searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.<br /><searchLink fieldCode="AU" term="%22Kang+JY%22">Kang JY</searchLink>; School of Public Health, Capital Medical University, Beijing 100069, China.<br /><searchLink fieldCode="AU" term="%22Sun+RF%22">Sun RF</searchLink>; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: ruifang_sun@xjtu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zhou+DX%22">Zhou DX</searchLink>; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: zdxtougao@163.com.<br /><searchLink fieldCode="AU" term="%22Gao+JH%22">Gao JH</searchLink>; Toxicology Research Center, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi 710065, China. Electronic address: gaoxing2285@126.com.
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        Value: 10.1016/j.ecoenv.2026.119821
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        Text: English
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              Text: 2026 Jan 15
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