Ochratoxin A drives hepatocellular carcinoma progression via GRPR-mediated activation of PLCβ/IP3R/Ca²⁺ and RPS15A/p53 pathways by regulating cancer cell fate.
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| Title: | Ochratoxin A drives hepatocellular carcinoma progression via GRPR-mediated activation of PLCβ/IP3R/Ca²⁺ and RPS15A/p53 pathways by regulating cancer cell fate. |
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| Authors: | Yang YQ; Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Li WX; Department of Neurosurgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Zhao XL; School of Public Health, Shaanxi University of Chinese Medicine, Xi'an, Shaanxi 712046, China., Yang Y; Department of General Surgery, 521 Hospital of Norinco Group, Xi'an, Shaanxi 710000, China., Liu ZG; Department of Thoracic Surgery, Tumor Hospital of Shaanxi Province, Affiliated to the Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Cheng SL; Basic Medical Experiment Teaching Center, School of Basic Medical Sciences, Xi'an, Shaanxi 710061, China., Zhou K; Department of SURGICAL Oncology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Diao DM; Department of SURGICAL Oncology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Ge P; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Lv MQ; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Sun Y; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China., Kang JY; School of Public Health, Capital Medical University, Beijing 100069, China., Sun RF; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: ruifang_sun@xjtu.edu.cn., Zhou DX; Department of Pathology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Institute of Genetics and Developmental Biology, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: zdxtougao@163.com., Gao JH; Toxicology Research Center, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi 710065, China. Electronic address: gaoxing2285@126.com. |
| Source: | Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2026 Jan 15; Vol. 310, pp. 119821. Date of Electronic Publication: 2026 Feb 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7805381 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2414 (Electronic) Linking ISSN: 01476513 NLM ISO Abbreviation: Ecotoxicol Environ Saf Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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