Enduring improvements in hepatic insulin sensitivity predict sustained remission of prediabetes during a 3-year lifestyle intervention: results from the PREVIEW multinational diabetes prevention trial.

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Title: Enduring improvements in hepatic insulin sensitivity predict sustained remission of prediabetes during a 3-year lifestyle intervention: results from the PREVIEW multinational diabetes prevention trial.
Authors: Zhu R; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China., Guo J; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China., Huttunen-Lenz M; Institute for Nursing Science, University of Education Schwäbisch Gmünd, Germany., Stratton G; Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea, UK., Swindell N; Applied Sports, Technology, Exercise and Medicine (A-STEM) Research Centre, Swansea University, Swansea, UK., Macdonald IA; Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, Queen's Medical Centre, Nottingham, UK., Handjieva-Darlenska T; Department of Pharmacology and Toxicology, Medical University of Sofia, Sofia, Bulgaria., Handjiev S; Department of Pharmacology and Toxicology, Medical University of Sofia, Sofia, Bulgaria., Navas-Carretero S; Centre for Nutrition Research, University of Navarra, Pamplona, Spain; Centro de Investigacion Biomedica en Red Area de Fisiologia de la Obesidad y la Nutricion (CIBEROBN), Madrid, Spain; IdisNA Instituto for Health Research, Pamplona, Spain., Poppitt SD; Human Nutrition Unit, School of Biological Sciences, Department of Medicine, University of Auckland, New Zealand., Silvestre M; CINTESIS, NOVA Medical School, NOVA University of Lisbon, Lisbon, Portugal., Schlicht W; Department of Exercise and Health Sciences, University of Stuttgart, 70569, Stuttgart, Germany., Fogelholm M; Department of Food and Nutrition, University of Helsinki, Helsinki, Finland., Martinez JA; Centro de Investigacion Biomedica en Red Area de Fisiologia de la Obesidad y la Nutricion (CIBEROBN), Madrid, Spain; Precision Nutrition and Cardiometabolic Health Program, IMDEA-Nutrition Institute (Madrid Institute for Advanced Studies), CEI UAM + CSIC, Madrid, Spain; Department of Medicine and Endocrinology, University of Valladolid, Valladolid, Spain., Raben A; Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Brand-Miller J; School of Life and Environmental Sciences and Charles Perkins Centre, the University of Sydney, Sydney, Australia. Electronic address: jennie.brandmiller@sydney.edu.au.
Source: Metabolism: clinical and experimental [Metabolism] 2026 May; Vol. 178, pp. 156546. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1532-8600
DOI:10.1016/j.metabol.2026.156546