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Early intervention versus treatment as usual for adolescents with first-episode psychosis: Protocol for the randomized OPUS YOUNG trial.

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Title: Early intervention versus treatment as usual for adolescents with first-episode psychosis: Protocol for the randomized OPUS YOUNG trial.
Authors: Madsen MS; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Section for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. Electronic address: mathilde.soendergaard.madsen@regionh.dk., Melau M; Mental Health Center Copenhagen, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark., Andersen NK; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nielsen CF; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Larsen N; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Andersen TL; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nordentoft M; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Mental Health Center Copenhagen, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark., Jepsen JRM; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark., Thorup AAE; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jeppesen P; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Child and Adolescent Psychiatry, Copenhagen University Hospital - Psychiatry Region Zealand, Denmark., Fagerlund B; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark., Rimvall MK; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Child and Adolescent Psychiatry, Copenhagen University Hospital - Psychiatry Region Zealand, Denmark., McGorry P; Orygen: The National Centre of Excellence in Youth Mental Health, Australia; Centre for Youth Mental Health, University of Melbourne, Australia., Singh S; Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom; Coventry & Warwickshire Partnership NHS Trust, Coventry, United Kingdom., Vernal DL; Psychiatry, Aalborg University Hospital, North Denmark Region, Denmark; Department of Clinical Medicine, Aalborg University, North Denmark Region, Denmark., Hastrup LH; Psychiatric Research Unit, Psychiatry in Region Zealand, Slagelse, Denmark; Danish Centre for Health Economics (DaCHE), University of Southern Denmark, Odense, Denmark., Olsen LR; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark., Rydkjær J; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark., Correll CU; Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany., Christensen R; Section for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Denmark., Pagsberg AK; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Source: Contemporary clinical trials [Contemp Clin Trials] 2026 Mar; Vol. 162, pp. 108253. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article; Clinical Trial Protocol
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101242342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2030 (Electronic) Linking ISSN: 15517144 NLM ISO Abbreviation: Contemp Clin Trials Subsets: MEDLINE
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  Data: Early intervention versus treatment as usual for adolescents with first-episode psychosis: Protocol for the randomized OPUS YOUNG trial.
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  Data: <searchLink fieldCode="AU" term="%22Madsen+MS%22">Madsen MS</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Section for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. Electronic address: mathilde.soendergaard.madsen@regionh.dk.<br /><searchLink fieldCode="AU" term="%22Melau+M%22">Melau M</searchLink>; Mental Health Center Copenhagen, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+NK%22">Andersen NK</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nielsen+CF%22">Nielsen CF</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Larsen+N%22">Larsen N</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Andersen+TL%22">Andersen TL</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Nordentoft+M%22">Nordentoft M</searchLink>; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Mental Health Center Copenhagen, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jepsen+JRM%22">Jepsen JRM</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Thorup+AAE%22">Thorup AAE</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Jeppesen+P%22">Jeppesen P</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Child and Adolescent Psychiatry, Copenhagen University Hospital - Psychiatry Region Zealand, Denmark.<br /><searchLink fieldCode="AU" term="%22Fagerlund+B%22">Fagerlund B</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rimvall+MK%22">Rimvall MK</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Department of Child and Adolescent Psychiatry, Copenhagen University Hospital - Psychiatry Region Zealand, Denmark.<br /><searchLink fieldCode="AU" term="%22McGorry+P%22">McGorry P</searchLink>; Orygen: The National Centre of Excellence in Youth Mental Health, Australia; Centre for Youth Mental Health, University of Melbourne, Australia.<br /><searchLink fieldCode="AU" term="%22Singh+S%22">Singh S</searchLink>; Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom; Coventry & Warwickshire Partnership NHS Trust, Coventry, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Vernal+DL%22">Vernal DL</searchLink>; Psychiatry, Aalborg University Hospital, North Denmark Region, Denmark; Department of Clinical Medicine, Aalborg University, North Denmark Region, Denmark.<br /><searchLink fieldCode="AU" term="%22Hastrup+LH%22">Hastrup LH</searchLink>; Psychiatric Research Unit, Psychiatry in Region Zealand, Slagelse, Denmark; Danish Centre for Health Economics (DaCHE), University of Southern Denmark, Odense, Denmark.<br /><searchLink fieldCode="AU" term="%22Olsen+LR%22">Olsen LR</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Rydkjær+J%22">Rydkjær J</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.<br /><searchLink fieldCode="AU" term="%22Correll+CU%22">Correll CU</searchLink>; Department of Psychiatry, The Zucker Hillside Hospital, Northwell Health, Glen Oaks, NY, USA; Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Christensen+R%22">Christensen R</searchLink>; Section for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Research Unit of Rheumatology, Department of Clinical Research, University of Southern Denmark, Odense University Hospital, Denmark.<br /><searchLink fieldCode="AU" term="%22Pagsberg+AK%22">Pagsberg AK</searchLink>; Child and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark; Dept of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
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  Data: <searchLink fieldCode="JN" term="%22101242342%22">Contemporary clinical trials</searchLink> [Contemp Clin Trials] 2026 Mar; Vol. 162, pp. 108253. <i>Date of Electronic Publication: </i>2026 Feb 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101242342 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1559-2030 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215517144%22">15517144 </searchLink><i>NLM ISO Abbreviation: </i>Contemp Clin Trials <i>Subsets: </i>MEDLINE
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