View in EDS

The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.

Saved in:
Bibliographic Details
Title: The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.
Authors: Michail C; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France., Berthelet J; Université Paris Cité, CNRS, Centre Epigénétique et Destin Cellulaire, Paris, France., Mechaly AE; Institut Pasteur, CNRS, Plate-forme de Cristallographie-C2RT, Paris, France., Bui LC; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France., Yang H; Department of Lymphoma and Myeloma, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Cai D; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France., Al Mahi A; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France., Xie A; Marine Biomedical Institute of Qingdao, School of Pharmacy and Medicine, Ocean University of China, Qingdao, Shandong, China., Bisio V; Université Paris Cité, INSERM, Institut de Recherche Saint Louis, Paris, France., Sirri V; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France., Dupret JM; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France., Guidez F; Université de Bourgogne, INSERM, Dijon, France., Xu X; Marine Biomedical Institute of Qingdao, School of Pharmacy and Medicine, Ocean University of China, Qingdao, Shandong, China., Joly N; Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France., Regad L; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France; Université Paris Cité, CNRS, INSERM, Unité de Biologie Fonctionnelle et Adaptative, Paris, France., Viguier M; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France., Deshayes F; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France., Dulphy N; Université Paris Cité, INSERM, Institut de Recherche Saint Louis, Paris, France., Green MR; Department of Lymphoma and Myeloma, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Haouz A; Institut Pasteur, CNRS, Plate-forme de Cristallographie-C2RT, Paris, France., Rodrigues Lima F; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France. Electronic address: fernando.rodrigues-lima@u-paris.fr.
Source: The Journal of biological chemistry [J Biol Chem] 2026 Mar; Vol. 302 (3), pp. 111259. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41654133
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Michail+C%22">Michail C</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.<br /><searchLink fieldCode="AU" term="%22Berthelet+J%22">Berthelet J</searchLink>; Université Paris Cité, CNRS, Centre Epigénétique et Destin Cellulaire, Paris, France.<br /><searchLink fieldCode="AU" term="%22Mechaly+AE%22">Mechaly AE</searchLink>; Institut Pasteur, CNRS, Plate-forme de Cristallographie-C2RT, Paris, France.<br /><searchLink fieldCode="AU" term="%22Bui+LC%22">Bui LC</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.<br /><searchLink fieldCode="AU" term="%22Yang+H%22">Yang H</searchLink>; Department of Lymphoma and Myeloma, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Cai+D%22">Cai D</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.<br /><searchLink fieldCode="AU" term="%22Al+Mahi+A%22">Al Mahi A</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.<br /><searchLink fieldCode="AU" term="%22Xie+A%22">Xie A</searchLink>; Marine Biomedical Institute of Qingdao, School of Pharmacy and Medicine, Ocean University of China, Qingdao, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Bisio+V%22">Bisio V</searchLink>; Université Paris Cité, INSERM, Institut de Recherche Saint Louis, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sirri+V%22">Sirri V</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dupret+JM%22">Dupret JM</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.<br /><searchLink fieldCode="AU" term="%22Guidez+F%22">Guidez F</searchLink>; Université de Bourgogne, INSERM, Dijon, France.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Marine Biomedical Institute of Qingdao, School of Pharmacy and Medicine, Ocean University of China, Qingdao, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Joly+N%22">Joly N</searchLink>; Université Paris Cité, CNRS, Institut Jacques Monod, Paris, France.<br /><searchLink fieldCode="AU" term="%22Regad+L%22">Regad L</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France; Université Paris Cité, CNRS, INSERM, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.<br /><searchLink fieldCode="AU" term="%22Viguier+M%22">Viguier M</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.<br /><searchLink fieldCode="AU" term="%22Deshayes+F%22">Deshayes F</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dulphy+N%22">Dulphy N</searchLink>; Université Paris Cité, INSERM, Institut de Recherche Saint Louis, Paris, France.<br /><searchLink fieldCode="AU" term="%22Green+MR%22">Green MR</searchLink>; Department of Lymphoma and Myeloma, Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.<br /><searchLink fieldCode="AU" term="%22Haouz+A%22">Haouz A</searchLink>; Institut Pasteur, CNRS, Plate-forme de Cristallographie-C2RT, Paris, France.<br /><searchLink fieldCode="AU" term="%22Rodrigues+Lima+F%22">Rodrigues Lima F</searchLink>; Université Paris Cité, CNRS, Unité de Biologie Fonctionnelle et Adaptative, Paris, France. Electronic address: fernando.rodrigues-lima@u-paris.fr.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%222985121R%22">The Journal of biological chemistry</searchLink> [J Biol Chem] 2026 Mar; Vol. 302 (3), pp. 111259. <i>Date of Electronic Publication: </i>2026 Feb 05.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Inc%2E+on+behalf+of+American+Society+for+Biochemistry+and+Molecular+Biology%22">Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>2985121R <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1083-351X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200219258%22">00219258 </searchLink><i>NLM ISO Abbreviation: </i>J Biol Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41654133
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.jbc.2026.111259
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 111259
    Titles:
      – TitleFull: The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Michail C
      – PersonEntity:
          Name:
            NameFull: Berthelet J
      – PersonEntity:
          Name:
            NameFull: Mechaly AE
      – PersonEntity:
          Name:
            NameFull: Bui LC
      – PersonEntity:
          Name:
            NameFull: Yang H
      – PersonEntity:
          Name:
            NameFull: Cai D
      – PersonEntity:
          Name:
            NameFull: Al Mahi A
      – PersonEntity:
          Name:
            NameFull: Xie A
      – PersonEntity:
          Name:
            NameFull: Bisio V
      – PersonEntity:
          Name:
            NameFull: Sirri V
      – PersonEntity:
          Name:
            NameFull: Dupret JM
      – PersonEntity:
          Name:
            NameFull: Guidez F
      – PersonEntity:
          Name:
            NameFull: Xu X
      – PersonEntity:
          Name:
            NameFull: Joly N
      – PersonEntity:
          Name:
            NameFull: Regad L
      – PersonEntity:
          Name:
            NameFull: Viguier M
      – PersonEntity:
          Name:
            NameFull: Deshayes F
      – PersonEntity:
          Name:
            NameFull: Dulphy N
      – PersonEntity:
          Name:
            NameFull: Green MR
      – PersonEntity:
          Name:
            NameFull: Haouz A
      – PersonEntity:
          Name:
            NameFull: Rodrigues Lima F
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: 2026 Mar
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1083-351X
          Numbering:
            – Type: volume
              Value: 302
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: The Journal of biological chemistry
              Type: main
ResultId 1