The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation. - Michail C; Berthelet J; Mechaly AE; Bui LC; Yang H; Cai D; Al Mahi A; Xie A; Bisio V; Sirri V; Dupret JM; Guidez F; et al. (The Journal of biological chemistry, 2026)