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Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease.

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Title: Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease.
Authors: Fondevila MF; Department of Medicine, University of California San Diego, La Jolla, California, USA., Kreimeyer H; Department of Medicine, University of California San Diego, La Jolla, California, USA., Hsu CL; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, California, USA., Tamargo-Azpilicueta J; Institute for Chemical Research (IIQ), Scientific Research Center Isla de la Cartuja (cicCartuja), University of Seville - CSIC, Seville, Spain., Day LZ; Biological Sciences and Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Gritsenko M; Biological Sciences and Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Attah K; Biological Sciences and Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Cabré N; Department of Medicine, University of California San Diego, La Jolla, California, USA., Harberts A; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Germany., Tonetti FR; Department of Medicine, University of California San Diego, La Jolla, California, USA., Yang Y; Department of Medicine, University of California San Diego, La Jolla, California, USA., Yamazaki T; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan., Schöler D; Department of Medicine, University of California San Diego, La Jolla, California, USA., Eguileor A; Department of Medicine, University of California San Diego, La Jolla, California, USA., Blasio C; Department of Medicine, University of California San Diego, La Jolla, California, USA., Meijnikman AS; Department of Medicine, University of California San Diego, La Jolla, California, USA; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands., Zhang X; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA., Garcia-Carbonell R; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA., Hook V; Department of Pharmacology, University of California San Diego, La Jolla, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA; Department of Neurosciences, University of California, La Jolla, California, USA., Zhou E; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA., Sun Z; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jacobs JM; Biological Sciences and Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA., Turner JR; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA., Llorente C; Department of Medicine, University of California San Diego, La Jolla, California, USA., AlcHepNet Investigators, Glass CK; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA., Stärkel P; Department of Hepatology and Gastroenterology, St. Luc University Hospital, Catholic University of Louvain, Brussels, Belgium., Reinheckel T; Institute of Molecular Medicine and Cell Research, Medical Faculty and BIOSS Centre for Biological Signaling Studies, Albert-Ludwigs-University Freiburg, Freiburg, Germany., Diaz-Moreno I; Institute for Chemical Research (IIQ), Scientific Research Center Isla de la Cartuja (cicCartuja), University of Seville - CSIC, Seville, Spain., Gonzalez DJ; Department of Pharmacology, University of California San Diego, La Jolla, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA., Schnabl B; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, California, USA. Electronic address: beschnabl@ucsd.edu.
Source: Journal of hepatology [J Hepatol] 2026 Jun; Vol. 84 (6), pp. 1045-1061. Date of Electronic Publication: 2026 Feb 05.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease.
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  Data: <searchLink fieldCode="AU" term="%22Fondevila+MF%22">Fondevila MF</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Kreimeyer+H%22">Kreimeyer H</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Hsu+CL%22">Hsu CL</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, California, USA.<br /><searchLink fieldCode="AU" term="%22Tamargo-Azpilicueta+J%22">Tamargo-Azpilicueta J</searchLink>; Institute for Chemical Research (IIQ), Scientific Research Center Isla de la Cartuja (cicCartuja), University of Seville - CSIC, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Day+LZ%22">Day LZ</searchLink>; Biological Sciences and Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Gritsenko+M%22">Gritsenko M</searchLink>; Biological Sciences and Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Attah+K%22">Attah K</searchLink>; Biological Sciences and Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Cabré+N%22">Cabré N</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Harberts+A%22">Harberts A</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Germany.<br /><searchLink fieldCode="AU" term="%22Tonetti+FR%22">Tonetti FR</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Yang+Y%22">Yang Y</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Yamazaki+T%22">Yamazaki T</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.<br /><searchLink fieldCode="AU" term="%22Schöler+D%22">Schöler D</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Eguileor+A%22">Eguileor A</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Blasio+C%22">Blasio C</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Meijnikman+AS%22">Meijnikman AS</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Division of Biostatistics and Bioinformatics, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA.<br /><searchLink fieldCode="AU" term="%22Garcia-Carbonell+R%22">Garcia-Carbonell R</searchLink>; Department of Molecular and Cellular Biology, The Scripps Research Institute, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Hook+V%22">Hook V</searchLink>; Department of Pharmacology, University of California San Diego, La Jolla, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA; Department of Neurosciences, University of California, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+E%22">Zhou E</searchLink>; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Sun+Z%22">Sun Z</searchLink>; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Jacobs+JM%22">Jacobs JM</searchLink>; Biological Sciences and Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.<br /><searchLink fieldCode="AU" term="%22Turner+JR%22">Turner JR</searchLink>; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.<br /><searchLink fieldCode="AU" term="%22Llorente+C%22">Llorente C</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22AlcHepNet+Investigators%22">AlcHepNet Investigators</searchLink><br /><searchLink fieldCode="AU" term="%22Glass+CK%22">Glass CK</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Stärkel+P%22">Stärkel P</searchLink>; Department of Hepatology and Gastroenterology, St. Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.<br /><searchLink fieldCode="AU" term="%22Reinheckel+T%22">Reinheckel T</searchLink>; Institute of Molecular Medicine and Cell Research, Medical Faculty and BIOSS Centre for Biological Signaling Studies, Albert-Ludwigs-University Freiburg, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Diaz-Moreno+I%22">Diaz-Moreno I</searchLink>; Institute for Chemical Research (IIQ), Scientific Research Center Isla de la Cartuja (cicCartuja), University of Seville - CSIC, Seville, Spain.<br /><searchLink fieldCode="AU" term="%22Gonzalez+DJ%22">Gonzalez DJ</searchLink>; Department of Pharmacology, University of California San Diego, La Jolla, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, California, USA.<br /><searchLink fieldCode="AU" term="%22Schnabl+B%22">Schnabl B</searchLink>; Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, VA San Diego Healthcare System, San Diego, California, USA. Electronic address: beschnabl@ucsd.edu.
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  Data: <searchLink fieldCode="JN" term="%228503886%22">Journal of hepatology</searchLink> [J Hepatol] 2026 Jun; Vol. 84 (6), pp. 1045-1061. <i>Date of Electronic Publication: </i>2026 Feb 05.
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