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Phase I Study Evaluating a Monoclonal Fc-Silenced SARS-CoV-2 Antibody in Patients With Moderate-to-Severe COVID-19.

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Title: Phase I Study Evaluating a Monoclonal Fc-Silenced SARS-CoV-2 Antibody in Patients With Moderate-to-Severe COVID-19.
Authors: Marconato M; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany., Hackenbruch C; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany., Jäger S; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany., Göpel S; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Кirieieva T; Communal Non-Profit Enterprise 'City clinical hospital' of Dnipro city council, Therapy Department, Dnipro State Medical University, Dnipro, Ukraine., Gavrylov A; Municipal Non-Profit Enterprise of Regional Council Regional Clinical Infectious Hospital, Kharkiv, Ukraine., Fricke H; CORAT Therapeutics GmbH, Braunschweig, Germany., Hust M; Department of Medical Biotechnology, Technische Universität Braunschweig, Braunschweig, Germany; Department of Biotechnology, Technische Universität Braunschweig, Braunschweig, Germany., Dübel S; Department of Biotechnology, Technische Universität Braunschweig, Braunschweig, Germany., Dings C; Saarmetrics GmbH, Saarbrücken, Germany., Lehr T; Saarmetrics GmbH, Saarbrücken, Germany; Clinical Pharmacy, Saarland University, Saarbrücken, Germany., Cuevas M; TUD Dresden University of Technology, Faculty of Medicine (and University Hospital), Carl Gustav Carus Department of Otorhinolaryngology Head and Neck Surgery, Dresden, Germany., Bitzer M; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Klein C; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Schwab M; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, University Tuebingen, Tuebingen, Germany; German Cancer Consortium (DKTK), partner site Tuebingen, a partnership between DKFZ and University Hospital Tuebingen, Tuebingen, Germany., Wirtz H; Universitätsklinikum Leipzig Medizinische Klinik II, Leipzig, Germany., Schneider J; Department of Internal Medicine II, TUM University Hospital Rechts der Isar, Technical University of Munich, Munich, Germany., Bitter T; Städtisches Klinikum Braunschweiq qGmbH Med. Klinik VII Klinik für Pneumoloqie und Beatmungsmedizin, Braunschweiq Germany., Frenzel A; CORAT Therapeutics GmbH, Braunschweig, Germany., Dhaen MA; CORAT Therapeutics GmbH, Braunschweig, Germany., Herrmann A; CORAT Therapeutics GmbH, Braunschweig, Germany., Jung G; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany., Walz JS; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tuebingen, a partnership between DKFZ and University Hospital Tuebingen, Tuebingen, Germany., Salih HR; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tuebingen, a partnership between DKFZ and University Hospital Tuebingen, Tuebingen, Germany., Heitmann JS; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany. Electronic address: jonas.heitmann@med.uni-tuebingen.de.
Source: Clinical therapeutics [Clin Ther] 2026 Mar; Vol. 48 (3), pp. 232-239. Date of Electronic Publication: 2026 Feb 07.
Publication Type: Journal Article; Clinical Trial, Phase I; Randomized Controlled Trial; Clinical Trial, Phase II; Multicenter Study
Journal Info: Publisher: Excerpta Medica Country of Publication: United States NLM ID: 7706726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-114X (Electronic) Linking ISSN: 01492918 NLM ISO Abbreviation: Clin Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Phase I Study Evaluating a Monoclonal Fc-Silenced SARS-CoV-2 Antibody in Patients With Moderate-to-Severe COVID-19.
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  Data: <searchLink fieldCode="AU" term="%22Marconato+M%22">Marconato M</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Department of Medical Oncology and Hematology, University Hospital Zurich, Zurich, Switzerland; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Hackenbruch+C%22">Hackenbruch C</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Jäger+S%22">Jäger S</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Göpel+S%22">Göpel S</searchLink>; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Кirieieva+T%22">Кirieieva T</searchLink>; Communal Non-Profit Enterprise 'City clinical hospital' of Dnipro city council, Therapy Department, Dnipro State Medical University, Dnipro, Ukraine.<br /><searchLink fieldCode="AU" term="%22Gavrylov+A%22">Gavrylov A</searchLink>; Municipal Non-Profit Enterprise of Regional Council Regional Clinical Infectious Hospital, Kharkiv, Ukraine.<br /><searchLink fieldCode="AU" term="%22Fricke+H%22">Fricke H</searchLink>; CORAT Therapeutics GmbH, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Hust+M%22">Hust M</searchLink>; Department of Medical Biotechnology, Technische Universität Braunschweig, Braunschweig, Germany; Department of Biotechnology, Technische Universität Braunschweig, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Dübel+S%22">Dübel S</searchLink>; Department of Biotechnology, Technische Universität Braunschweig, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Dings+C%22">Dings C</searchLink>; Saarmetrics GmbH, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Lehr+T%22">Lehr T</searchLink>; Saarmetrics GmbH, Saarbrücken, Germany; Clinical Pharmacy, Saarland University, Saarbrücken, Germany.<br /><searchLink fieldCode="AU" term="%22Cuevas+M%22">Cuevas M</searchLink>; TUD Dresden University of Technology, Faculty of Medicine (and University Hospital), Carl Gustav Carus Department of Otorhinolaryngology Head and Neck Surgery, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Bitzer+M%22">Bitzer M</searchLink>; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Klein+C%22">Klein C</searchLink>; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Schwab+M%22">Schwab M</searchLink>; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Departments of Clinical Pharmacology, and of Biochemistry and Pharmacy, University Tuebingen, Tuebingen, Germany; German Cancer Consortium (DKTK), partner site Tuebingen, a partnership between DKFZ and University Hospital Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wirtz+H%22">Wirtz H</searchLink>; Universitätsklinikum Leipzig Medizinische Klinik II, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schneider+J%22">Schneider J</searchLink>; Department of Internal Medicine II, TUM University Hospital Rechts der Isar, Technical University of Munich, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Bitter+T%22">Bitter T</searchLink>; Städtisches Klinikum Braunschweiq qGmbH Med. Klinik VII Klinik für Pneumoloqie und Beatmungsmedizin, Braunschweiq Germany.<br /><searchLink fieldCode="AU" term="%22Frenzel+A%22">Frenzel A</searchLink>; CORAT Therapeutics GmbH, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Dhaen+MA%22">Dhaen MA</searchLink>; CORAT Therapeutics GmbH, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Herrmann+A%22">Herrmann A</searchLink>; CORAT Therapeutics GmbH, Braunschweig, Germany.<br /><searchLink fieldCode="AU" term="%22Jung+G%22">Jung G</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Walz+JS%22">Walz JS</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tuebingen, a partnership between DKFZ and University Hospital Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Salih+HR%22">Salih HR</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tuebingen, a partnership between DKFZ and University Hospital Tuebingen, Tuebingen, Germany.<br /><searchLink fieldCode="AU" term="%22Heitmann+JS%22">Heitmann JS</searchLink>; Clinical Collaboration Unit Translational Immunology, Department of Internal Medicine, University Hospital Tübingen, Tübingen, Germany; Cluster of Excellence iFIT (EXC2180) 'Image-Guided and Functionally Instructed Tumor Therapies,' University of Tübingen, Tübingen, Germany; Department of Peptide-based Immunotherapy, Institute of Immunology, University and University Hospital Tübingen, Tübingen, Germany. Electronic address: jonas.heitmann@med.uni-tuebingen.de.
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