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Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer.

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Title: Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer.
Authors: Chey YCJ; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia., Kashgari B; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia., McLeod L; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia., Radford GA; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia., Gearing LJ; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia., Dawson RE; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia., Kharbanda M; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia., Lundy J; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.; Department of Surgery (School of Clinical Sciences at Monash Health), Monash University, Clayton, VIC, Australia.; Peninsula Clinical School, School of Translational Medicine, Monash University, Frankston, VIC, Australia., Croagh D; Department of Surgery (School of Clinical Sciences at Monash Health), Monash University, Clayton, VIC, Australia., Girard-Guyonvarc'h C; Division of Rheumatology, University Hospital of Geneva, Geneva, Switzerland.; Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland., Gabay C; Division of Rheumatology, University Hospital of Geneva, Geneva, Switzerland.; Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland., Pereira BA; Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, NSW, Australia., Herrmann D; Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, NSW, Australia., Timpson P; Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, NSW, Australia., Finnie JW; School of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia., Saad MI; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia., Bhuva DD; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia.; The University of Queensland, Brisbane, QLD, Australia., Franklin BS; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Schmidt FI; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany., Jenkins BJ; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia. brendan.jenkins@adelaide.edu.au.; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia. brendan.jenkins@adelaide.edu.au.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia. brendan.jenkins@adelaide.edu.au.
Source: Nature communications [Nat Commun] 2026 Feb 07; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: Cancer cell-intrinsic inflammasome protein ASC links innate immunity with mitochondrial metabolism in driving pancreatic cancer.
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  Data: <searchLink fieldCode="AU" term="%22Chey+YCJ%22">Chey YCJ</searchLink>; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Kashgari+B%22">Kashgari B</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22McLeod+L%22">McLeod L</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Radford+GA%22">Radford GA</searchLink>; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Gearing+LJ%22">Gearing LJ</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dawson+RE%22">Dawson RE</searchLink>; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Kharbanda+M%22">Kharbanda M</searchLink>; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Lundy+J%22">Lundy J</searchLink>; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.; Department of Surgery (School of Clinical Sciences at Monash Health), Monash University, Clayton, VIC, Australia.; Peninsula Clinical School, School of Translational Medicine, Monash University, Frankston, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Croagh+D%22">Croagh D</searchLink>; Department of Surgery (School of Clinical Sciences at Monash Health), Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Girard-Guyonvarc'h+C%22">Girard-Guyonvarc'h C</searchLink>; Division of Rheumatology, University Hospital of Geneva, Geneva, Switzerland.; Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gabay+C%22">Gabay C</searchLink>; Division of Rheumatology, University Hospital of Geneva, Geneva, Switzerland.; Department of Pathology and Immunology, University of Geneva School of Medicine, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pereira+BA%22">Pereira BA</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Herrmann+D%22">Herrmann D</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Timpson+P%22">Timpson P</searchLink>; Cancer Ecosystems Program, Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Darlinghurst, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, University of New South Wales (UNSW), Kensington, Sydney, NSW, Australia.<br /><searchLink fieldCode="AU" term="%22Finnie+JW%22">Finnie JW</searchLink>; School of Medicine, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Saad+MI%22">Saad MI</searchLink>; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Bhuva+DD%22">Bhuva DD</searchLink>; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia.; The University of Queensland, Brisbane, QLD, Australia.<br /><searchLink fieldCode="AU" term="%22Franklin+BS%22">Franklin BS</searchLink>; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+FI%22">Schmidt FI</searchLink>; Institute of Innate Immunity, Medical Faculty, University of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Jenkins+BJ%22">Jenkins BJ</searchLink>; South Australian ImmunoGENomics Cancer Institute (SAiGENCI), The University of Adelaide, Adelaide, SA, Australia. brendan.jenkins@adelaide.edu.au.; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia. brendan.jenkins@adelaide.edu.au.; Department of Molecular Translational Science, School of Clinical Sciences, Monash University, Clayton, VIC, Australia. brendan.jenkins@adelaide.edu.au.
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