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Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality.

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Title: Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality.
Authors: Fleischauer J; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., John-Neek P; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Ha TC; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Mansel F; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Kosanke M; Research Core Unit Genomics, Hannover Medical School, 30625, Hannover, Germany.; The Faculty of Health Sciences, Department of Molecular Medicine, Genome Biology, University of Southern Denmark, Odense M, 5230, Denmark., Selich A; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, 30625, Hannover, Germany., Hagedorn M; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Bastone AL; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Genewity, Oegstgeest, 2342DH, The Netherlands., Schinke M; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, Germany., Dziadek V; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany., Dittrich-Breiholz O; Research Core Unit Genomics, Hannover Medical School, 30625, Hannover, Germany., von Kaisenberg C; Department of Obstetrics and Gynecology, Hannover Medical School, 30625, Hannover, Germany., Schambach A; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Division of Hematology/Oncology, Department of Pediatric Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Rothe M; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany. Rothe.Michael@mh-hannover.de.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany. Rothe.Michael@mh-hannover.de.
Source: Journal of translational medicine [J Transl Med] 2026 Feb 07; Vol. 24 (1). Date of Electronic Publication: 2026 Feb 07.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality.
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  Data: <searchLink fieldCode="AU" term="%22Fleischauer+J%22">Fleischauer J</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22John-Neek+P%22">John-Neek P</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Ha+TC%22">Ha TC</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Mansel+F%22">Mansel F</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Kosanke+M%22">Kosanke M</searchLink>; Research Core Unit Genomics, Hannover Medical School, 30625, Hannover, Germany.; The Faculty of Health Sciences, Department of Molecular Medicine, Genome Biology, University of Southern Denmark, Odense M, 5230, Denmark.<br /><searchLink fieldCode="AU" term="%22Selich+A%22">Selich A</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hagedorn+M%22">Hagedorn M</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Bastone+AL%22">Bastone AL</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Genewity, Oegstgeest, 2342DH, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Schinke+M%22">Schinke M</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Dziadek+V%22">Dziadek V</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Dittrich-Breiholz+O%22">Dittrich-Breiholz O</searchLink>; Research Core Unit Genomics, Hannover Medical School, 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22von+Kaisenberg+C%22">von Kaisenberg C</searchLink>; Department of Obstetrics and Gynecology, Hannover Medical School, 30625, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Schambach+A%22">Schambach A</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany.; Division of Hematology/Oncology, Department of Pediatric Oncology, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Rothe+M%22">Rothe M</searchLink>; Institute of Experimental Hematology, Hannover Medical School, 30625, Hannover, Germany. Rothe.Michael@mh-hannover.de.; REBIRTH-Research Center for Translational Regenerative Medicine, Hannover Medical School, 30625, Hannover, Germany. Rothe.Michael@mh-hannover.de.
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  Data: <searchLink fieldCode="JN" term="%22101190741%22">Journal of translational medicine</searchLink> [J Transl Med] 2026 Feb 07; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Feb 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190741 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1479-5876 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214795876%22">14795876 </searchLink><i>NLM ISO Abbreviation: </i>J Transl Med <i>Subsets: </i>MEDLINE
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