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A biological-systems-based analysis using proteomic and metabolic network inference reveals mechanistic insights into hepatic steatosis.

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Title: A biological-systems-based analysis using proteomic and metabolic network inference reveals mechanistic insights into hepatic steatosis.
Authors: Atabaki NN; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Helsingborg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; The National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (BRC), OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. Electronic address: natalie.atabaki@med.lu.se., Coral DE; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Helsingborg, Sweden., Pomares-Millan H; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Helsingborg, Sweden; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, USA., Smith K; The National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (BRC), OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Behjat HH; Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden., Koivula RW; The National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (BRC), OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Tura A; Institute of Neuroscience, National Research Council, Padova, Italy., Miller H; The National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (BRC), OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Barts Liver Centre, Queen Mary University London and Barts Health NHS Trust, London, UK., Pinnick KE; The National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (BRC), OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Agudelo LZ; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, USA; Broad Institute of MIT and Harvard, Cambridge, USA., Allin KH; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brown AA; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK., Chabanova E; Department of Diagnostic Radiology, Copenhagen University Hospital Herlev Gentofte, Herlev, Denmark., Chmura PJ; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Jacobsen UP; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Dawed AY; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK., Elders PJM; Department of General Practice, Amsterdam UMC- location Vumc, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands., Fernandez-Tajes JJ; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Helsingborg, Sweden., Forgie IM; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK., Haid M; Metabolomics and Proteomics Core, German Research Center for Environmental Health, Helmholtz Zentrum München, Neuherberg, Germany., Hansen TH; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Medicine, Zealand University Hospital, Køge, Denmark., Jones AG; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, UK., Kokkola T; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Kalamajski S; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Helsingborg, Sweden., Mahajan A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., McDonald TJ; Blood Sciences, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK., McEvoy D; Diabetes Research Network, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Muilwijk M; Amsterdam UMC, Epidemiology and Data Science, Amsterdam, the Netherlands; Amsterdam Public Health, Health Behaviors & Chronic Diseases, Amsterdam, the Netherlands., Tsirigos KD; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark., Vangipurapu J; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., van Oort S; Department of General Practice, Amsterdam UMC- location Vumc, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands., Vestergaard H; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Steno Diabetes Center, Copenhagen, Denmark., Adamski J; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia., Beulens JW; Amsterdam UMC, Epidemiology and Data Science, Amsterdam, the Netherlands., Brunak S; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark., Dermitzakis ET; Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland., Giordano GN; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Helsingborg, Sweden., Gupta R; Department of Health Technology, Technical University of Denmark, Kongens Lyngby, Denmark; Disease Intelligence Pte Ltd, Singapore, Singapore., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., 't Hart LM; Amsterdam UMC, Epidemiology and Data Science, Amsterdam, the Netherlands; Amsterdam Public Health, Health Behaviors & Chronic Diseases, Amsterdam, the Netherlands; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands; Department of Biomedical Data Sciences, Section Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Hattersley AT; Department of Clinical and Biomedical Sciences, University of Exeter College of Medicine & Health, Exeter, UK., Hodson L; The National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (BRC), OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Laakso M; Internal Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland., Loos RJF; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Merino J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ohlsson M; Center for Environmental and Climate Science, Lund University, Lund, Sweden., Pedersen O; Center for Clinical Metabolic Research, Herlev and Gentofte University Hospital, Copenhagen, Denmark., Ridderstråle M; Department of Clinical Science, Lund University, Malmö, Sweden., Ruetten H; Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim, Germany., Rutters F; Amsterdam UMC, Epidemiology and Data Science, Amsterdam, the Netherlands; Amsterdam Public Health, Health Behaviors & Chronic Diseases, Amsterdam, the Netherlands., Schwenk JM; Science for Life Laboratory, Department of Protein Science, KTH Royal Institute of Technology, Stockholm, Sweden., Tomlinson J; The National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (BRC), OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Walker M; Translational and Clinical Research Institute, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK., Yaghootkar H; School of Electronics and Computer Science, Faculty of Engineering and Physical Science, University of Southampton, Southampton, UK; School of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK., Karpe F; The National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre (BRC), OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., McCarthy MI; Wellcome Centre for Human Genetics, University of Oxford, UK., Thomas EL; Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK., Bell JD; Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK., Mari A; Institute of Neuroscience, National Research Council, Padova, Italy., Pavo I; Eli Lilly Regional Operations Ges.m.b.H., Vienna, Austria., Pearson ER; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK., Viñuela A; Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK., Franks PW; Department of Clinical Science, Genetic and Molecular Epidemiology, Lund University Diabetes Centre, Helsingborg, Sweden; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK. Electronic address: paul.franks@med.lu.se.
Source: Metabolism: clinical and experimental [Metabolism] 2026 May; Vol. 178, pp. 156552. Date of Electronic Publication: 2026 Feb 06.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0375267 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8600 (Electronic) Linking ISSN: 00260495 NLM ISO Abbreviation: Metabolism Subsets: MEDLINE
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          Dates:
            – D: 01
              M: 05
              Text: 2026 May
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1532-8600
          Numbering:
            – Type: volume
              Value: 178
          Titles:
            – TitleFull: Metabolism: clinical and experimental
              Type: main
ResultId 1