Intrarenal renin-angiotensin system inactivation ameliorates tubulopathy via attenuation of mitochondrial oxidative stress, dysfunction and senescence in diabetes.

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Title: Intrarenal renin-angiotensin system inactivation ameliorates tubulopathy via attenuation of mitochondrial oxidative stress, dysfunction and senescence in diabetes.
Authors: Yang WX; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9., Pang YC; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9., Liao MC; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9., Peng J; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9., Leal DN; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, U.S.A., Yamashita M; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, U.S.A., Miyata KN; Division of Nephrology, Department of Internal Medicine, Saint Louis University, 1008 Spring Ave., Saint Louis, MO 63110, U.S.A., Filep JG; Centre de recherche, Hôpital Maisonneuve-Rosemont, Université de Montréal, 5415 boul. de l'Assomption, Montréal, QC, Canada H1T 2M4., Ingelfinger JR; Pediatric Nephrology Unit, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WAC 709, Boston, MA 02114-3117, U.S.A., Zhang SL; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9., Chan JSD; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9.
Source: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2026 Mar 11; Vol. 140 (3), pp. 321-338.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Intrarenal renin-angiotensin system inactivation ameliorates tubulopathy via attenuation of mitochondrial oxidative stress, dysfunction and senescence in diabetes.
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  Data: <searchLink fieldCode="AU" term="%22Yang+WX%22">Yang WX</searchLink>; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9.<br /><searchLink fieldCode="AU" term="%22Pang+YC%22">Pang YC</searchLink>; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9.<br /><searchLink fieldCode="AU" term="%22Liao+MC%22">Liao MC</searchLink>; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9.<br /><searchLink fieldCode="AU" term="%22Peng+J%22">Peng J</searchLink>; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9.<br /><searchLink fieldCode="AU" term="%22Leal+DN%22">Leal DN</searchLink>; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, U.S.A.<br /><searchLink fieldCode="AU" term="%22Yamashita+M%22">Yamashita M</searchLink>; Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, U.S.A.<br /><searchLink fieldCode="AU" term="%22Miyata+KN%22">Miyata KN</searchLink>; Division of Nephrology, Department of Internal Medicine, Saint Louis University, 1008 Spring Ave., Saint Louis, MO 63110, U.S.A.<br /><searchLink fieldCode="AU" term="%22Filep+JG%22">Filep JG</searchLink>; Centre de recherche, Hôpital Maisonneuve-Rosemont, Université de Montréal, 5415 boul. de l'Assomption, Montréal, QC, Canada H1T 2M4.<br /><searchLink fieldCode="AU" term="%22Ingelfinger+JR%22">Ingelfinger JR</searchLink>; Pediatric Nephrology Unit, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, WAC 709, Boston, MA 02114-3117, U.S.A.<br /><searchLink fieldCode="AU" term="%22Zhang+SL%22">Zhang SL</searchLink>; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9.<br /><searchLink fieldCode="AU" term="%22Chan+JSD%22">Chan JSD</searchLink>; Centre de recherche, Centre hospitalier de l'Université de Montréal (CRCHUM) and Département de médecine, Université de Montréal, 900 Saint Denis Street, Montréal, QC, Canada H2X 0A9.
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  Data: <searchLink fieldCode="JN" term="%227905731%22">Clinical science (London, England : 1979)</searchLink> [Clin Sci (Lond)] 2026 Mar 11; Vol. 140 (3), pp. 321-338.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Portland+Press+on+behalf+of+the+Medical+Research+Society+and+the+Biochemical+Society%22">Portland Press on behalf of the Medical Research Society and the Biochemical Society </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>7905731 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1470-8736 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201435221%22">01435221 </searchLink><i>NLM ISO Abbreviation: </i>Clin Sci (Lond) <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar 11
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