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Age and onset timing of Raynaud's phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR).

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Title: Age and onset timing of Raynaud's phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR).
Authors: Peretti S; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy., Bruni C; Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich 8091, Switzerland.; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy., Bonomi F; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy., De Angelis R; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Bajocchi G; Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy., Giuggioli D; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Orlandi M; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Zanframundo G; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Foti R; Rheumatology Unit, AOU Policlinico San Marco, Catania, Italy., Visalli E; Rheumatology Unit, AOU Policlinico San Marco, Catania, Italy., Cuomo G; Department of Precision Medicine, University of Campania-Luigi Vanvitelli University, Naples, Italy., Ariani A; Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy., Rosato E; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Lepri G; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy., Girelli F; Department of Medicine, Rheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì, Italy., Riccieri V; Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy., Zanatta E; Department of Rheumatology, University of Padua, Padova, Italy., Bosello SL; Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy., Cavazzana I; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Ingegnoli F; Clinica Reumatologica, Dipartimento di Reumatologia e Scienze Mediche, ASST Gaetano Pini-CTO, Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza, Università degli Studi di Milano, Milan, Italy., De Santis M; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan and Research Hospital, Milan, Italy., Cacciapaglia F; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy.; Rheumatology Service, Internal Medicine Unit 'F. Miulli' General Hospital, Acquaviva delle Fonti, Bari, Italy.; Department of Medicine and Surgery, LUM 'G. De Gennaro,' Casamassima, Bari, Italy., Murdaca G; Department of Internal Medicine, University of Genoa and Allergology, and Clinical Immunology Unit, Ospedale San Bartolomeo, Sarzana, Italy., Abignano G; Rheumatology Unit, Department of Health Science, San Carlo Hospital, University of Basilicata, Potenza, Italy., Pettiti G; Rheumatology Unit ASO S., Croce e Carle Hospital, Cuneo, Italy., Della Rossa A; Department of Rheumatology, University of Pisa, Pisa, Italy., Caminiti M; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Iuliano A; Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Italy., Ciano G; Local Health Department, Hospital of Ariano Irpino, Ariano Irpino, Italy., Beretta L; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy., Bagnato G; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Lubrano E; Department of Rheumatology, University of Molise, Campobasso, Italy., De Andres I; Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione Garibaldi, Catania, Italy., Idolazzi L; Rheumatology Unit, Department of Medicine, University of Verona, Verona, Italy., Saracco M; Rheumatology Unit, Mauriziano-Umberto I Hospital, Turin, Italy., Agnes C; Division of Rehabilitation, Department of Medicine, Torino, ASL TO5, Carmagnola, Italy., Campochiaro C; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., De Luca G; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Cipolletta E; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy., Fornaro M; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy., Lumetti F; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Spinella A; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., Magnani L; Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy., Codullo V; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Iandoli C; Department of Precision Medicine, University of Campania-Luigi Vanvitelli University, Naples, Italy., Gigante A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Pellegrino G; Department of Rheumatology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.; Dipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Milan, Italy., Pigatto E; Department of Medicine, Villa Salus Hospital, Mestre, Italy., Lazzaroni MG; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., De Lorenzis E; Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy., Mennillo GA; Rheumatology Unit, Department of Health Science, San Carlo Hospital, University of Basilicata, Potenza, Italy., Battista MD; Department of Rheumatology, University of Pisa, Pisa, Italy., Pagano Mariano G; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy., Furini F; Department of Medicine, Villa Salus Hospital, Mestre, Italy., Vultaggio L; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy., Parisi S; Rheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e della Scienza di Torino, Turin, Italy., Peroni CL; Rheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e della Scienza di Torino, Turin, Italy., Bianchi G; Rheumatology Unit, Department of Medical Specialities, Local Health Trust 3, Genoa, Italy., Fusaro E; Rheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e della Scienza di Torino, Turin, Italy., Sebastiani GD; Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Italy., Govoni M; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy., D'Angelo S; Rheumatology Unit, Department of Health Science, San Carlo Hospital, University of Basilicata, Potenza, Italy., Cozzi F; Department of Medicine, Villa Salus Hospital, Mestre, Italy., Franceschini F; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy., Guiducci S; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy., Dagna L; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Doria A; Department of Rheumatology, University of Padua, Padova, Italy., Salvarani C; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy., D'Agostino MA; Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy., Iannone F; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy., Matucci-Cerinic M; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy., Ferri C; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.; Rheumatology Clinic 'Madonna dello Scoglio' Crotonei, Crotone, Italy., Randone SB; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy.
Source: Therapeutic advances in musculoskeletal disease [Ther Adv Musculoskelet Dis] 2026 Feb 05; Vol. 18, pp. 1759720X251410243. Date of Electronic Publication: 2026 Feb 05 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Sage Country of Publication: England NLM ID: 101517322 Publication Model: eCollection Cited Medium: Print ISSN: 1759-720X (Print) Linking ISSN: 1759720X NLM ISO Abbreviation: Ther Adv Musculoskelet Dis Subsets: PubMed not MEDLINE
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Age and onset timing of Raynaud's phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR).
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Peretti+S%22">Peretti S</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Bruni+C%22">Bruni C</searchLink>; Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich 8091, Switzerland.; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Bonomi+F%22">Bonomi F</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22De+Angelis+R%22">De Angelis R</searchLink>; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Bajocchi+G%22">Bajocchi G</searchLink>; Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Giuggioli+D%22">Giuggioli D</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Orlandi+M%22">Orlandi M</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Zanframundo+G%22">Zanframundo G</searchLink>; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Foti+R%22">Foti R</searchLink>; Rheumatology Unit, AOU Policlinico San Marco, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Visalli+E%22">Visalli E</searchLink>; Rheumatology Unit, AOU Policlinico San Marco, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Cuomo+G%22">Cuomo G</searchLink>; Department of Precision Medicine, University of Campania-Luigi Vanvitelli University, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Ariani+A%22">Ariani A</searchLink>; Department of Medicine, Internal Medicine and Rheumatology, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.<br /><searchLink fieldCode="AU" term="%22Rosato+E%22">Rosato E</searchLink>; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Lepri+G%22">Lepri G</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Girelli+F%22">Girelli F</searchLink>; Department of Medicine, Rheumatology Unit, Ospedale GB Morgagni-L Pierantoni, Forlì, Italy.<br /><searchLink fieldCode="AU" term="%22Riccieri+V%22">Riccieri V</searchLink>; Department of Internal Medicine, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Zanatta+E%22">Zanatta E</searchLink>; Department of Rheumatology, University of Padua, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Bosello+SL%22">Bosello SL</searchLink>; Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Cavazzana+I%22">Cavazzana I</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Ingegnoli+F%22">Ingegnoli F</searchLink>; Clinica Reumatologica, Dipartimento di Reumatologia e Scienze Mediche, ASST Gaetano Pini-CTO, Dipartimento di Scienze Cliniche e di Comunità, Dipartimento di Eccellenza, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Santis+M%22">De Santis M</searchLink>; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan and Research Hospital, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cacciapaglia+F%22">Cacciapaglia F</searchLink>; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy.; Rheumatology Service, Internal Medicine Unit 'F. Miulli' General Hospital, Acquaviva delle Fonti, Bari, Italy.; Department of Medicine and Surgery, LUM 'G. De Gennaro,' Casamassima, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Murdaca+G%22">Murdaca G</searchLink>; Department of Internal Medicine, University of Genoa and Allergology, and Clinical Immunology Unit, Ospedale San Bartolomeo, Sarzana, Italy.<br /><searchLink fieldCode="AU" term="%22Abignano+G%22">Abignano G</searchLink>; Rheumatology Unit, Department of Health Science, San Carlo Hospital, University of Basilicata, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Pettiti+G%22">Pettiti G</searchLink>; Rheumatology Unit ASO S., Croce e Carle Hospital, Cuneo, Italy.<br /><searchLink fieldCode="AU" term="%22Della+Rossa+A%22">Della Rossa A</searchLink>; Department of Rheumatology, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Caminiti+M%22">Caminiti M</searchLink>; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Iuliano+A%22">Iuliano A</searchLink>; Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Ciano+G%22">Ciano G</searchLink>; Local Health Department, Hospital of Ariano Irpino, Ariano Irpino, Italy.<br /><searchLink fieldCode="AU" term="%22Beretta+L%22">Beretta L</searchLink>; Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Bagnato+G%22">Bagnato G</searchLink>; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.<br /><searchLink fieldCode="AU" term="%22Lubrano+E%22">Lubrano E</searchLink>; Department of Rheumatology, University of Molise, Campobasso, Italy.<br /><searchLink fieldCode="AU" term="%22De+Andres+I%22">De Andres I</searchLink>; Rheumatology Unit, Azienda Ospedaliera di Rilievo Nazionale ed Alta Specializzazione Garibaldi, Catania, Italy.<br /><searchLink fieldCode="AU" term="%22Idolazzi+L%22">Idolazzi L</searchLink>; Rheumatology Unit, Department of Medicine, University of Verona, Verona, Italy.<br /><searchLink fieldCode="AU" term="%22Saracco+M%22">Saracco M</searchLink>; Rheumatology Unit, Mauriziano-Umberto I Hospital, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Agnes+C%22">Agnes C</searchLink>; Division of Rehabilitation, Department of Medicine, Torino, ASL TO5, Carmagnola, Italy.<br /><searchLink fieldCode="AU" term="%22Campochiaro+C%22">Campochiaro C</searchLink>; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Luca+G%22">De Luca G</searchLink>; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Cipolletta+E%22">Cipolletta E</searchLink>; Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, Ancona, Italy.<br /><searchLink fieldCode="AU" term="%22Fornaro+M%22">Fornaro M</searchLink>; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Lumetti+F%22">Lumetti F</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Spinella+A%22">Spinella A</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22Magnani+L%22">Magnani L</searchLink>; Rheumatology Unit, S. Maria Hospital-USL, IRCCS Institute, Reggio Emilia, Italy.<br /><searchLink fieldCode="AU" term="%22Codullo+V%22">Codullo V</searchLink>; Department of Internal Medicine and Therapeutics, Università di Pavia, Pavia, Italy.; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.<br /><searchLink fieldCode="AU" term="%22Iandoli+C%22">Iandoli C</searchLink>; Department of Precision Medicine, University of Campania-Luigi Vanvitelli University, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Gigante+A%22">Gigante A</searchLink>; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Pellegrino+G%22">Pellegrino G</searchLink>; Department of Rheumatology, IRCCS Ospedale Galeazzi-Sant'Ambrogio, Milan, Italy.; Dipartimento di Scienze Biomediche e Cliniche, Università degli Studi di Milano, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Pigatto+E%22">Pigatto E</searchLink>; Department of Medicine, Villa Salus Hospital, Mestre, Italy.<br /><searchLink fieldCode="AU" term="%22Lazzaroni+MG%22">Lazzaroni MG</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22De+Lorenzis+E%22">De Lorenzis E</searchLink>; Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Mennillo+GA%22">Mennillo GA</searchLink>; Rheumatology Unit, Department of Health Science, San Carlo Hospital, University of Basilicata, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Battista+MD%22">Battista MD</searchLink>; Department of Rheumatology, University of Pisa, Pisa, Italy.<br /><searchLink fieldCode="AU" term="%22Pagano+Mariano+G%22">Pagano Mariano G</searchLink>; Departmental Rheumatology Unit, Grande Ospedale Metropolitano, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Furini+F%22">Furini F</searchLink>; Department of Medicine, Villa Salus Hospital, Mestre, Italy.<br /><searchLink fieldCode="AU" term="%22Vultaggio+L%22">Vultaggio L</searchLink>; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22Parisi+S%22">Parisi S</searchLink>; Rheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Peroni+CL%22">Peroni CL</searchLink>; Rheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Bianchi+G%22">Bianchi G</searchLink>; Rheumatology Unit, Department of Medical Specialities, Local Health Trust 3, Genoa, Italy.<br /><searchLink fieldCode="AU" term="%22Fusaro+E%22">Fusaro E</searchLink>; Rheumatology Unit, Azienda Ospedaliera Universitaria Città Della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Sebastiani+GD%22">Sebastiani GD</searchLink>; Rheumatology Unit, San Camillo-Forlanini Hospital, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Govoni+M%22">Govoni M</searchLink>; Rheumatology Unit, Department of Medical Sciences, University of Ferrara and Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy.<br /><searchLink fieldCode="AU" term="%22D'Angelo+S%22">D'Angelo S</searchLink>; Rheumatology Unit, Department of Health Science, San Carlo Hospital, University of Basilicata, Potenza, Italy.<br /><searchLink fieldCode="AU" term="%22Cozzi+F%22">Cozzi F</searchLink>; Department of Medicine, Villa Salus Hospital, Mestre, Italy.<br /><searchLink fieldCode="AU" term="%22Franceschini+F%22">Franceschini F</searchLink>; Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Brescia, Italy.; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Guiducci+S%22">Guiducci S</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy.<br /><searchLink fieldCode="AU" term="%22Dagna+L%22">Dagna L</searchLink>; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Doria+A%22">Doria A</searchLink>; Department of Rheumatology, University of Padua, Padova, Italy.<br /><searchLink fieldCode="AU" term="%22Salvarani+C%22">Salvarani C</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.<br /><searchLink fieldCode="AU" term="%22D'Agostino+MA%22">D'Agostino MA</searchLink>; Rheumatology Division, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Iannone+F%22">Iannone F</searchLink>; Rheumatology Unit, Department of Precision and Regenerative Medicine-Ionian Area, University of Bari 'Aldo Moro,' Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Matucci-Cerinic+M%22">Matucci-Cerinic M</searchLink>; IRCCS San Raffaele Scientific Institute, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, & Inflammation, Fibrosis and Ageing initiative, Milan, Italy.; Vita-Salute San Raffaele University, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Ferri+C%22">Ferri C</searchLink>; Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia School of Medicine, Modena, Italy.; Rheumatology Clinic 'Madonna dello Scoglio' Crotonei, Crotone, Italy.<br /><searchLink fieldCode="AU" term="%22Randone+SB%22">Randone SB</searchLink>; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.; Division of Rheumatology, Department of Medical and Geriatric specialties, Careggi University Hospital, University of Florence, Florence, Italy.
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  Data: <searchLink fieldCode="JN" term="%22101517322%22">Therapeutic advances in musculoskeletal disease</searchLink> [Ther Adv Musculoskelet Dis] 2026 Feb 05; Vol. 18, pp. 1759720X251410243. <i>Date of Electronic Publication: </i>2026 Feb 05 (<i>Print Publication: </i>2026).
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        Value: 10.1177/1759720X251410243
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        Text: English
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      – TitleFull: Age and onset timing of Raynaud's phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR).
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            – D: 05
              M: 02
              Text: 2026 Feb 05
              Type: published
              Y: 2026
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            – TitleFull: Therapeutic advances in musculoskeletal disease
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