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ASSOCIATION ANALYSIS OF MITOCHONDRIAL HETEROPLASMIC VARIANTS AND CARDIOMETABOLIC TRAITS.

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Title: ASSOCIATION ANALYSIS OF MITOCHONDRIAL HETEROPLASMIC VARIANTS AND CARDIOMETABOLIC TRAITS.
Authors: Sun X; Department of Biostatistics, Boston University School of Public Health., Liu X; Department of Biostatistics, Boston University School of Public Health., Bulekova K; Research Computing Services, Boston University, Boston, MA 02215, USA., Pitsillides AN; Department of Biostatistics, Boston University School of Public Health., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Yong Q; Longitudinal Studies Section, Translational Gerontology Branch, NIA/NIH, Baltimore, MD 21224, USA., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA., Rich SS; Department of Public Health Services, Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA., Abecasis G; TOPMed Informatics Research Center, University of Michigan, Ann Arbor, MI 48109, USA., Carson AP; Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA., Vasan RS; Sections of Preventive Medicine and Epidemiology, and Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.; Framingham Heart Study, NHLBI/NIH, Framingham, MA 01702, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.; Departments of Epidemiology, and Health Services, University of Washington, Seattle, WA 98101, USA., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA., Fitzpatrick AL; Departments of Family Medicine, Epidemiology, and Global Health, University of Washington, Seattle, WA 98195, USA., Satizabal CL; Framingham Heart Study, NHLBI/NIH, Framingham, MA 01702, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21205, US., Ding J; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA., Levy D; Framingham Heart Study, NHLBI/NIH, Framingham, MA 01702, USA., Liu C; Department of Biostatistics, Boston University School of Public Health.; Framingham Heart Study, NHLBI/NIH, Framingham, MA 01702, USA.
Corporate Authors: TOPMed mtDNA working group
Source: MedRxiv : the preprint server for health sciences [medRxiv] 2026 Jan 25. Date of Electronic Publication: 2026 Jan 25.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: ASSOCIATION ANALYSIS OF MITOCHONDRIAL HETEROPLASMIC VARIANTS AND CARDIOMETABOLIC TRAITS.
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  Data: <searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; Department of Biostatistics, Boston University School of Public Health.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Biostatistics, Boston University School of Public Health.<br /><searchLink fieldCode="AU" term="%22Bulekova+K%22">Bulekova K</searchLink>; Research Computing Services, Boston University, Boston, MA 02215, USA.<br /><searchLink fieldCode="AU" term="%22Pitsillides+AN%22">Pitsillides AN</searchLink>; Department of Biostatistics, Boston University School of Public Health.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.<br /><searchLink fieldCode="AU" term="%22Yong+Q%22">Yong Q</searchLink>; Longitudinal Studies Section, Translational Gerontology Branch, NIA/NIH, Baltimore, MD 21224, USA.<br /><searchLink fieldCode="AU" term="%22Raffield+LM%22">Raffield LM</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.<br /><searchLink fieldCode="AU" term="%22Rotter+JI%22">Rotter JI</searchLink>; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.<br /><searchLink fieldCode="AU" term="%22Rich+SS%22">Rich SS</searchLink>; Department of Public Health Services, Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.<br /><searchLink fieldCode="AU" term="%22Abecasis+G%22">Abecasis G</searchLink>; TOPMed Informatics Research Center, University of Michigan, Ann Arbor, MI 48109, USA.<br /><searchLink fieldCode="AU" term="%22Carson+AP%22">Carson AP</searchLink>; Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.<br /><searchLink fieldCode="AU" term="%22Vasan+RS%22">Vasan RS</searchLink>; Sections of Preventive Medicine and Epidemiology, and Cardiovascular Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.; Framingham Heart Study, NHLBI/NIH, Framingham, MA 01702, USA.<br /><searchLink fieldCode="AU" term="%22Bis+JC%22">Bis JC</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Psaty+BM%22">Psaty BM</searchLink>; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98101, USA.; Departments of Epidemiology, and Health Services, University of Washington, Seattle, WA 98101, USA.<br /><searchLink fieldCode="AU" term="%22Boerwinkle+E%22">Boerwinkle E</searchLink>; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Fitzpatrick+AL%22">Fitzpatrick AL</searchLink>; Departments of Family Medicine, Epidemiology, and Global Health, University of Washington, Seattle, WA 98195, USA.<br /><searchLink fieldCode="AU" term="%22Satizabal+CL%22">Satizabal CL</searchLink>; Framingham Heart Study, NHLBI/NIH, Framingham, MA 01702, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.<br /><searchLink fieldCode="AU" term="%22Arking+DE%22">Arking DE</searchLink>; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21205, US.<br /><searchLink fieldCode="AU" term="%22Ding+J%22">Ding J</searchLink>; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.<br /><searchLink fieldCode="AU" term="%22Levy+D%22">Levy D</searchLink>; Framingham Heart Study, NHLBI/NIH, Framingham, MA 01702, USA.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; Department of Biostatistics, Boston University School of Public Health.; Framingham Heart Study, NHLBI/NIH, Framingham, MA 01702, USA.
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        Text: English
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