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A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

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Title: A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
Authors: Coulombe-Huntington J; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Bioengineering, McGill University, Montreal, QC, Canada., Bertomeu T; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; ChemoGenix CRISPR Screening Platform, Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Huard C; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Chatr-Aryamontri A; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; ChemoGenix CRISPR Screening Platform, Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., St-Cyr DJ; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; X-Chem, Inc., 4800 Rue Levy, Montréal, QC, Canada, H4R 2P7., Sánchez-Osuna M; Program in Molecular Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., Papadopoli D; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada., Normandin K; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Paydar M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., McLaughlan S; Department of Biochemistry, McGill University, Montreal, QC, Canada., St-Denis C; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Zhang L; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; ChemoGenix CRISPR Screening Platform, Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Say H; Program in Molecular Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., Palou R; Program in Molecular Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., Stark C; Program in Molecular Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., Breitkreutz BJ; Program in Molecular Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada., van der Sloot AM; The Québec Artificial Intelligence Institute, Mila, Montréal, QC, Canada., Manohar S; Department of Molecular Mechanisms of Disease, Universität Zürich, Zurich, Switzerland., Lavoie H; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada., Borden KLB; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Pharmacology, The Robert H Lurie Comprehensive Cancer Centre, Northwestern University, IL, USA., Raught B; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada., D'Amours D; Ottawa Institute of Systems Biology, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada., Sicheri F; The Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Verreault A; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Pathology and Cell Biology, Université de Montréal, Montreal, QC, Canada., Mader S; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada., Meloche S; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Pharmacology and Physiology, Université de Montréal, Montreal, QC, Canada., Therrien M; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Pathology and Cell Biology, Université de Montréal, Montreal, QC, Canada., Thibault P; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Chemistry, Université de Montréal, Montréal, QC, Canada., Wilhelm B; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Medicine, Université de Montréal, Montréal, QC, Canada., Dirks PB; Program in Developmental, Stem Cell & Cancer Biology, Division of Neurosurgery, The Hospital for Sick Children, Toronto, ON, Canada., Aitchison JD; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Departments of Pediatrics and Biochemistry, University of Washington, WA, USA., Patton E; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, United Kingdom., King RW; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Roux PP; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Pathology and Cell Biology, Université de Montréal, Montreal, QC, Canada., Sauvageau G; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Medicine, Université de Montréal, Montréal, QC, Canada., Hoang T; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Pathology and Cell Biology, Université de Montréal, Montreal, QC, Canada., Marinier A; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Chemistry, Université de Montréal, Montréal, QC, Canada., Harrington L; Department of Biochemistry, University of Toronto, Toronto, ON, Canada., Kwok B; Department of Oral Biology, College of Dentistry, University of Nebraska Medical Center, Lincoln, NE, USA., Archambault V; Institute for Research in Immunology and Cancer, Université de Montréal, Montreal, QC, Canada.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada., Topisirovic I; Gerald Bronfman Department of Oncology, McGill University, Montreal, QC, Canada.; Department of Biochemistry, McGill University, Montreal, QC, Canada., Tyers M; Program in Molecular Medicine, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 30. Date of Electronic Publication: 2026 Jan 30.
Publication Type: Journal Article; Preprint
Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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