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Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production.

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Title: Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production.
Authors: Wang Z; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences&Peking Union Medical College, Suzhou 215123, China.; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China., Chen Y; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Feng Y; State Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, School of Life Sciences, Fudan University, Shanghai, China., Zu G; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Wang W; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Liang L; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences&Peking Union Medical College, Suzhou 215123, China.; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China., Liu X; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Mei Y; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Yang J; HanGene Biotech, Xiaoshan Innovation Polis, Hangzhou, Zhejiang 31200, China., Wang T; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China., Liu M; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China., Jiang L; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China., Snell RG; Applied Translational Genetics Group, School of Biological Sciences, the University of Auckland, Auckland, New Zealand., Highet B; Department of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand., Curtis M; Department of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand., Chen L; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Li SB; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China., Wu J; Glioma Surgery Division, Neurological Surgery Department of Huashan Hospital, Fudan University, Shanghai 200040, China., Zhang M; State Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, School of Life Sciences, Fudan University, Shanghai, China.; Research Institute of Intelligent Complex Systems and Institute of Modern Languages and Linguistics, Fudan University, Shanghai 200437, China., Li W; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Wei GH; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences&Peking Union Medical College, Suzhou 215123, China.; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China., You L; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.; Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Shanghai 200032, China.
Source: IScience [iScience] 2026 Jan 14; Vol. 29 (2), pp. 114692. Date of Electronic Publication: 2026 Jan 14 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences&Peking Union Medical College, Suzhou 215123, China.; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Feng+Y%22">Feng Y</searchLink>; State Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, School of Life Sciences, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Zu+G%22">Zu G</searchLink>; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Wang+W%22">Wang W</searchLink>; Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Liang+L%22">Liang L</searchLink>; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences&Peking Union Medical College, Suzhou 215123, China.; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Liu+X%22">Liu X</searchLink>; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Mei+Y%22">Mei Y</searchLink>; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; HanGene Biotech, Xiaoshan Innovation Polis, Hangzhou, Zhejiang 31200, China.<br /><searchLink fieldCode="AU" term="%22Wang+T%22">Wang T</searchLink>; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; 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Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Glioma Surgery Division, Neurological Surgery Department of Huashan Hospital, Fudan University, Shanghai 200040, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; State Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, School of Life Sciences, Fudan University, Shanghai, China.; Research Institute of Intelligent Complex Systems and Institute of Modern Languages and Linguistics, Fudan University, Shanghai 200437, China.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22Wei+GH%22">Wei GH</searchLink>; State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences&Peking Union Medical College, Suzhou 215123, China.; MOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China.<br /><searchLink fieldCode="AU" term="%22You+L%22">You L</searchLink>; Department of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.; Key Laboratory of Medical Imaging Computing and Computer Assisted Intervention of Shanghai, Shanghai 200032, China.
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