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Comparative Effectiveness of Brivaracetam, Cenobamate, Lacosamide, and Perampanel in Focal Epilepsy.

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Title: Comparative Effectiveness of Brivaracetam, Cenobamate, Lacosamide, and Perampanel in Focal Epilepsy.
Authors: Cerulli Irelli E; Department of Human Neurosciences, Sapienza University, Rome, Italy., Roberti R; CRUISE Research Center, Science of Health Department, Magna Græcia University, Catanzaro, Italy., Borioni MS; Department of Human Neurosciences, Sapienza University, Rome, Italy., Anzellotti F; Department of Neurology, Epilepsy Center, SS Annunziata Hospital, Chieti, Italy., Belcastro V; Neurology Unit, Maggiore Hospital, ASST Lodi, Lodi, Italy., Beretta S; Department of Neurology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy., Boero G; Complex Structure of Neurology, SS Annunziata Hospital, Taranto, Italy., Bonanni P; Scientific Institute, IRCCS Eugenio Medea, Epilepsy and Clinical Neurophysiology Unit, Conegliano, Treviso, Italy., Chiesa V; Epilepsy Center, Azienda Socio Sanitaria Territoriale Santi Paolo Carlo, Milan, Italy., D'Aniello A; IRCCS NEUROMED, Pozzilli, Italy., Dainese F; Clinical Neurophysiology Unit, Clinical Neurology, DIDAS Department, Padua, Italy., Deleo F; Integrated Diagnostics for Epilepsy, Fondazione IRCCS Istituto Neurologico Besta, Milan, Italy., De Maria G; Clinical Neurophysiology Unit, Epilepsy Center, Spedali Civili, Brescia, Italy., Di Gennaro G; Clinical Neurophysiology Unit, Clinical Neurology, DIDAS Department, Padua, Italy., Di Gennaro G; CRUISE Research Center, Science of Health Department, Magna Græcia University, Catanzaro, Italy., Didato G; Epilepsy Unit, Fondazione IRCCS Istituto Neurologico Besta, Milan, Italy., Dono F; Department of Neurology, Epilepsy Center, SS Annunziata Hospital, Chieti, Italy.; Department of Neuroscience, Imaging and Clinical Science, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy., Falcicchio G; DiBraiN Department, University of Bari Aldo Moro, Bari, Italy., Ferlazzo E; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy.; Regional Epilepsy Centre, Bianchi-Melacrino-Morelli Great Metropolitan Hospital, Reggio Calabria, Italy., Fortunato F; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., La Neve A; DiBraiN Department, University of Bari Aldo Moro, Bari, Italy., Mecarelli O; Department of Human Neurosciences, Sapienza University, Rome, Italy., Montalenti E; Epilepsy Center, AOU Città della Salute e della Scienza di Torino, Turin, Italy., Morano A; Department of Human Neurosciences, Sapienza University, Rome, Italy., Nilo A; Clinical Neurology Unit, Department of Medicine, University of Udine, Udine, Italy., Operto FF; CRUISE Research Center, Science of Health Department, Magna Græcia University, Catanzaro, Italy.; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy., Paladin F; Neurology Unit, Epilepsy Center, Venice, Italy., Pascarella A; Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Catanzaro, Italy.; Regional Epilepsy Centre, Bianchi-Melacrino-Morelli Great Metropolitan Hospital, Reggio Calabria, Italy., Pauletto G; Neurology Unit, Department of Head, Neck and Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy., Pietrafusa N; Neurology, Epilepsy and Movement Disorders, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network EpiCARE, Rome, Italy., Pignatta P; Neurology and Epilepsy Unit, Humanitas Gradenigo Hospital, Torino, Italy., Pulitano P; Department of Human Neurosciences, Sapienza University, Rome, Italy., Renna R; Neurology and Stroke Unit, Department of Neurosciences, AORN San Pio, Benevento, Italy., Rosati E; Emergency Neurology, Careggi University Hospital, Florence, Italy., Sammarra I; Regional Epilepsy Centre, Bianchi-Melacrino-Morelli Great Metropolitan Hospital, Reggio Calabria, Italy., Di Bonaventura C; Department of Human Neurosciences, Sapienza University, Rome, Italy., Russo E; CRUISE Research Center, Science of Health Department, Magna Græcia University, Catanzaro, Italy., Lattanzi S; Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
Corporate Authors: Comparative REal-World Evidence (CREW) Study Group
Source: JAMA neurology [JAMA Neurol] 2026 Apr 01; Vol. 83 (4), pp. 320-328.
Publication Type: Journal Article; Comparative Study; Multicenter Study
Journal Info: Publisher: American Medical Association Country of Publication: United States NLM ID: 101589536 Publication Model: Print Cited Medium: Internet ISSN: 2168-6157 (Electronic) Linking ISSN: 21686149 NLM ISO Abbreviation: JAMA Neurol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Comparative Effectiveness of Brivaracetam, Cenobamate, Lacosamide, and Perampanel in Focal Epilepsy.
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Complex Structure of Neurology, SS Annunziata Hospital, Taranto, Italy.<br /><searchLink fieldCode="AU" term="%22Bonanni+P%22">Bonanni P</searchLink>; Scientific Institute, IRCCS Eugenio Medea, Epilepsy and Clinical Neurophysiology Unit, Conegliano, Treviso, Italy.<br /><searchLink fieldCode="AU" term="%22Chiesa+V%22">Chiesa V</searchLink>; Epilepsy Center, Azienda Socio Sanitaria Territoriale Santi Paolo Carlo, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22D'Aniello+A%22">D'Aniello A</searchLink>; IRCCS NEUROMED, Pozzilli, Italy.<br /><searchLink fieldCode="AU" term="%22Dainese+F%22">Dainese F</searchLink>; Clinical Neurophysiology Unit, Clinical Neurology, DIDAS Department, Padua, Italy.<br /><searchLink fieldCode="AU" term="%22Deleo+F%22">Deleo F</searchLink>; Integrated Diagnostics for Epilepsy, Fondazione IRCCS Istituto Neurologico Besta, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22De+Maria+G%22">De Maria G</searchLink>; Clinical Neurophysiology Unit, Epilepsy Center, Spedali Civili, Brescia, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Gennaro+G%22">Di Gennaro G</searchLink>; 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Regional Epilepsy Centre, Bianchi-Melacrino-Morelli Great Metropolitan Hospital, Reggio Calabria, Italy.<br /><searchLink fieldCode="AU" term="%22Fortunato+F%22">Fortunato F</searchLink>; Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.<br /><searchLink fieldCode="AU" term="%22La+Neve+A%22">La Neve A</searchLink>; DiBraiN Department, University of Bari Aldo Moro, Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Mecarelli+O%22">Mecarelli O</searchLink>; Department of Human Neurosciences, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Montalenti+E%22">Montalenti E</searchLink>; Epilepsy Center, AOU Città della Salute e della Scienza di Torino, Turin, Italy.<br /><searchLink fieldCode="AU" term="%22Morano+A%22">Morano A</searchLink>; Department of Human Neurosciences, Sapienza University, Rome, Italy.<br /><searchLink fieldCode="AU" term="%22Nilo+A%22">Nilo A</searchLink>; Clinical Neurology Unit, Department of Medicine, University of Udine, Udine, Italy.<br /><searchLink fieldCode="AU" term="%22Operto+FF%22">Operto FF</searchLink>; 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Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
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