Study protocol for a multicenter phase II prospective externally controlled non-inferiority trial of hypofractionated re-irradiation in patients with recurrent high-grade glioma (RISinG).
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| Title: | Study protocol for a multicenter phase II prospective externally controlled non-inferiority trial of hypofractionated re-irradiation in patients with recurrent high-grade glioma (RISinG). |
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| Authors: | de Jong AM; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., van der Boog ATJ; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Post CCB; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Cialdella F; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Eekers DBP; Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, the Netherlands., Hendrikse J; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands., Kramer MCA; Department of Radiation Oncology, University Medical Center Groningen, Groningen, the Netherlands., Lagerwaard FJ; Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, the Netherlands., van der Meulen M; Department of Neurology, Medisch Spectrum Twente, Enschede/ department of Neurology Leiden University Medical Center, Leiden, the Netherlands., Philippens MEP; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Robe PA; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Rozema T; Department of Radiation Oncology, Instituut Verbeeten, Tilburg, the Netherlands., de Vos FYFL; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Vos-Westerman J; Department of Radiation Oncology, Isala Klinieken, Zwolle, the Netherlands., van der Weide HL; Department of Radiation Oncology, University Medical Center Groningen, Groningen, the Netherlands., Wester G; Department of Radiation Oncology, Radiotherapiegroep Arnhem, Apeldoorn, Deventer, Ede, the Netherlands., Zindler J; Department of Radiation Oncology, Haaglanden Medisch Centrum, Den Haag, the Netherlands., Snijders TJ; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands., Verhoeff JJC; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, the Netherlands. |
| Source: | PloS one [PLoS One] 2026 Feb 09; Vol. 21 (2), pp. e0342337. Date of Electronic Publication: 2026 Feb 09 (Print Publication: 2026). |
| Publication Type: | Journal Article; Clinical Trial Protocol |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41662245 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Study protocol for a multicenter phase II prospective externally controlled non-inferiority trial of hypofractionated re-irradiation in patients with recurrent high-grade glioma (RISinG). – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22de+Jong+AM%22">de Jong AM</searchLink>; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Boog+ATJ%22">van der Boog ATJ</searchLink>; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Post+CCB%22">Post CCB</searchLink>; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Cialdella+F%22">Cialdella F</searchLink>; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Eekers+DBP%22">Eekers DBP</searchLink>; Department of Radiation Oncology (Maastro), GROW School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Hendrikse+J%22">Hendrikse J</searchLink>; Department of Radiology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Kramer+MCA%22">Kramer MCA</searchLink>; Department of Radiation Oncology, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Lagerwaard+FJ%22">Lagerwaard FJ</searchLink>; Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Meulen+M%22">van der Meulen M</searchLink>; Department of Neurology, Medisch Spectrum Twente, Enschede/ department of Neurology Leiden University Medical Center, Leiden, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Philippens+MEP%22">Philippens MEP</searchLink>; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Robe+PA%22">Robe PA</searchLink>; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rozema+T%22">Rozema T</searchLink>; Department of Radiation Oncology, Instituut Verbeeten, Tilburg, the Netherlands.<br /><searchLink fieldCode="AU" term="%22de+Vos+FYFL%22">de Vos FYFL</searchLink>; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Vos-Westerman+J%22">Vos-Westerman J</searchLink>; Department of Radiation Oncology, Isala Klinieken, Zwolle, the Netherlands.<br /><searchLink fieldCode="AU" term="%22van+der+Weide+HL%22">van der Weide HL</searchLink>; Department of Radiation Oncology, University Medical Center Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Wester+G%22">Wester G</searchLink>; Department of Radiation Oncology, Radiotherapiegroep Arnhem, Apeldoorn, Deventer, Ede, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Zindler+J%22">Zindler J</searchLink>; Department of Radiation Oncology, Haaglanden Medisch Centrum, Den Haag, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Snijders+TJ%22">Snijders TJ</searchLink>; Department of Neurology & Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Verhoeff+JJC%22">Verhoeff JJC</searchLink>; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, the Netherlands.; Department of Radiation Oncology, Amsterdam University Medical Center, Amsterdam, the Netherlands. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2026 Feb 09; Vol. 21 (2), pp. e0342337. <i>Date of Electronic Publication: </i>2026 Feb 09 (<i>Print Publication: </i>2026). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial Protocol – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101285081 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-6203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219326203%22">19326203 </searchLink><i>NLM ISO Abbreviation: </i>PLoS One <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41662245 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pone.0342337 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e0342337 Titles: – TitleFull: Study protocol for a multicenter phase II prospective externally controlled non-inferiority trial of hypofractionated re-irradiation in patients with recurrent high-grade glioma (RISinG). Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: de Jong AM – PersonEntity: Name: NameFull: van der Boog ATJ – PersonEntity: Name: NameFull: Post CCB – PersonEntity: Name: NameFull: Cialdella F – PersonEntity: Name: NameFull: Eekers DBP – PersonEntity: Name: NameFull: Hendrikse J – PersonEntity: Name: NameFull: Kramer MCA – PersonEntity: Name: NameFull: Lagerwaard FJ – PersonEntity: Name: NameFull: van der Meulen M – PersonEntity: Name: NameFull: Philippens MEP – PersonEntity: Name: NameFull: Robe PA – PersonEntity: Name: NameFull: Rozema T – PersonEntity: Name: NameFull: de Vos FYFL – PersonEntity: Name: NameFull: Vos-Westerman J – PersonEntity: Name: NameFull: van der Weide HL – PersonEntity: Name: NameFull: Wester G – PersonEntity: Name: NameFull: Zindler J – PersonEntity: Name: NameFull: Snijders TJ – PersonEntity: Name: NameFull: Verhoeff JJC IsPartOfRelationships: – BibEntity: Dates: – D: 09 M: 02 Text: 2026 Feb 09 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1932-6203 Numbering: – Type: volume Value: 21 – Type: issue Value: 2 Titles: – TitleFull: PloS one Type: main |
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