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Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor.

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Title: Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor.
Authors: Papillon JPN; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Yuan J; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Hesse MJ; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Zhang L; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Robinson RI; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Ware NF; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Hornak V; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Karki RG; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Kirrane T; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Garland K; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Joseph S; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Moquin SA; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.; Global Health, Biomedical Research, Novartis, Emeryville, California 94608, United States., Lakshminarayana SB; Pharmaceutical Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Tandeske L; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Dovala D; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Knapp M; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Ornelas E; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Fuller D; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Ho PI; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Xie X; University of Texas Medical Branch, Galveston, Texas 77555, United States., Vulic K; Technical Research & Development, Development, Novartis, Cambridge, Massachusetts 02139, United States., Skolnik SM; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Gao J; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Zambrowski M; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Spiess M; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Duca JS; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Busby SA; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Schirle M; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Robinson M; Global Health, Biomedical Research, Novartis, Emeryville, California 94608, United States., Shi PY; University of Texas Medical Branch, Galveston, Texas 77555, United States., Moser HE; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Sarko C; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States., Bradner JE; Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States., Diagana TT; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States., Tallarico JA; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2026 Feb 26; Vol. 69 (4), pp. 3868-3886. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: Discovery of EGT710, an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor.
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University of Texas Medical Branch, Galveston, Texas 77555, United States.<br /><searchLink fieldCode="AU" term="%22Moser+HE%22">Moser HE</searchLink>; Global Discovery Chemistry, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Sarko+C%22">Sarko C</searchLink>; Global Discovery Chemistry, Biomedical Research, Novartis, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Bradner+JE%22">Bradner JE</searchLink>; Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.<br /><searchLink fieldCode="AU" term="%22Diagana+TT%22">Diagana TT</searchLink>; Discovery Sciences, Biomedical Research, Novartis, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Tallarico+JA%22">Tallarico JA</searchLink>; Discovery Sciences, Biomedical Research, Novartis, Cambridge, Massachusetts 02139, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2026 Feb 26; Vol. 69 (4), pp. 3868-3886. <i>Date of Electronic Publication: </i>2026 Feb 09.
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