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Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents.

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Title: Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents.
Authors: Shaked A; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. abraham.shaked@uphs.upenn.edu., Sagar A; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Olthoff KM; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Abt PL; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Vail EA; Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Martin ND; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Abrams CS; Hematology-Oncology Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hasz RD; Gift of Life Donor Program, Philadelphia, PA, USA., Radolovic C; Gift of Life Donor Program, Philadelphia, PA, USA., Kaminski S; Gift of Life Donor Program, Philadelphia, PA, USA., Loza BL; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Markmann JF; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Low SC; eGenesis, Cambridge, MA, USA., Curtis M; eGenesis, Cambridge, MA, USA., Lanieri L; eGenesis, Cambridge, MA, USA., Swenson KG; eGenesis, Cambridge, MA, USA., Everson GT; HepQuant, LLC, Denver, CO, USA., Wagner DA; Metabolic Solutions Inc, Nashua, NH, USA., Elzawahry MA; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Fallon JI; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Abbas SH; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Fortuna D; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Furth EE; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Reddy KR; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Reese PP; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Vanderbilt Center for Transplant Science, Vanderbilt University Medical Center, Nashville, TN, USA., Friend P; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; OrganOx, Oxford, UK.
Source: Nature medicine [Nat Med] 2026 Mar; Vol. 32 (3), pp. 1034-1044. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents.
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  Data: <searchLink fieldCode="AU" term="%22Shaked+A%22">Shaked A</searchLink>; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. abraham.shaked@uphs.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Sagar+A%22">Sagar A</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Olthoff+KM%22">Olthoff KM</searchLink>; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Abt+PL%22">Abt PL</searchLink>; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Vail+EA%22">Vail EA</searchLink>; Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Martin+ND%22">Martin ND</searchLink>; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Abrams+CS%22">Abrams CS</searchLink>; Hematology-Oncology Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hasz+RD%22">Hasz RD</searchLink>; Gift of Life Donor Program, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Radolovic+C%22">Radolovic C</searchLink>; Gift of Life Donor Program, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Kaminski+S%22">Kaminski S</searchLink>; Gift of Life Donor Program, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Loza+BL%22">Loza BL</searchLink>; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Markmann+JF%22">Markmann JF</searchLink>; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Low+SC%22">Low SC</searchLink>; eGenesis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Curtis+M%22">Curtis M</searchLink>; eGenesis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Lanieri+L%22">Lanieri L</searchLink>; eGenesis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Swenson+KG%22">Swenson KG</searchLink>; eGenesis, Cambridge, MA, USA.<br /><searchLink fieldCode="AU" term="%22Everson+GT%22">Everson GT</searchLink>; HepQuant, LLC, Denver, CO, USA.<br /><searchLink fieldCode="AU" term="%22Wagner+DA%22">Wagner DA</searchLink>; Metabolic Solutions Inc, Nashua, NH, USA.<br /><searchLink fieldCode="AU" term="%22Elzawahry+MA%22">Elzawahry MA</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Fallon+JI%22">Fallon JI</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Abbas+SH%22">Abbas SH</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Fortuna+D%22">Fortuna D</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Furth+EE%22">Furth EE</searchLink>; Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Reddy+KR%22">Reddy KR</searchLink>; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Reese+PP%22">Reese PP</searchLink>; Penn Transplant Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Vanderbilt Center for Transplant Science, Vanderbilt University Medical Center, Nashville, TN, USA.<br /><searchLink fieldCode="AU" term="%22Friend+P%22">Friend P</searchLink>; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; OrganOx, Oxford, UK.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2026 Mar; Vol. 32 (3), pp. 1034-1044. <i>Date of Electronic Publication: </i>2026 Feb 09.
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