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Histone methyltransferase G9a drives vascular smooth muscle cell proliferation and intimal hyperplasia in mice.

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Title: Histone methyltransferase G9a drives vascular smooth muscle cell proliferation and intimal hyperplasia in mice.
Authors: Liu ST; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China., Liu SW; Department of Cardiovascular Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China., He SY; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China., Wang ZJ; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China., Chen MT; Emergency Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China., Shi YN; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China., Cai SD; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China., Mai YQ; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China., Liu PQ; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China., Fan MY; Emergency Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China., Liu RM; Laboratory of General Surgery, First Affiliated Hospital of Sun Yat-sen University & National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China. liuruim@mail2.sysu.edu.cn., Duan Y; Special Medical Service Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. dy0113@sina.com., Li ZM; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China. lizhm5@mail.sysu.edu.cn.
Source: Acta pharmacologica Sinica [Acta Pharmacol Sin] 2026 Jun; Vol. 47 (6), pp. 1561-1577. Date of Electronic Publication: 2026 Feb 09.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 100956087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1745-7254 (Electronic) Linking ISSN: 16714083 NLM ISO Abbreviation: Acta Pharmacol Sin Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Histone methyltransferase G9a drives vascular smooth muscle cell proliferation and intimal hyperplasia in mice.
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  Data: <searchLink fieldCode="AU" term="%22Liu+ST%22">Liu ST</searchLink>; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Liu+SW%22">Liu SW</searchLink>; Department of Cardiovascular Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.<br /><searchLink fieldCode="AU" term="%22He+SY%22">He SY</searchLink>; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Wang+ZJ%22">Wang ZJ</searchLink>; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Chen+MT%22">Chen MT</searchLink>; Emergency Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.<br /><searchLink fieldCode="AU" term="%22Shi+YN%22">Shi YN</searchLink>; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Cai+SD%22">Cai SD</searchLink>; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Mai+YQ%22">Mai YQ</searchLink>; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Liu+PQ%22">Liu PQ</searchLink>; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China.<br /><searchLink fieldCode="AU" term="%22Fan+MY%22">Fan MY</searchLink>; Emergency Department, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.<br /><searchLink fieldCode="AU" term="%22Liu+RM%22">Liu RM</searchLink>; Laboratory of General Surgery, First Affiliated Hospital of Sun Yat-sen University & National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, China. liuruim@mail2.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Duan+Y%22">Duan Y</searchLink>; Special Medical Service Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. dy0113@sina.com.<br /><searchLink fieldCode="AU" term="%22Li+ZM%22">Li ZM</searchLink>; Laboratory of Pharmacology and Toxicology, School of Pharmaceutical Sciences; National and Local United Engineering Lab of Druggability and New Drugs Evaluation; Guangdong Engineering Laboratory of Druggability and New Drug Evaluation; Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, Sun Yat-sen University, Guangzhou, 510006, China. lizhm5@mail.sysu.edu.cn.
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        Value: 10.1038/s41401-025-01714-4
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