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Identification of EEF1A1 as a therapeutic target in TNBC: Anticancer action of a novel Penicillide-derived inhibitor through ribosomal protein regulation.

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Title: Identification of EEF1A1 as a therapeutic target in TNBC: Anticancer action of a novel Penicillide-derived inhibitor through ribosomal protein regulation.
Authors: Yu J; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China., Chen RY; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China., Liu YJ; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China., Feng FJ; School of Pharmacy, Health Science Center, Ningbo University, Ningbo 315211, China., Li YJ; School of Pharmacy, Health Science Center, Ningbo University, Ningbo 315211, China., Hu YJ; School of Pharmacy, Health Science Center, Ningbo University, Ningbo 315211, China., Yang GJ; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China. Electronic address: yangguanjun@nbu.edu.cn., Chen J; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China. Electronic address: chenjiong@nbu.edu.cn., Ding LJ; School of Pharmacy, Health Science Center, Ningbo University, Ningbo 315211, China. Electronic address: dinglijian@nbu.edu.cn.
Source: Bioorganic chemistry [Bioorg Chem] 2026 May; Vol. 172, pp. 109602. Date of Electronic Publication: 2026 Feb 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of EEF1A1 as a therapeutic target in TNBC: Anticancer action of a novel Penicillide-derived inhibitor through ribosomal protein regulation.
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  Data: <searchLink fieldCode="AU" term="%22Yu+J%22">Yu J</searchLink>; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China.<br /><searchLink fieldCode="AU" term="%22Chen+RY%22">Chen RY</searchLink>; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China.<br /><searchLink fieldCode="AU" term="%22Liu+YJ%22">Liu YJ</searchLink>; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China.<br /><searchLink fieldCode="AU" term="%22Feng+FJ%22">Feng FJ</searchLink>; School of Pharmacy, Health Science Center, Ningbo University, Ningbo 315211, China.<br /><searchLink fieldCode="AU" term="%22Li+YJ%22">Li YJ</searchLink>; School of Pharmacy, Health Science Center, Ningbo University, Ningbo 315211, China.<br /><searchLink fieldCode="AU" term="%22Hu+YJ%22">Hu YJ</searchLink>; School of Pharmacy, Health Science Center, Ningbo University, Ningbo 315211, China.<br /><searchLink fieldCode="AU" term="%22Yang+GJ%22">Yang GJ</searchLink>; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China. Electronic address: yangguanjun@nbu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+J%22">Chen J</searchLink>; State Key Laboratory for Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo 315832, China. Electronic address: chenjiong@nbu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ding+LJ%22">Ding LJ</searchLink>; School of Pharmacy, Health Science Center, Ningbo University, Ningbo 315211, China. Electronic address: dinglijian@nbu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%221303703%22">Bioorganic chemistry</searchLink> [Bioorg Chem] 2026 May; Vol. 172, pp. 109602. <i>Date of Electronic Publication: </i>2026 Feb 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>1303703 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1090-2120 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200452068%22">00452068 </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.bioorg.2026.109602
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              Text: 2026 May
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