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Epigenetic and metabolic signatures in systemic lupus erythematous: The impact of excess body weight on adipose tissue DNA methylation profile.

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Title: Epigenetic and metabolic signatures in systemic lupus erythematous: The impact of excess body weight on adipose tissue DNA methylation profile.
Authors: Carvalho LM; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., da Mota JCNL; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Ribeiro AA; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Souza LL; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Sposeto RB; Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil., Pinhel MAS; Department of Molecular Biology, Sao Jose do Rio Preto Medical School, São José do Rio Preto, Brazil; Faculty of Medicine of Ribeirao Preto, Department of Health Sciences, University of São Paulo, Ribeirão Preto, Brazil., Nonino CB; Faculty of Medicine of Ribeirão Preto, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, Brazil., Costa-Fraga N; Epigenomics Unit, Cancer Epigenomics, Translational Medical Oncology Group (ONCOMET), Clinical University Hospital & Health Research Institute of Santiago de Compostela, CIBERONC, University of Santiago de Compostela, Santiago de Compostela, Spain., Crujeiras AB; Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago (CHUS, SERGAS), Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Izquierdo AG; Epigenomics Unit, Cancer Epigenomics, Translational Medical Oncology Group (ONCOMET), Clinical University Hospital & Health Research Institute of Santiago de Compostela, CIBERONC, University of Santiago de Compostela, Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Diaz-Lagares A; Epigenomics Unit, Cancer Epigenomics, Translational Medical Oncology Group (ONCOMET), Clinical University Hospital & Health Research Institute of Santiago de Compostela, CIBERONC, University of Santiago de Compostela, Santiago de Compostela, Spain., Hounkpe BW; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Borba EF; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Gualano B; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Clínicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil., Nicoletti CF; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil. Electronic address: Carolina.nicoletti.ferreira@usp.br.
Source: Genomics [Genomics] 2026 Mar; Vol. 118 (2), pp. 111217. Date of Electronic Publication: 2026 Feb 08.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 8800135 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8646 (Electronic) Linking ISSN: 08887543 NLM ISO Abbreviation: Genomics Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Epigenetic and metabolic signatures in systemic lupus erythematous: The impact of excess body weight on adipose tissue DNA methylation profile.
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  Data: <searchLink fieldCode="AU" term="%22Carvalho+LM%22">Carvalho LM</searchLink>; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22da+Mota+JCNL%22">da Mota JCNL</searchLink>; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Ribeiro+AA%22">Ribeiro AA</searchLink>; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Souza+LL%22">Souza LL</searchLink>; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Sposeto+RB%22">Sposeto RB</searchLink>; Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Pinhel+MAS%22">Pinhel MAS</searchLink>; Department of Molecular Biology, Sao Jose do Rio Preto Medical School, São José do Rio Preto, Brazil; Faculty of Medicine of Ribeirao Preto, Department of Health Sciences, University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Nonino+CB%22">Nonino CB</searchLink>; Faculty of Medicine of Ribeirão Preto, Department of Internal Medicine, University of São Paulo, Ribeirão Preto, Brazil.<br /><searchLink fieldCode="AU" term="%22Costa-Fraga+N%22">Costa-Fraga N</searchLink>; Epigenomics Unit, Cancer Epigenomics, Translational Medical Oncology Group (ONCOMET), Clinical University Hospital & Health Research Institute of Santiago de Compostela, CIBERONC, University of Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Crujeiras+AB%22">Crujeiras AB</searchLink>; Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Health Research Institute of Santiago de Compostela (IDIS), University Clinical Hospital of Santiago (CHUS, SERGAS), Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Izquierdo+AG%22">Izquierdo AG</searchLink>; Epigenomics Unit, Cancer Epigenomics, Translational Medical Oncology Group (ONCOMET), Clinical University Hospital & Health Research Institute of Santiago de Compostela, CIBERONC, University of Santiago de Compostela, Santiago de Compostela, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Diaz-Lagares+A%22">Diaz-Lagares A</searchLink>; Epigenomics Unit, Cancer Epigenomics, Translational Medical Oncology Group (ONCOMET), Clinical University Hospital & Health Research Institute of Santiago de Compostela, CIBERONC, University of Santiago de Compostela, Santiago de Compostela, Spain.<br /><searchLink fieldCode="AU" term="%22Hounkpe+BW%22">Hounkpe BW</searchLink>; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Borba+EF%22">Borba EF</searchLink>; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Gualano+B%22">Gualano B</searchLink>; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Clínicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Nicoletti+CF%22">Nicoletti CF</searchLink>; Applied Physiology and Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Brazil; Center of Lifestyle Medicine, Faculdade de Medicina FMUSP, Universidade de São Paulo, Brazil; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil. Electronic address: Carolina.nicoletti.ferreira@usp.br.
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  Data: <searchLink fieldCode="JN" term="%228800135%22">Genomics</searchLink> [Genomics] 2026 Mar; Vol. 118 (2), pp. 111217. <i>Date of Electronic Publication: </i>2026 Feb 08.
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