Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone.

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Title: Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone.
Authors: Valle-Tenney R; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Peredo N; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; VIB BioImaging Core Leuven, Center for Brain and Disease Research, KU Leuven, Leuven, Belgium., De Samblancx K; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Nefyodova E; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Cardoen R; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Dehaemers T; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Farlay D; INSERM, UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France., Chapurlat R; INSERM, UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France., Van der Schueren B; Department of Endocrinology, University Hospitals Leuven, and Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Mathieu C; Department of Endocrinology, University Hospitals Leuven, and Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Vangoitsenhoven R; Department of Endocrinology, University Hospitals Leuven, and Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Maes C; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium. christa.maes@kuleuven.be.
Source: Bone research [Bone Res] 2026 Feb 11; Vol. 14 (1), pp. 21. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2095-4700
DOI:10.1038/s41413-025-00503-3