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Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone.

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Title: Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone.
Authors: Valle-Tenney R; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Peredo N; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; VIB BioImaging Core Leuven, Center for Brain and Disease Research, KU Leuven, Leuven, Belgium., De Samblancx K; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Nefyodova E; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Cardoen R; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Dehaemers T; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium., Farlay D; INSERM, UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France., Chapurlat R; INSERM, UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France., Van der Schueren B; Department of Endocrinology, University Hospitals Leuven, and Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Mathieu C; Department of Endocrinology, University Hospitals Leuven, and Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Vangoitsenhoven R; Department of Endocrinology, University Hospitals Leuven, and Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium., Maes C; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium. christa.maes@kuleuven.be.
Source: Bone research [Bone Res] 2026 Feb 11; Vol. 14 (1), pp. 21. Date of Electronic Publication: 2026 Feb 11.
Publication Type: Journal Article
Journal Info: Publisher: West China School of Stomatology, Sichuan University Country of Publication: China NLM ID: 101608652 Publication Model: Electronic Cited Medium: Print ISSN: 2095-4700 (Print) Linking ISSN: 20954700 NLM ISO Abbreviation: Bone Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Pharmacological HIF activation protects against diet-induced obesity, glucose intolerance, and skeletal dysfunction by exerting dual beneficial effects on energy metabolism and bone.
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  Data: <searchLink fieldCode="AU" term="%22Valle-Tenney+R%22">Valle-Tenney R</searchLink>; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Peredo+N%22">Peredo N</searchLink>; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.; VIB BioImaging Core Leuven, Center for Brain and Disease Research, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Samblancx+K%22">De Samblancx K</searchLink>; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Nefyodova+E%22">Nefyodova E</searchLink>; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Cardoen+R%22">Cardoen R</searchLink>; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Dehaemers+T%22">Dehaemers T</searchLink>; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Farlay+D%22">Farlay D</searchLink>; INSERM, UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Chapurlat+R%22">Chapurlat R</searchLink>; INSERM, UMR 1033, Univ Lyon, Université Claude Bernard Lyon 1, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Van+der+Schueren+B%22">Van der Schueren B</searchLink>; Department of Endocrinology, University Hospitals Leuven, and Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Mathieu+C%22">Mathieu C</searchLink>; Department of Endocrinology, University Hospitals Leuven, and Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vangoitsenhoven+R%22">Vangoitsenhoven R</searchLink>; Department of Endocrinology, University Hospitals Leuven, and Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Maes+C%22">Maes C</searchLink>; Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Leuven, Belgium. christa.maes@kuleuven.be.
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  Data: <searchLink fieldCode="JN" term="%22101608652%22">Bone research</searchLink> [Bone Res] 2026 Feb 11; Vol. 14 (1), pp. 21. <i>Date of Electronic Publication: </i>2026 Feb 11.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22West+China+School+of+Stomatology%2C+Sichuan+University%22">West China School of Stomatology, Sichuan University </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101608652 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2095-4700 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220954700%22">20954700 </searchLink><i>NLM ISO Abbreviation: </i>Bone Res <i>Subsets: </i>MEDLINE
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