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KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.

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Title: KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.
Authors: Kamiza AB; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.; Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.; Department of Non-Communicable Disease Epidemiology (NCDE), London School of Hygiene and Tropical Medicine, London, UK.; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Chikowore T; MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chen G; Center for Research on Genomics and Global Health, National Institutes of Health, Bethesda, MD, USA., Ojewunmi O; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Machipisa T; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Hatter Institute for Cardiovascular Diseases Research in Africa (HICRA), Department of Medicine, University of Cape Town, Cape Town, South Africa., Zhou F; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Mayanja R; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; Gladstone Institutes of Data Science and Biotechnology, Gladstone Institute, San Francisco, CA, USA., Toure S; African Center of Excellence in Bioinformatics, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali., Soremekun O; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Kintu C; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.; Makerere University, Kampala, Uganda., Nakabuye M; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; Makerere University, Kampala, Uganda.; Copenhagen Health Complexity Center, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Koprulu M; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Kalungi A; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Kalyesubula R; Makerere University, Kampala, Uganda., Salako B; Nigerian Institute of Medical Research, Lagos, Nigeria., Nashiru O; Center for Genomics Research and Innovation, National Biotechnology Development Agency, Abuja, Nigeria., Corpas M; College of Liberal Arts and Sciences, University of Westminster, London, UK.; Cambridge Precision Medicine Limited, ideaSpace, University of Cambridge Biomedical Innovation Hub, Cambridge, UK., Robinson-Cohen C; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Franceschini N; The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Pattaro C; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Köttgen A; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany., Nitsch D; Department of Non-Communicable Disease Epidemiology (NCDE), London School of Hygiene and Tropical Medicine, London, UK., Langenberg C; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.; Berlin Institute of Health at Charité, Berlin, Germany., Tcheandjieu C; Gladstone Institutes of Data Science and Biotechnology, Gladstone Institute, San Francisco, USA.; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA., Nyirenda M; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; Department of Non-Communicable Disease Epidemiology (NCDE), London School of Hygiene and Tropical Medicine, London, UK., Morris AP; Centre for Genetics and Genomics Versus Arthritis, University of Manchester, Manchester, UK., Asimit J; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Medicine and Health, Technical University of Munich (TUM), TUM University Hospital, Munich, Germany., Rotimi C; Center for Research on Genomics and Global Health, National Institutes of Health, Bethesda, MD, USA., Ramsay M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Adeyemo A; Center for Research on Genomics and Global Health, National Institutes of Health, Bethesda, MD, USA., Fabian J; Medical Research Council/Wits University Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Wits Donald Gordon Medical Research Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Crampin AC; Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.; School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi.; School of Health and Wellbeing, University of Glasgow, Glasgow, UK.; Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK., Brandenburg JT; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Strengthening Oncology Services Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Fatumo S; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda. s.fatumo@qmul.ac.uk.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK. s.fatumo@qmul.ac.uk.; Department of Non-Communicable Disease Epidemiology (NCDE), London School of Hygiene and Tropical Medicine, London, UK. s.fatumo@qmul.ac.uk.
Source: Nature communications [Nat Commun] 2026 Feb 10; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 10.
Publication Type: Journal Article; Meta-Analysis
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.
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  Data: <searchLink fieldCode="AU" term="%22Kamiza+AB%22">Kamiza AB</searchLink>; Medical Research Council, Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine (MRC/UVRI &LSHTM), Entebbe, Uganda.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.; Malawi Epidemiology and Intervention Research Unit, Lilongwe, Malawi.; Department of Non-Communicable Disease Epidemiology (NCDE), London School of Hygiene and Tropical Medicine, London, UK.; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.<br /><searchLink fieldCode="AU" term="%22Chikowore+T%22">Chikowore T</searchLink>; MRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.; 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